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15 条记录 (耗时 0.021 秒)

    Method and system for terminating an atrial arrhythmia
    1.
    发明授权
    Method and system for terminating an atrial arrhythmia 有权
    终止心房心律失常的方法和系统

    公开(公告)号：US07951137B2

    公开(公告)日：2011-05-31

    申请号：US11244764

    申请日：2005-10-06

    申请人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    发明人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    IPC分类号： A61K9/22 ,  A61N1/00 ,  A61B5/04

    CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

    摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

    摘要翻译： 提供了一种方法和系统，用于从患者内部响应于心脏中的心房心律失常，包括从患者内测量至少一个指示心房心律失常的心电图特征，以及从患者内控制药物治疗递送至 响应于测量至少一个心电图特征的患者。 响应于测量至少一个心电图特征，向患者开始药物治疗。 根据本发明的一个方面，在测量至少一个心电图特征之前，药物治疗在患者体内分期。 根据另一示例性实施例，响应于测量至少一个心电图特征，单独起搏或与药物治疗组合，心脏以预定速率从患者体内起搏。

    Method and system for terminating an atrial arrhythmia
    2.
    发明授权
    Method and system for terminating an atrial arrhythmia 失效
    终止心房心律失常的方法和系统

    公开(公告)号：US06968226B2

    公开(公告)日：2005-11-22

    申请号：US10059824

    申请日：2002-01-30

    申请人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    发明人： Rahul Mehra ,  George J. Klein ,  Michael R. Ujhelyi

    IPC分类号： A61B5/0402 ,  A61B5/0472 ,  A61B17/00 ,  A61K31/18 ,  A61M5/142 ,  A61M5/172 ,  A61M37/00 ,  A61N1/362 ,  A61N1/365 ,  A61P9/06 ,  A61B5/04

    CPC分类号： A61M5/14244 ,  A61B2017/00044 ,  A61M5/1723 ,  A61M2230/04 ,  A61N1/3621

    摘要： A method and system is provided for responding, from internally within a patient, to an atrial arrhythmia in a heart including measuring from within the patient at least one electrocardiogram characteristic indicative of the atrial arrhythmia, and controlling from within the patient drug therapy delivery to the patient responsive to measuring the at least one electrocardiogram characteristic. Drug therapy is initiated to the patient responsive to measuring the at least one electrocardiogram characteristic. According to one aspect of the present invention, the drug therapy is staged within the patient prior to measuring the at least one electrocardiogram characteristic. According to another example embodiment, the heart is paced from within the patient at a predefined rate responsive to measuring the at least one electrocardiogram characteristic, pacing occurring alone, or in combination with drug therapy.

    摘要翻译： 提供了一种方法和系统，用于从患者内部响应于心脏中的心房心律失常，包括从患者内测量至少一个指示心房心律失常的心电图特征，以及从患者内控制药物治疗递送至 响应于测量至少一个心电图特征的患者。 响应于测量至少一个心电图特征，向患者开始药物治疗。 根据本发明的一个方面，在测量至少一个心电图特征之前，药物治疗在患者体内分期。 根据另一示例性实施例，响应于测量至少一个心电图特征，单独起搏或与药物治疗组合，心脏以预定速率从患者体内起搏。

    Subcutaneous multi-electrode sensing system, method and pacer
    3.
    发明授权
    Subcutaneous multi-electrode sensing system, method and pacer 失效
    皮下多电极感应系统，方法和起搏器

    公开(公告)号：US5331966A

    公开(公告)日：1994-07-26

    申请号：US168725

    申请日：1993-12-16

    申请人： Tom D. Bennett ,  William J. Combs ,  Kallok, Michael J. ,  Brian B. Lee ,  Rahul Mehra ,  George J. Klein

    发明人： Tom D. Bennett ,  William J. Combs ,  Kallok, Michael J. ,  Brian B. Lee ,  Rahul Mehra ,  George J. Klein

    IPC分类号： A61N1/365 ,  A61B5/0402 ,  A61N1/362 ,  A61N1/375 ,  A61B5/0428

    CPC分类号： A61N1/3686 ,  A61N1/36185 ,  A61N1/3622 ,  A61N1/0504 ,  A61N1/3756 ,  Y10S128/903

    摘要： A method and apparatus for providing an enhanced capability of detecting and gathering electrical cardiac signals via an array of relatively closely spaced subcutaneous electrodes (located on the body of an implanted device) which may be employed with suitable switching circuits, signal processors, and memory to process the electrical cardiac signals between any selected pair or pairs of the electrode array in order to provide a leadless, orientation insensitive means for receiving the electrical signal from the heart. This far-field EGM may be used to provide storage and analysis of arrhythmic events and to provide control signals for the delivery of various therapies including pacing, cardioversion and defibrillation therapies as well as the delivery of antiarrhythmic drugs, and, in the pacing context, to effect capture detection and automatic stimulation threshold adaption, recording of PMT episodes, measurement of refractory periods in order to set timing windows for antitachy pacing therapies, and as a control signal for use in adjusting pacing rate to physiologic demand.

