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公开(公告)号：US20060234909A1
公开(公告)日：2006-10-19
申请号：US11376695
申请日：2006-03-14
申请人： Michael Newman , Angelo Castellino , Joel Desharnais , Zijian Guo , Qing Li , Carlo Ballatore , Chengzao Sun
发明人： Michael Newman , Angelo Castellino , Joel Desharnais , Zijian Guo , Qing Li , Carlo Ballatore , Chengzao Sun
CPC分类号： C07K7/08 , A61K31/337 , A61K31/475 , A61K31/704 , A61K38/00 , A61K47/54 , A61K47/64 , A61K47/65 , C07K7/06
摘要： In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.
摘要翻译： 在一个实施方案中，本文提供了用于提高药物效率的组合物和方法。 在某些实施方案中，组合物包含具有下式的共轭物：<？in-line-formula description =“In-line Formulas”end =“lead”？> DLS <？in-line-formula description =“In-line Formulas” end =“tail”？>其中D是药物部分; 可能存在或不存在的L是非释放连接体部分; 并且S是蛋白质或脂质激酶的底物，其在靶系统中过表达，过度活化或表现出不期望的活性。
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公开(公告)号：US20050187147A1
公开(公告)日：2005-08-25
申请号：US10948707
申请日：2004-09-22
申请人： Michael Newman , Angelo Castellino , Joel Desharnais , Zijian Guo , Qing Li , Carlo Ballatore , Chengzao Sun
发明人： Michael Newman , Angelo Castellino , Joel Desharnais , Zijian Guo , Qing Li , Carlo Ballatore , Chengzao Sun
IPC分类号： A61K31/337 , A61K31/475 , A61K31/704 , A61K38/00 , A61K47/48 , A61K49/04 , A61P29/00 , A61P35/00 , C07K7/06 , C07K7/08 , A61K38/14 , A61K38/08
CPC分类号： C07K7/08 , A61K31/337 , A61K31/475 , A61K31/704 , A61K38/00 , A61K47/54 , A61K47/64 , A61K47/65 , C07K7/06
摘要： In one embodiment, provided herein are compositions and methods for increasing drug efficiency. In certain embodiments, the compositions contain conjugates having the formula: D-L-S wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; and S is a substrate for a protein or lipid kinase that is overexpressed, overactive or exhibits undesired activity in a target system.
摘要翻译： 在一个实施方案中，本文提供了用于提高药物效率的组合物和方法。 在某些实施方案中，组合物包含具有下式的共轭物：<？in-line-formula description =“In-line Formulas”end =“lead”？> DLS <？in-line-formula description =“In-line Formulas” end =“tail”？>其中D是药物部分; 可能存在或不存在的L是非释放连接体部分; 并且S是蛋白质或脂质激酶的底物，其在靶系统中过表达，过度活化或表现出不期望的活性。
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3.发明申请Small molecule compositions and methods for increasing drug efficiency using compositions thereof 审中-公开小分子组合物和使用其组合物提高药物效率的方法公开(公告)号：US20050148534A1
公开(公告)日：2005-07-07
申请号：US10948364
申请日：2004-09-22
申请人： Angelo Castellino , Carlo Ballatore , Simon Aspland , Joel Desharnais , Michael Newman , Chengzao Sun , Peter Wirsching
发明人： Angelo Castellino , Carlo Ballatore , Simon Aspland , Joel Desharnais , Michael Newman , Chengzao Sun , Peter Wirsching
IPC分类号： A61K31/513 , A61K31/522 , A61K31/7072 , A61K31/7076 , A61K47/48 , A61K48/00
CPC分类号： A61K31/7076 , A61K31/513 , A61K31/522 , A61K31/7072 , A61K47/55
摘要： In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S (1) or formula 2: D-L-S′ (2) wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S′ is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.
