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    Apparatus and system for delivery of drug therapies
    1.
    发明授权
    Apparatus and system for delivery of drug therapies 有权
    用于药物治疗的装置和系统

    公开(公告)号：US07722598B2

    公开(公告)日：2010-05-25

    申请号：US11675693

    申请日：2007-02-16

    申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

    发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

    IPC分类号： A61K9/22

    CPC分类号： A61M5/14276 ,  A61M5/14244 ,  A61M5/16813 ,  A61M2205/0266 ,  A61N1/0568

    摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.

    摘要翻译： 一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。 待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。 医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

    Arrangement and system for enabling patient control of electrical therapies
    2.
    发明授权
    Arrangement and system for enabling patient control of electrical therapies 有权
    用于使患者能够控制电疗的安排和系统

    公开(公告)号：US06804554B2

    公开(公告)日：2004-10-12

    申请号：US10053035

    申请日：2001-10-19

    申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Nirav V. Sheth ,  Nancy Perry Pool

    发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Nirav V. Sheth ,  Nancy Perry Pool

    IPC分类号： A61N130

    CPC分类号： A61N1/3956 ,  A61N1/37247 ,  A61N1/37258 ,  A61N1/3987

    摘要： A patient-controlled system for temporarily disabling an electrical cardioverting therapy in order to prepare the patient psychologically and physiologically for the pain associated with electrical cardioversion therapy. In an example embodiment, the system includes a capacitive circuit capable of charging and discharging in order to apply the electrical therapy. The implanted medical device automatically causes the capacitive circuit to charge and discharge at least once within a selected period. The system includes a patient activator device that communicates with the implanted device. A disabling circuit is also included within the implanted medical device that temporarily disables the electrical therapy application in response to the patient activator device. The system further includes an alerting arrangement that alerts the patient activator device in response to the disabling circuit. An override circuit overrides the temporary disabling of the electrical therapy application in response to the patient being in a relaxed mode.

    摘要翻译： 一种患者控制的系统，用于临时禁用电复律治疗，以便心理和生理地为患者提供与电复律治疗相关的疼痛。 在示例性实施例中，系统包括能够进行充电和放电以便施加电疗法的电容电路。 植入的医疗装置自动使电容电路在选定的时间内至少进行一次充电和放电。 该系统包括与植入装置通信的患者激活装置。 在植入式医疗装置中还包括禁用电路，其暂时禁用响应于患者激活装置的电疗应用。 该系统还包括警报装置，其响应于禁用电路来警告患者激活装置。 覆盖电路覆盖响应于患者处于放松模式的电疗治疗应用的暂时禁用。

    Method and system for terminating an atrial arrhythmia
    3.
    发明授权
    Method and system for terminating an atrial arrhythmia 有权
    终止心房心律失常的方法和系统

    公开(公告)号：US07951137B2

    公开(公告)日：2011-05-31

    申请号：US11244764

    申请日：2005-10-06

    申请人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    发明人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    IPC分类号： A61K9/22 ,  A61N1/00 ,  A61B5/04

    CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

    摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

    摘要翻译： 提供了一种方法和系统，用于从患者内部响应于心脏中的心房心律失常，包括从患者内测量至少一个指示心房心律失常的心电图特征，以及从患者内控制药物治疗递送至 响应于测量至少一个心电图特征的患者。 响应于测量至少一个心电图特征，向患者开始药物治疗。 根据本发明的一个方面，在测量至少一个心电图特征之前，药物治疗在患者体内分期。 根据另一示例性实施例，响应于测量至少一个心电图特征，单独起搏或与药物治疗组合，心脏以预定速率从患者体内起搏。

    Apparatus and system for delivery of drug therapies
    6.
    发明授权
    Apparatus and system for delivery of drug therapies 失效
    用于药物治疗的装置和系统

    公开(公告)号：US07186247B2

    公开(公告)日：2007-03-06

    申请号：US10407996

    申请日：2003-04-04

    申请人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

    发明人： Michael R. Ujhelyi ,  Rahul Mehra ,  Xiaoyi Min

    IPC分类号： A61K9/22 ,  A61M31/00

    CPC分类号： A61M5/14276 ,  A61M5/14244 ,  A61M5/16813 ,  A61M2205/0266 ,  A61N1/0568

    摘要： A medical delivery system for delivering a fluid to a desired location within a body that includes a first member having an aperture, and a second member adapted to be positioned over the first member. The fluid to be delivered is contained within a fluid storage device, formed by at least one of the first member and the second member. The medical delivery system includes means for repositioning the first member relative to the second member between a first state preventing passage of the fluid through the aperture and a second state enabling passage of the fluid outward from the fluid storage device through the aperture.

