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公开(公告)号：US20130035755A1
公开(公告)日：2013-02-07
申请号：US13589907
申请日：2012-08-20
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.
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公开(公告)号：US07803183B2
公开(公告)日：2010-09-28
申请号：US10832106
申请日：2004-04-26
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： A medical device with a coating for capturing target cells in vivo is provided. In particular, the medical device is coated with at least one layer of matrix and a layer of antibodies, antibody fragments or combinations thereof, which bind with specificity to mature or progenitor endothelial cells at various developmental stages to form an endothelial cell layer on the surface of the device. The coated medical device can be, for example, a stent or a synthetic graft and is useful in therapy of diseases such as restenosis, atherosclerosis, and thromboembolic complications.
摘要翻译： 提供了一种具有用于在体内捕获靶细胞的涂层的医疗装置。 特别地，医疗装置涂覆有至少一层基质和一层抗体，抗体片段或其组合，其在各种发育阶段与成熟或祖细胞内皮细胞特异性结合，以在表面上形成内皮细胞层 的设备。 涂覆的医疗装置可以是例如支架或合成移植物，并且可用于治疗诸如再狭窄，动脉粥样硬化和血栓栓塞并发症的疾病。
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公开(公告)号：US07037332B2
公开(公告)日：2006-05-02
申请号：US09808867
申请日：2001-03-15
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： A medical device coated with one or more antibodies and one or more layers of a matrix is disclosed. The antibodies or fragments thereof react with an endothelial cell surface antigen. Also disclosed are compositions and methods for producing the medical device. The matrix coating the medical device may be composed of a synthetic material, such as a fullerene, or a naturally occurring material. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote the adherence of cells captured in vivo on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies. By facilitating adherence of cells to the surface of the medical device, the disclosed methods and compositions will decrease the incidence of restenosis as well as other thromboembolic complications resulting from implantation of medical devices.
摘要翻译： 公开了涂覆有一种或多种抗体和一层或多层基质的医疗装置。 抗体或其片段与内皮细胞表面抗原反应。 还公开了用于生产医疗装置的组合物和方法。 涂覆医疗装置的基质可以由合成材料，例如富勒烯或天然存在的材料组成。 富勒烯的范围为约C60至约C100。 医疗装置可以是支架或合成移植物。 该抗体促进在体内在体外捕获的细胞对医疗装置的粘附。 可以将抗体与基质混合或通过连接体分子共价连接到基质上。 在粘附到医疗装置之后，细胞在医疗装置上分化和增殖。 抗体可以是不同类型的单克隆抗体。 通过促进细胞粘附到医疗装置的表面，所公开的方法和组合物将降低再狭窄的发生率以及由植入医疗装置引起的其它血栓栓塞并发症。
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公开(公告)号：US20050043787A1
公开(公告)日：2005-02-24
申请号：US10832106
申请日：2004-04-26
IPC分类号： A61B17/00 , A61F2/84 , A61K39/395 , A61L27/00 , A61L27/08 , A61L27/30 , A61L27/44 , A61L27/54 , A61L29/10 , A61L29/12 , A61L29/16 , A61L31/00 , A61L31/08 , A61L31/12 , A61L31/16 , A61P9/10 , C12N5/074 , A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： This invention provides compositions and methods for producing a medical device coated with a matrix and an antibody which reacts with an endothelial cell antigen. The matrix coating the medical device may be composed of synthetic material, such as polyurethane, poly-L-lactic acid, cellulose ester or polyethylene glycol. In another embodiment, the matrix is composed of naturally occurring materials, such as collagen, fibrin, elastin, amorphous carbon. In a third embodiment, the matrix may be composed of fullerenes. The fullerenes range from about C60 to about C100. The medical device may be a stent or a synthetic graft. The antibodies promote adherence of endothelial cells on the medical device. The antibodies may be mixed with the matrix or covalently tethered through a linker molecule to the matrix. Following adherence to the medical device, the endothelial cells differentiate and proliferate on the medical device. The antibodies may be different types of monoclonal antibodies. Methods of preparing such composition and methods of treating a mammal with atherosclerosis or other types of vessel obstruction are disclosed. By facilitating adherence of endothelial cells to the surface of the medical device, the methods and compositions of this invention will decrease the incidence of restenosis as well as other thromboembolic complications resulting from implantation of medical devices.
摘要翻译： 本发明提供了用于制备涂覆有基质和与内皮细胞抗原反应的抗体的医疗器械的组合物和方法。 涂覆医疗装置的基质可以由合成材料如聚氨酯，聚-L-乳酸，纤维素酯或聚乙二醇组成。 在另一个实施方案中，基质由天然存在的材料组成，例如胶原，纤维蛋白，弹性蛋白，无定形碳。 在第三实施方案中，基质可以由富勒烯构成。 富勒烯的范围为约C60至约C100。 医疗装置可以是支架或合成移植物。 抗体促进内皮细胞在医疗装置上的粘附。 可以将抗体与基质混合或通过连接体分子共价连接到基质上。 在粘附于医疗装置之后，内皮细胞在医疗装置上分化和增殖。 抗体可以是不同类型的单克隆抗体。 公开了制备这种组合物的方法和治疗动脉粥样硬化或其它类型的血管阻塞的哺乳动物的方法。 通过促进内皮细胞粘附到医疗装置的表面，本发明的方法和组合物将降低再狭窄的发生率以及由植入医疗装置引起的其它血栓栓塞并发症。
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