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公开(公告)号：US08734352B2
公开(公告)日：2014-05-27
申请号：US13383471
申请日：2010-06-23
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B5/0048 , A61B8/485 , G01S7/52042
摘要： Shear wave dispersion ultrasound vibrometry (SDUV) is implemented in some embodiments to form, from a single tracking pulse, in-parallel-directed receive lines (411-426) for making measurements of a monochromatic shear wave. In some embodiments, sampling is performed, over spatial locations by means of passes over the locations, in an interlaced pattern (600) for making measurements of the wave. In some embodiments, measurements are made of the wave and to the measurements are applied a bank of filters (S724) that are tuned to respective candidate wave speeds, all without the need to determine a difference between wave phases at different spatial locations (451-454).
摘要翻译： 在一些实施例中实施剪切波分散超声波振动测量（SDUV），以从单个跟踪脉冲形成用于进行单色剪切波的测量的并行导向的接收线（411-426）。 在一些实施例中，通过在位置上的通过在隔行扫描图案（600）中通过空间位置进行采样，以进行波的测量。 在一些实施例中，对波进行测量，并且将测量值应用于被调谐到各个候选波速的滤波器组（S724），全部不需要确定不同空间位置处的波相位之间的差（451- 454）。
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公开(公告)号：US20120116220A1
公开(公告)日：2012-05-10
申请号：US13383471
申请日：2010-06-23
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B5/0048 , A61B8/485 , G01S7/52042
摘要： Shear wave dispersion ultrasound vibrometry (SDUV) is implemented in some embodiments to form, from a single tracking pulse, in-parallel-directed receive lines (411-426) for making measurements of a monochromatic shear wave. In some embodiments, sampling is performed, over spatial locations by means of passes over the locations, in an interlaced pattern (600) for making measurements of the wave. In some embodiments, measurements are made of the wave and to the measurements are applied a bank of filters (S724) that are tuned to respective candidate wave speeds, all without the need to determine a difference between wave phases at different spatial locations (451-454).
摘要翻译： 在一些实施例中实施剪切波分散超声波振动测量（SDUV），以从单个跟踪脉冲形成用于进行单色剪切波的测量的并行导向的接收线（411-426）。 在一些实施例中，通过在位置上的通过在隔行扫描图案（600）中通过空间位置进行采样，以进行波的测量。 在一些实施例中，对波进行测量，并且将测量值应用于被调谐到各个候选波速的滤波器组（S724），全部不需要确定不同空间位置处的波相位之间的差（451- 454）。
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公开(公告)号：US20120123262A1
公开(公告)日：2012-05-17
申请号：US13379741
申请日：2010-06-30
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B5/0048 , A61B5/0051 , A61B8/085 , A61B8/485 , A61B8/5223 , G01S7/52022
摘要： Shear Wave Dispersion Vibrometry (SDUV) is performed such that, after a single instance of their push pulse (218), a plurality of tracking pulses (222) are issued to sample, more than once, each of a plurality of locations (120, 148) on an associated monochromatic shear wave (116) in sampling that at least one of scans the plural locations in separate passes and, with a pulse of the plural tracking pulses, samples multiple ones of the plural locations concurrently. In a supplementary aspect, phase difference, for a given moment, is determined by taking into account intersample delay (156), if the determination relies on samples that are taken at different times.
摘要翻译： 执行剪切波分散振动波谱（SDUV），使得在其单次推送脉冲（218）之后，发出多个跟踪脉冲（222）以多次采样多个位置（120,120）中的每一个， 148）在相关联的单色剪切波（116）上进行采样，以便在单独的通过中的多个位置的扫描中的至少一个并且多个跟踪脉冲中的脉冲同时对多个位置中的多个位置进行采样。 在补充方面，如果确定依赖于在不同时间拍摄的样本，则通过考虑采样间延迟（156）来确定给定时刻的相位差。
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公开(公告)号：US09125547B2
公开(公告)日：2015-09-08
申请号：US13379741
申请日：2010-06-23
CPC分类号： A61B8/00 , A61B5/0048 , A61B5/0051 , A61B8/085 , A61B8/485 , A61B8/5223 , G01S7/52022
摘要： Shear Wave Dispersion Vibrometry (SDUV) is performed such that, after a single instance of their push pulse (218), a plurality of tracking pulses (222) are issued to sample, more than once, each of a plurality of locations (120, 148) on an associated monochromatic shear wave (116) in sampling that at least one of scans the plural locations in separate passes and, with a pulse of the plural tracking pulses, samples multiple ones of the plural locations concurrently. In a supplementary aspect, phase difference, for a given moment, is determined by taking into account intersample delay (156), if the determination relies on samples that are taken at different times.