    摘要翻译： 一种用于将流体输送到包括具有孔的第一构件的主体内的期望位置的医疗输送系统，以及适于定位在第一构件上方的第二构件。 待输送的流体被包含在由第一构件和第二构件中的至少一个形成的流体存储装置内。 医疗输送系统包括用于在通过孔的流体的第一状态阻止通道和允许流体从流体存储装置向外通过孔的第二状态之间相对于第二构件重新定位第一构件的装置。

    Method and system for terminating an atrial arrhythmia
    7.
    发明授权
    Method and system for terminating an atrial arrhythmia 失效
    终止心房心律失常的方法和系统

    公开(公告)号：US06968226B2

    公开(公告)日：2005-11-22

    申请号：US10059824

    申请日：2002-01-30

    申请人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    发明人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    IPC分类号： A61B5/0402 ,  A61B5/0472 ,  A61B17/00 ,  A61K31/18 ,  A61M5/142 ,  A61M5/172 ,  A61M37/00 ,  A61N1/362 ,  A61N1/365 ,  A61P9/06 ,  A61B5/04

    CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

    摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

    摘要翻译： 提供了一种方法和系统，用于从患者内部响应于心脏中的心房心律失常，包括从患者内测量至少一个指示心房心律失常的心电图特征，以及从患者内控制药物治疗递送至 响应于测量至少一个心电图特征的患者。 响应于测量至少一个心电图特征，向患者开始药物治疗。 根据本发明的一个方面，在测量至少一个心电图特征之前，药物治疗在患者体内分期。 根据另一示例性实施例，响应于测量至少一个心电图特征，单独起搏或与药物治疗组合，心脏以预定速率从患者体内起搏。

    System and method for patient-controlled relief of pain associated with electrical therapies
    8.
    发明授权
    System and method for patient-controlled relief of pain associated with electrical therapies 有权
    用于患者控制的与电疗法相关的疼痛缓解的系统和方法

    公开(公告)号：US06728574B2

    公开(公告)日：2004-04-27

    申请号：US10040147

    申请日：2001-10-19

    申请人： Michael R. Ujhelyi ,  Rahul Mehra

    发明人： Michael R. Ujhelyi ,  Rahul Mehra

    IPC分类号： A61N100

    CPC分类号： A61N1/3956 ,  A61N1/3987

    摘要： A pain management system that enables a patient to control pain associated with the application of electrical therapies by an implanted device that includes using a non-implanted drug delivery device. In an example embodiment, a pain management system includes an implanted medical device that detects an arrhythmia of a heart and telemetrically communicates from the implanted medical device an arrhythmia condition. The system also includes an external drug delivery arrangement that receives telemetric communications on the arrhythmia condition from the implanted device and provides an alert of the arrhythmia condition to the patient. The external drug delivery arrangement communicates to the implanted device that a drug is being administered to the patient. The implanted medical device includes a capacitive circuit that delivers the electrical therapy to the heart in response to the drug being administered.

    摘要翻译： 一种疼痛管理系统，其使患者能够通过包括使用非植入药物递送装置的植入装置来控制与电疗法的应用相关的疼痛。 在示例性实施例中，疼痛管理系统包括植入式医疗装置，其检测心脏的心律失常并且从植入的医疗装置与心律失常状况进行遥测通信。 该系统还包括外部药物递送装置，其从植入装置接收心律不齐状况的遥测通信，并且向患者提供心律失常状态的警报。 外部药物递送装置与植入装置通信药物被施用于患者。 植入的医疗装置包括电容电路，其响应于施用的药物将电疗法递送到心脏。