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    Dual-filled twin bag, a package and a method for forming a package for administering a solution
    1.
    发明授权
    Dual-filled twin bag, a package and a method for forming a package for administering a solution 有权
    双填充双袋，包装和用于形成用于施用溶液的包装的方法

    公开(公告)号：US06764482B2

    公开(公告)日：2004-07-20

    申请号：US10283654

    申请日：2002-10-29

    申请人： Michael R. Keilman ,  Walter A. Makaryk ,  Joseph A. Giertych

    发明人： Michael R. Keilman ,  Walter A. Makaryk ,  Joseph A. Giertych

    IPC分类号： A61B1900

    CPC分类号： A61M1/28 ,  A61J1/00 ,  A61M1/1668 ,  A61M1/1686 ,  Y10S128/24 ,  Y10S206/828 ,  Y10T436/108331

    摘要： A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10) and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).

    摘要翻译： 提供双填充双袋，包括双包的包装以及用于形成包装的双袋的方法。 至少部分地用溶液（14）填充两个袋子中的每个袋，溶液袋（10）和用于腹膜透析程序的系统的排液袋（12）。 管道组（16）连接两个填充的袋（10,12），并且还可以在制造过程中填充有添加到袋（10,12）和管组（16）中的溶液（14）。 或者，管组（16）可以填充空气。 管套（16）夹在溶液袋（10）和排放袋（12）之间，随后包装在一个外袋（24）中。 用于形成包括填充有溶液的袋的包装的方法被简化，并且由于溶液袋（10,12）之间的夹套管组（16）和在两个袋（10,12）中提供溶液，整体包装尺寸减小， 12）。

    Dual-filled twin bag, a package and a method for forming a package administering a solution
    2.
    发明授权
    Dual-filled twin bag, a package and a method for forming a package administering a solution 失效
    双填充双袋，包装和形成包装的方法

    公开(公告)号：US06508800B1

    公开(公告)日：2003-01-21

    申请号：US09349688

    申请日：1999-07-08

    申请人： Michael R. Keilman ,  Walter A. Makaryk ,  Joseph A. Giertych

    发明人： Michael R. Keilman ,  Walter A. Makaryk ,  Joseph A. Giertych

    IPC分类号： A61B1900

    CPC分类号： A61M1/28 ,  A61J1/00 ,  A61M1/1668 ,  A61M1/1686 ,  Y10S128/24 ,  Y10S206/828 ,  Y10T436/108331

    摘要： A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10)and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).

    摘要翻译： 提供双填充双袋，包括双包的包装以及用于形成包装的双袋的方法。 至少部分地用溶液（14）填充两个袋子中的每个袋，溶液袋（10）和用于腹膜透析程序的系统的排液袋（12）。 管道组（16）连接两个填充的袋（10,12），并且还可以在制造过程中填充有添加到袋（10,12）和管组（16）的溶液（14）。 或者，管组（16）可以填充空气。 管套（16）夹在溶液袋（10）和排放袋（12）之间，随后包装在一个外袋（24）中。 用于形成包括填充有溶液的袋的包装的方法被简化，并且由于溶液袋（10,12）之间的夹套管组（16）和在两个袋（10,12）中提供溶液，整体包装尺寸减小， 12）。

    METHODS AND COMPOSITIONS FOR DETECTION OF MICROBIAL CONTAMINANTS IN PERITONEAL DIALYSIS SOLUTIONS
    3.
    发明申请
    METHODS AND COMPOSITIONS FOR DETECTION OF MICROBIAL CONTAMINANTS IN PERITONEAL DIALYSIS SOLUTIONS 有权
    用于检测腹膜透析溶液中微生物污染物的方法和组合物

    公开(公告)号：US20100056990A1

    公开(公告)日：2010-03-04

    申请号：US12618442

    申请日：2009-11-13

    申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

    发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

    IPC分类号： A61M1/28 ,  C12Q1/54

    CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

    摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

    摘要翻译： 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。

    Methods and compositions for detection of microbial contaminants in peritoneal dialysis solution
    6.
    发明授权
    Methods and compositions for detection of microbial contaminants in peritoneal dialysis solution 有权
    用于检测腹膜透析溶液中微生物污染物的方法和组合物

    公开(公告)号：US07618392B2

    公开(公告)日：2009-11-17

    申请号：US11457330

    申请日：2006-07-13

    申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

    发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

    IPC分类号： C12Q1/00

    CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

    摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

    摘要翻译： 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。

    Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions
    7.
    发明授权
    Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions 有权
    用于检测腹膜透析溶液中微生物污染物的方法和组合物

    公开(公告)号：US08546097B2

    公开(公告)日：2013-10-01

    申请号：US12618442

    申请日：2009-11-13

    申请人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

    发明人： Leo Martis ,  Mehul Patel ,  Joseph A. Giertych ,  James W. Mongoven ,  Jacqueline A. Kunzler ,  William F. Owen, Jr.

    IPC分类号： C12G1/00

    CPC分类号： A61K31/716 ,  C12Q1/04 ,  G01N2333/4722 ,  Y10S436/815

    摘要： Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions are provided. The methods and compositions employ modified bioburden testing and the detection of peptidoglycan. A novel cause of aseptic peritonitis is provided—aseptic peritonitis associated with gram positive microbial contamination of a dialysis solution. Peptidoglycan is a major component of a gram positive bacterial cell wall and thus can serve as a marker for gram positive bacteria. In this regard, testing for peptidoglycans can be utilized to effectively prevent peritonitis in patients that use the peritoneal dialysis solutions, such as peritoneal dialysis solutions that contain a glucose polymer including an icodextrin and the like.

    摘要翻译： 提供了用于检测腹膜透析溶液中微生物污染物的方法和组合物。 方法和组合物采用修饰的生物负载测试和肽聚糖的检测。 提供无菌性腹膜炎的新原因 - 与透析溶液的革兰氏阳性微生物污染相关的无菌性腹膜炎。 肽聚糖是革兰氏阳性细菌细胞壁的主要成分，因此可以作为革兰氏阳性菌的标记物。 在这方面，可以利用肽聚糖的测试来有效地预防使用腹膜透析溶液的患者腹膜炎，例如含有包含icodextrin等的葡萄糖聚合物的腹膜透析溶液。