摘要翻译： 执行剪切波分散振动波谱（SDUV），使得在其单次推送脉冲（218）之后，发出多个跟踪脉冲（222）以多次采样多个位置（120,120）中的每一个， 148）在相关联的单色剪切波（116）上进行采样，以便在单独的通过中的多个位置的扫描中的至少一个并且多个跟踪脉冲中的脉冲同时对多个位置中的多个位置进行采样。 在补充方面，如果确定依赖于在不同时间拍摄的样本，则通过考虑采样间延迟（156）来确定给定时刻的相位差。
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公开(公告)号：US20130131511A1
公开(公告)日：2013-05-23
申请号：US13511307
申请日：2010-11-15
申请人： Roy Beck Peterson , Yan Shi , Hua Xie , Jean-Luc Robert , Vijay Shamdasani , Robert Randall Entrekin , Anna Teresa Fernandez
发明人： Roy Beck Peterson , Yan Shi , Hua Xie , Jean-Luc Robert , Vijay Shamdasani , Robert Randall Entrekin , Anna Teresa Fernandez
CPC分类号： A61B8/485 , A61B5/0048 , A61B8/08 , A61B8/085 , A61B8/14 , A61B8/463 , A61B8/5223 , G01S7/52022 , G01S7/52042 , G01S7/52071 , G01S7/52095 , G01S15/8984
摘要： An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.
摘要翻译： 超声波诊断成像系统通过传递推动脉冲来产生剪切波速度的图像以产生剪切波。 多个跟踪线被发送，并且由聚焦波束形成器接收的与推送脉冲位置相邻的回波。 跟踪线以时间交织的方式进行采样。 处理沿着每个跟踪线获取的回波数据，以确定由沿着跟踪线的点处的剪切波引起的峰组织位移的时间，以及相邻跟踪线的峰值时间，以计算局部剪切波速度。 所得到的剪切波速度值的映射是彩色编码的，并显示在感兴趣区域的解剖图像上。
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公开(公告)号：US10390797B2
公开(公告)日：2019-08-27
申请号：US13995522
申请日：2011-12-19
申请人： Yan Shi , Hua Xie , Roy Peterson , Jean-Luc Robert , Vijay Shamdasani
发明人： Yan Shi , Hua Xie , Roy Peterson , Jean-Luc Robert , Vijay Shamdasani
摘要： A device and a method for computing a weighted-average-based position of a shear wave in a temporal domain based on a sampling of shear wave displacements along a propagation path of the shear wave. The weighted-average-based position is, for example, by displacement observed at a plurality of times that correspond to sampling, and represents a time of arrival of the shear wave at a location being sampled along the propagation path. Further, times of arrival of the shear wave at respective locations along the propagation path are functionally related to known inter-location distances to derive shear-wave group velocity. The derived shear-wave group velocity serves as an input into algorithms for estimating a shear elasticity of a medium, such as a body tissue, for purposes of a clinical diagnosis and therapy assessment.
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公开(公告)号：US10368843B2
公开(公告)日：2019-08-06
申请号：US13511307
申请日：2010-11-15
申请人： Roy Beck Peterson , Yan Shi , Hua Xie , Jean-Luc Robert , Vijay Shamdasani , Robert Randall Entrekin , Anna Teresa Ferandez
发明人： Roy Beck Peterson , Yan Shi , Hua Xie , Jean-Luc Robert , Vijay Shamdasani , Robert Randall Entrekin , Anna Teresa Ferandez
摘要： An ultrasonic diagnostic imaging system produces an image of shear wave velocities by transmitting push pulses to generate shear waves. A plurality of tracking lines are transmitted and echoes received by a focusing beamformer adjacent to the location of the push pulses. The tracking lines are sampled in a time-interleaved manner. The echo data acquired along each tracking line is processed to determine the time of peak tissue displacement caused by the shear waves at points along the tracking line, and the times of peaks at adjacent tracking lines compared to compute a local shear wave velocity. The resultant map of shear wave velocity values is color-coded and displayed over an anatomical image of the region of interest.