摘要翻译： 在某些实施方案中，本文提供了用于提高药物效率的组合物和方法。 在某些实施方案中，提供的缀合物用于治疗各种疾病的组合物和方法，并具有式1：<？in-line-formula description =“In-line Formulas”end =“lead”？> DLS（1） 或“公式2”：<？in-line-formula description =“In-line formula”end =“lead”？> DLS' （2）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中D是药物部分; 可能存在或不存在的L是非释放连接体部分; S是除己糖激酶，蛋白激酶或脂质激酶以外的激酶的底物; 和S'是除己糖激酶，蛋白激酶或脂质激酶之外的磷酸转移酶的底物。
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公开(公告)号：US08898065B2
公开(公告)日：2014-11-25
申请号：US13345265
申请日：2012-01-06
IPC分类号： G10L15/00
CPC分类号： G10L15/30 , G10L15/22 , G10L15/32 , G10L17/005
摘要： Techniques for combining the results of multiple recognizers in a distributed speech recognition architecture. Speech data input to a client device is encoded and processed both locally and remotely by different recognizers configured to be proficient at different speech recognition tasks. The client/server architecture is configurable to enable network providers to specify a policy directed to a trade-off between reducing recognition latency perceived by a user and usage of network resources. The results of the local and remote speech recognition engines are combined based, at least in part, on logic stored by one or more components of the client/server architecture.
摘要翻译： 在分布式语音识别架构中组合多个识别器的结果的技术。 输入到客户端设备的语音数据由本地和远程地由不同的识别器进行编码和处理，该识别器被配置为精通不同语音识别任务。 客户端/服务器体系结构是可配置的，以使网络提供商能够指定针对在减少用户感知的识别延迟和使用网络资源之间进行权衡的策略。 本地和远程语音识别引擎的结果至少部分地基于由客户端/服务器架构的一个或多个组件存储的逻辑。
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公开(公告)号：US08333087B2
公开(公告)日：2012-12-18
申请号：US12184386
申请日：2008-08-01
CPC分类号： F25D13/067 , A21B1/26 , A21B1/48
摘要： A heat transfer system for refrigeration and/or heating of products includes a housing having an internal chamber, a baffle, a spiral pathway around the baffle, a gas flow pathway and a blower to circulate gas along the gas flow pathway. The baffle separates the chamber into upper and lower portions. The spiral pathway includes an upper spiral pathway within the upper portion, and a lower spiral pathway within the lower portion. The gas flow pathway includes an upper gas flow pathway across the upper spiral pathway and a lower gas flow pathway across the lower spiral pathway in which gas flow in the upper and lower gas flow pathways defines a circulation loop. The width of the upper gas flow pathway and upper spiral pathway are similar, and the width of the lower gas flow pathway and lower spiral pathway are similar.
摘要翻译： 用于制冷和/或加热产品的传热系统包括具有内室，挡板，围绕挡板的螺旋路径的壳体，气流通道和鼓风机，以沿气体流路循环气体。 挡板将腔室分成上部和下部。 螺旋通道包括在上部内的上螺旋通路，下部包括下螺旋通路。 气流通道包括穿过上螺旋通路的上气流通道和穿过下螺旋路径的下气流通道，其中上，下气流通道中的气流限定循环回路。 上部气体流路和上部螺旋路径的宽度相似，下部气体流路和下部螺旋路径的宽度相似。
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公开(公告)号：US20120179457A1
公开(公告)日：2012-07-12
申请号：US13345219
申请日：2012-01-06
CPC分类号： G10L15/30 , G10L15/22 , G10L15/32 , G10L17/005
摘要： Techniques for combining the results of multiple recognizers in a distributed speech recognition architecture. Speech data input to a client device is encoded and processed both locally and remotely by different recognizers configured to be proficient at different speech recognition tasks. The client/server architecture is configurable to enable network providers to specify a policy directed to a trade-off between reducing recognition latency perceived by a user and usage of network resources. The results of the local and remote speech recognition engines are combined based, at least in part, on logic stored by one or more components of the client/server architecture.