    摘要翻译： 一种用于提供通过相对紧密间隔的皮下电极（位于植入装置的主体上）的阵列来检测和收集电心电信号的增强能力的方法和装置，其可以与合适的开关电路，信号处理器和存储器一起使用 处理任何所选择的一对或一对电极阵列之间的电心脏信号，以便提供用于从心脏接收电信号的无引导方向不敏感的装置。 这种远场EGM可用于提供心律失常事件的存储和分析，并提供用于递送各种疗法的控制信号，包括起搏，心脏复律和除颤疗法以及递送抗心律失常药物，并且在起搏背景下， 以实现捕获检测和自动刺激阈值适应，记录PMT发作，测量不良期以设置反向起搏治疗的时间窗口，以及用作调整生理需求起搏速率的控制信号。

    Intravascular Medical Device
    5.
    发明申请
    Intravascular Medical Device 审中-公开
    血管内医疗器械

    公开(公告)号：US20090198295A1

    公开(公告)日：2009-08-06

    申请号：US12423605

    申请日：2009-04-14

    申请人： Charles L. Dennis ,  George J. Klein ,  Ursula Gebhardt ,  Kenneth M. Anderson ,  Glenn C. Zillmer

    发明人： Charles L. Dennis ,  George J. Klein ,  Ursula Gebhardt ,  Kenneth M. Anderson ,  Glenn C. Zillmer

    IPC分类号： A61N1/39 ,  A61N1/375 ,  A61B17/00

    CPC分类号： A61N1/372 ,  A61N1/37205

    摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.

    摘要翻译： 可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。 系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。 以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。

    Minimally invasive implantable device for monitoring physiologic events
    6.
    发明授权
    Minimally invasive implantable device for monitoring physiologic events 失效
    用于监测生理事件的微创植入式装置

    公开(公告)号：US5987352A

    公开(公告)日：1999-11-16

    申请号：US33678

    申请日：1998-03-03

    申请人： George J. Klein ,  Dwight H. Warkentin ,  Kenneth M. Riff ,  Brian B. Lee ,  James K. Carney ,  Gregg Turi ,  Anthony J. Varrichio

    发明人： George J. Klein ,  Dwight H. Warkentin ,  Kenneth M. Riff ,  Brian B. Lee ,  James K. Carney ,  Gregg Turi ,  Anthony J. Varrichio

    IPC分类号： A61B5/0492 ,  A61B5/0404 ,  A61B5/0408 ,  A61B5/0478 ,  A61N1/375 ,  A61B5/0402

    CPC分类号： A61N1/375

    摘要： A minimally invasive implant, means for insertion, and description of how to most efficiently use it are described n several embodiments. This implant preferably has a segmented looping memory for storing triggered physiologic events. Preferred events for setting autotriggers to record physiologic signals occurring during events include arrhythmias and syncopal events. Preferably the device can function without a microprocessor. An outside device or other patient activated manual trigger is included. Auto triggers and manually set triggers may be of different sizes. The preferred physiologic events are ECG signals. Electrode spacing can be critical. Additional sensors may be provided to the device. Preferred communications with the device is through telemetry such as is used for pacemakers and other implanted devices.

    摘要翻译： 在几个实施例中描述了微创植入物，用于插入的手段和如何最有效地使用它的描述。 该植入物优选地具有用于存储触发的生理事件的分段循环存储器。 设置自动跟踪器记录事件中发生的生理信号的首选事件包括心律失常和晕厥事件。 优选地，该装置可以在没有微处理器的情况下工作。 包括外部设备或其他患者激活的手动触发器。 自动触发器和手动设置触发器可能具有不同的大小。 优选的生理事件是ECG信号。 电极间距可能很重要。 可以向设备提供附加的传感器。 与设备的首选通信是通过诸如用于起搏器和其他植入设备的遥测。

    Deflectable biopsy catheter
    9.
    发明授权
    Deflectable biopsy catheter 失效
    可折叠活检导管

    公开(公告)号：US5957863A

    公开(公告)日：1999-09-28

    申请号：US111350

    申请日：1998-07-07

    申请人： Josef V. Koblish ,  Thomas P. Coen ,  George J. Klein

    发明人： Josef V. Koblish ,  Thomas P. Coen ,  George J. Klein

    IPC分类号： A61B10/00 ,  A61B10/06 ,  A61B17/00 ,  A61B17/28 ,  A61B18/14 ,  A61F2/00 ,  A61M25/01 ,  A61M25/092 ,  A61B5/00

    CPC分类号： A61B10/06 ,  A61B18/1445 ,  A61B18/1492 ,  A61B10/02 ,  A61B2017/00044 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/2905 ,  A61B2017/2946 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61B2018/126 ,  A61B2018/162 ,  A61F2210/0014 ,  A61M25/0147

    摘要： A deflectable biopsy catheter for obtaining a tissue sample from a body cavity of a patient comprising: an axially elongated catheter shaft having proximal and distal portions respectively terminating at proximal and distal ends, the catheter shaft being sized and constructed to be advanced into a body cavity of a patient; a deflection wire coupled to the distal portion of the catheter shaft and extending within the catheter to the proximal end thereof; and a pair of biopsy jaws coupled to the distal end of the catheter shaft and having first and second opposed free cutting surfaces exposable for contact with a selected area of tissue within the patient's body cavity and movable with respect to each other to cut a tissue sample from the selected area of tissue. Schemes for obtaining samples from body cavities (e.g., the gastrointestinal tract, the heart, the intestines, the uterus, the muscles, the bile duct, and the esophagus) are disclosed. Schemes for treating tissue by ablation or by electro-coagulation are also disclosed.

    摘要翻译： 一种用于从患者的体腔获得组织样本的可偏转的活检导管，包括：轴向细长的导管轴，其具有分别在近端和远端终止的近端部分和远端部分，所述导管轴的尺寸和构造被推进到体腔 的病人 耦合到导管轴的远端部分并在导管内延伸到其近端的偏转线; 以及联接到导管轴的远端的一对活检钳，并且具有可暴露于与患者体腔内的组织的选定区域接触并且可相对于彼此移动以切割组织样本的第一和第二相对的自由切割表面 从组织的选定区域。 公开了用于从体腔（例如，胃肠道，心脏，肠，子宫，肌肉，胆管和食道）获得样品的方案。 还公开了通过消融或电凝治疗组织的方案。