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    Cytotoxic agents containing novel potent taxanes and their therapeutic use
    1.
    发明申请
    Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
    含有新型有效紫杉烷类及其治疗用途的细胞毒素

    公开(公告)号：US20050085513A1

    公开(公告)日：2005-04-21

    申请号：US10963711

    申请日：2004-10-14

    申请人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

    发明人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

    IPC分类号： A61K31/337 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D305/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  A61K31/4025 ,  A61K31/4433 ,  C07D45/02

    CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

    摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a link, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

    摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒性量的一种或多种通过连接体与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

    Cytotoxic agents containing novel potent taxanes and their therapeutic use
    4.
    发明申请
    Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
    含有新型有效紫杉烷类及其治疗用途的细胞毒素

    公开(公告)号：US20050026997A1

    公开(公告)日：2005-02-03

    申请号：US10926192

    申请日：2004-08-26

    申请人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

    发明人： Erkan Baloglu ,  Michael Miller ,  Ravi Chari

    IPC分类号： A61K31/337 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D305/14 ,  C07D407/12 ,  C07D407/14 ,  C07D409/12 ,  C07

    CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

    摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

    摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒量的一种或多种通过连接基团与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 包括。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

    Cytotoxic agents containing novel potent taxanes and their therapeutic use
    5.
    发明授权
    Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
    含有新型有效紫杉烷类及其治疗用途的细胞毒素

    公开(公告)号：US07414073B2

    公开(公告)日：2008-08-19

    申请号：US10963711

    申请日：2004-10-14

    申请人： Erkan Baloglu ,  Michael Miller ,  Ravi V. J. Chari

    发明人： Erkan Baloglu ,  Michael Miller ,  Ravi V. J. Chari

    IPC分类号： A61K31/335 ,  A61K31/38 ,  C07D305/00 ,  C07D307/00 ,  C07D409/00

    CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

    摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a link, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

    摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒性量的一种或多种通过连接体与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

    Cytotoxic agents containing novel potent taxanes and their therapeutic use
    6.
    发明授权
    Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
    含有新型有效紫杉烷类及其治疗用途的细胞毒素

    公开(公告)号：US07390898B2

    公开(公告)日：2008-06-24

    申请号：US10369563

    申请日：2003-02-21

    申请人： Erkan Baloglu ,  Michael Miller ,  Ravi V. J. Chari

    发明人： Erkan Baloglu ,  Michael Miller ,  Ravi V. J. Chari

    IPC分类号： C07D413/00 ,  C07D305/00

    CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

    摘要： Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

    摘要翻译： 包括在本发明范围内的有效的紫杉烷含有连接基团。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选择的细胞群体中诱导细胞死亡的治疗组合物，其包含：（A）通过连接基团与细胞粘附剂共价结合的一种或多种紫杉烷的细胞毒性量，和（B）药学上可接受的载体，稀释剂或赋形剂 包括。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。

    Cytotoxic agents containing novel potent taxanes and their therapeutic use
    7.
    发明授权
    Cytotoxic agents containing novel potent taxanes and their therapeutic use 失效
    含有新型有效紫杉烷类及其治疗用途的细胞毒素

    公开(公告)号：US07495114B2

    公开(公告)日：2009-02-24

    申请号：US10926192

    申请日：2004-08-26

    申请人： Erkan Baloglu ,  Michael Miller ,  Ravi V. J. Chari

    发明人： Erkan Baloglu ,  Michael Miller ,  Ravi V. J. Chari

    IPC分类号： C07D305/00

    CPC分类号： C07D407/12 ,  A61K31/337 ,  C07D305/14 ,  C07D407/14 ,  C07D409/12 ,  Y02A50/423 ,  Y02A50/491

    摘要： Included within the scope of the present invention are potent taxanes and taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in selected cell populations comprising: (A) a cytotoxic amount of one or more taxanes covalently bonded to a cell binding agent through a linking group, and (B) a pharmaceutically acceptable carrier, diluent or excipient is also included. A method for inducing cell death in selected cell populations comprising contacting target cells or tissue containing target cells with an effective amount of a cytotoxic agent comprising one or more taxanes linked to a cell binding agent is included as well.

    摘要翻译： 包括在本发明范围内的有效的紫杉烷类和含有连接基团的紫杉烷类。 还包括细胞毒性剂，其包含与细胞结合剂连接的一种或多种紫杉烷类。 一种用于在所选细胞群体中诱导细胞死亡的治疗组合物，包括：（A）细胞毒量的一种或多种通过连接基团与细胞结合剂共价结合的紫杉烷，和（B）药学上可接受的载体，稀释剂或赋形剂 包括。 还包括诱导选择的细胞群体中的细胞死亡的方法，包括使靶细胞或含有靶细胞的组织与有效量的包含与细胞结合剂连接的一种或多种紫杉烷的细胞毒性试剂接触。