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公开(公告)号：US20110094498A1
公开(公告)日：2011-04-28
申请号：US12911135
申请日：2010-10-25
申请人： Michael Newman , Glen Newman
发明人： Michael Newman , Glen Newman
CPC分类号： F24S50/00 , F24D11/003 , F24D2200/14 , F24S40/60 , Y02B10/20 , Y02E10/40
摘要： A solar water heater includes a drainback unit with a drainback reservoir and an anti-airlock conduit for assuring that working fluid in the solar collectors is consistently drained from the solar collectors into a drainback reservoir once circulation the working fluid in the solar collectors has stopped. The drainback unit also provides rapid startup by positioning the heat exchanger outside of the drainback reservoir and by positioning the inlet and outlet of drainback reservoir in close proximity to each other.
摘要翻译： 太阳能热水器包括具有排水储存器和防气锁导管的排水装置，用于确保太阳能收集器中的工作流体一旦从太阳能收集器排出到排水储存器中，一旦太阳能收集器中的工作流体循环停止。 排水装置还通过将热交换器定位在排水储存器的外部并且通过将排水储存器的入口和出口彼此靠近地定位来提供快速启动。
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8.发明申请Method of forming through-silicon vias with stress buffer collars and resulting devices 审中-公开用应力缓冲圈和结果装置形成通硅通孔的方法公开(公告)号：US20080251932A1
公开(公告)日：2008-10-16
申请号：US12157806
申请日：2008-06-12
IPC分类号： H01L23/48
CPC分类号： H01L21/76898 , H01L2224/13 , H01L2924/1461 , H01L2924/00
摘要： A method of forming a via having a stress buffer collar, wherein the stress buffer collar can absorb stress resulting from a mismatch in the coefficients of thermal expansion of the surrounding materials. Other embodiments are described and claimed.
摘要翻译： 一种形成具有应力缓冲套环的通孔的方法，其中所述应力缓冲环可以吸收由周围材料的热膨胀系数不匹配引起的应力。 描述和要求保护其他实施例。
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公开(公告)号：US20070203215A1
公开(公告)日：2007-08-30
申请号：US11627289
申请日：2007-01-25
申请人： Michael Newman , William Dixon
发明人： Michael Newman , William Dixon
IPC分类号： A61K31/417
CPC分类号： C07D233/64 , A61K31/415 , A61K31/417 , A61K45/06 , A61K2300/00
摘要： Improved methods are provided for therapeutic and/or preventative treatment to a mammal in which the mammal is protected against the toxicity of active pharmaceutical agents that (i) bind to or are substrates for P-gp, (ii) are taxane analogues, and/or (iii) are inhibitors of tubulin disassembly. Additionally provided are compositions and methods useful for treating cell proliferative disorders. Further provided are methods of increasing the bioavailability of therapeutic and/or preventative treatments in a mammal. Particular embodiments are directed to increasing such bioavailability across the blood-brain barrier.
摘要翻译： 提供了用于治疗和/或预防性治疗哺乳动物的改进方法，其中所述哺乳动物被保护免受活性药剂的毒性，所述活性药剂（i）与P-gp结合或是底物，（ii）是紫杉烷类似物和/ 或（iii）是微管蛋白分解的抑制剂。 另外提供了可用于治疗细胞增殖性疾病的组合物和方法。 还提供了增加哺乳动物中治疗和/或预防性治疗的生物利用度的方法。 具体实施方案涉及通过血脑屏障增加这种生物利用度。
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公开(公告)号：US20050226817A1
公开(公告)日：2005-10-13
申请号：US11147025
申请日：2005-06-07
申请人： Michael Newman , Stephen McCormick
发明人： Michael Newman , Stephen McCormick
CPC分类号： A01N25/18
摘要： An apparatus and method of microbiocidal gas generation includes generating a microbiocidal agent, such as lactic acid, without the need for a carrier gas. A liquid microbiocidal agent is introduced into a heat exchanger where it is heated to generate a gaseous miocrobiocidal agent without a carrier gas for use with food products, while eliminating the costs, additional equipment and additional steps associated with the use of a carrier gas in the generation of microbiocidal agents.
摘要翻译： 微生物气体发生的装置和方法包括生成杀微生物剂如乳酸，而不需要载气。 将液体杀微生物剂引入热交换器中，在其中将其加热以产生气体杀微生物剂，而没有用于食品的载体气体，同时消除与使用载体气体相关的成本，附加设备和附加步骤 生成杀微生物剂。
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