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1.发明授权Coating process for drug delivery balloons using heat-induced rewrap memory 有权使用热引起的包裹记忆的药物递送气囊的涂覆方法公开(公告)号：US08889211B2
公开(公告)日：2014-11-18
申请号：US13225166
申请日：2011-09-02
CPC分类号： A61L29/16 , A61L2300/416 , A61L2300/45 , A61L2420/02 , Y10T29/49885
摘要： A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.
摘要翻译： 一种制备药物包衣球囊的方法，包括以下步骤：对其上的折叠和包裹的气囊的球囊导管进行预退火步骤，以在所得预退火球囊中引起折叠/包裹记忆; 通过施加保持所述折叠/包裹存储器的充气压力来充分展开预退火球囊以暴露气球的整个圆周表面; 将药物涂层制剂施用到未折叠的气囊表面; 释放压力以放松气球，并沿折叠记忆引发褶皱; 并缓慢排空球囊以引起气球的再折叠和重新包裹。 该方法克服了使用折叠装置折叠和包裹药物涂覆的气囊的需要。
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2.发明申请Coating Process for Drug Delivery Balloons Using Heat-Induced Rewrap Memory 有权使用热诱导重写存储器的药物递送气球的涂覆过程公开(公告)号：US20120059316A1
公开(公告)日：2012-03-08
申请号：US13225166
申请日：2011-09-02
CPC分类号： A61L29/16 , A61L2300/416 , A61L2300/45 , A61L2420/02 , Y10T29/49885
摘要： A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.
摘要翻译： 一种制备药物包衣球囊的方法，包括以下步骤：对其上的折叠和包裹的气囊的球囊导管进行预退火步骤，以在所得预退火球囊中引起折叠/包裹记忆; 通过施加保持所述折叠/包裹存储器的充气压力来充分展开预退火球囊以暴露气球的整个圆周表面; 将药物涂层制剂施用到未折叠的气囊表面; 释放压力以放松气球，并沿折叠记忆引发褶皱; 并缓慢排空球囊以引起气球的再折叠和重新包裹。 该方法克服了使用折叠装置折叠和包裹药物涂覆的气囊的需要。
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