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公开(公告)号：US20130317362A1
公开(公告)日：2013-11-28
申请号：US13995522
申请日：2011-12-19
申请人： Yan Shi , Hua Xie , Roy Peterson , Jean-Luc Robert , Vijay Shamdasani
发明人： Yan Shi , Hua Xie , Roy Peterson , Jean-Luc Robert , Vijay Shamdasani
CPC分类号： A61B8/5207 , A61B5/0051 , A61B5/055 , A61B5/4244 , A61B5/7235 , A61B8/4483 , A61B8/485 , A61B2562/0204
摘要： The weighted-average-based position (244) in the temporal domain is computed based on the sampling of shear wave displacement (226) along the propagation path. The weighting is, for example, by displacement observed at times (230) corresponding to sampling and represents the time of arrival of the shear wave at the shear-wave propagation path location being sampled. In some embodiments, the computed shear-wave times of arrival at respective locations are functionally related to known inter-location distances (250) to derive shear-wave group velocity. The derived velocity can serve as input into known algorithms for estimating shear elasticity of the medium, such as body tissue, for purposes of clinical diagnosis and therapy assessment.
摘要翻译： 基于沿着传播路径的剪切波位移（226）的采样来计算时域中的基于加权平均的位置（244）。 加权是例如通过对应于采样的时间（230）观察到的位移，并且表示剪切波在被采样的剪切波传播路径位置处的到达时间。 在一些实施例中，到达相应位置的计算的剪切波时间在功能上与已知位置间距（250）有关，以导出剪切波群速度。 为了临床诊断和治疗评估的目的，导出的速度可以用作用于估计介质（例如身体组织）的剪切弹性的已知算法的输入。
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公开(公告)号：US10448924B2
公开(公告)日：2019-10-22
申请号：US13992281
申请日：2011-12-02
摘要： An ultrasonic diagnostic imaging system for shear wave measurement transmits push pulses in the form of a sheet of energy. The sheet of energy produces a shear wavefront which is a plane wave, which does not suffer from the 1/R radial dissipation of push pulse force as does a conventional push pulse generated along a single push pulse vector. The sheet of energy can be planar, curved, or in some other two or three dimensional shape. A curved sheet of energy can produce a shear wave source which focuses into a thin line, which increases the resolution and sensitivity of the measuring techniques used to detect the shear wave effect.
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公开(公告)号：US20110177980A1
公开(公告)日：2011-07-21
申请号：US11759048
申请日：2007-06-06
申请人： Bingcheng Lin , Bowel Li , Hua Xie , Jianhua Qin , Yisheng Zhu , Zhende Huang
发明人： Bingcheng Lin , Bowel Li , Hua Xie , Jianhua Qin , Yisheng Zhu , Zhende Huang
IPC分类号： C40B60/08
CPC分类号： B82Y10/00 , G06N99/007
摘要： The present invention relates to computer science, molecular biology and microfluidics technique which provides a DNA molecular computer based on microfluidic chip. The objective is to provide a DNA molecular computer which uses the microfluidic chip as a operation platform, mainly including: using DNA molecules as operation media, using the microfluidic chip as the operation platform of a DNA molecular operator; using DNA molecules as storage media, using the microfluidic chip as the operation platform of a DNA molecular storage; using a electronic computer and a detector as the kernel of a controller; said microfluidic chip includes a DNA molecular computation region and a DNA molecular storage region. The microfluidic chip consists of digestion, ligation, PCR amplification and chip electrophoresis unit connected by microchannels in turn, and carries out the liquid control through micropumps and microvalves.
摘要翻译： 本发明涉及计算机科学，分子生物学和微流体技术，其提供了基于微流控芯片的DNA分子计算机。 目的是提供一种使用微流控芯片作为操作平台的DNA分子计算机，主要包括：使用DNA分子作为操作介质，使用微流控芯片作为DNA分子操作者的操作平台; 使用DNA分子作为存储介质，使用微流控芯片作为DNA分子存储的操作平台; 使用电子计算机和检测器作为控制器的内核; 所述微流体芯片包括DNA分子计算区域和DNA分子存储区域。 微流控芯片由消化，连接，PCR扩增和芯片电泳单元依次由微通道连接，并通过微泵和微型阀进行液体控制。
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