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    Coating process for drug delivery balloons using heat-induced rewrap memory
    1.
    发明授权
    Coating process for drug delivery balloons using heat-induced rewrap memory 有权
    使用热引起的包裹记忆的药物递送气囊的涂覆方法

    公开(公告)号：US08889211B2

    公开(公告)日：2014-11-18

    申请号：US13225166

    申请日：2011-09-02

    申请人： Michael Sean Owens ,  Michael Swee ,  Dennis Larson ,  Stacie Blaskowsi

    发明人： Michael Sean Owens ,  Michael Swee ,  Dennis Larson ,  Stacie Blaskowsi

    IPC分类号： A61L33/00 ,  A61L29/16

    CPC分类号： A61L29/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2420/02 ,  Y10T29/49885

    摘要： A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.

    摘要翻译： 一种制备药物包衣球囊的方法，包括以下步骤：对其上的折叠和包裹的气囊的球囊导管进行预退火步骤，以在所得预退火球囊中引起折叠/包裹记忆; 通过施加保持所述折叠/包裹存储器的充气压力来充分展开预退火球囊以暴露气球的整个圆周表面; 将药物涂层制剂施用到未折叠的气囊表面; 释放压力以放松气球，并沿折叠记忆引发褶皱; 并缓慢排空球囊以引起气球的再折叠和重新包裹。 该方法克服了使用折叠装置折叠和包裹药物涂覆的气囊的需要。

    Coating Process for Drug Delivery Balloons Using Heat-Induced Rewrap Memory
    2.
    发明申请
    Coating Process for Drug Delivery Balloons Using Heat-Induced Rewrap Memory 有权
    使用热诱导重写存储器的药物递送气球的涂覆过程

    公开(公告)号：US20120059316A1

    公开(公告)日：2012-03-08

    申请号：US13225166

    申请日：2011-09-02

    申请人： Michael S. Owens ,  Michael Swee ,  Dennis Larson ,  Stacie Blaskowsi

    发明人： Michael S. Owens ,  Michael Swee ,  Dennis Larson ,  Stacie Blaskowsi

    IPC分类号： A61M29/00 ,  B05D3/00 ,  B05D7/00 ,  B23P25/00 ,  B05D5/00

    CPC分类号： A61L29/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2420/02 ,  Y10T29/49885

    摘要： A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap memory in the resulting pre-annealed balloon; unfolding the pre-annealed balloon sufficiently to expose the full circumferential surface of the balloon by application of an inflation pressure that retains said fold/wrap memory; applying a drug coating formulation to the unfolded balloon surface; releasing pressure to relax the balloon and induce creasing along fold memory; and evacuating the balloon slowly to induce refolding and rewrapping of the balloon. The method overcomes the need to use a folding apparatus to fold and wrap a drug coated balloon.

    摘要翻译： 一种制备药物包衣球囊的方法，包括以下步骤：对其上的折叠和包裹的气囊的球囊导管进行预退火步骤，以在所得预退火球囊中引起折叠/包裹记忆; 通过施加保持所述折叠/包裹存储器的充气压力来充分展开预退火球囊以暴露气球的整个圆周表面; 将药物涂层制剂施用到未折叠的气囊表面; 释放压力以放松气球，并沿折叠记忆引发褶皱; 并缓慢排空球囊以引起气球的再折叠和重新包裹。 该方法克服了使用折叠装置折叠和包裹药物涂覆的气囊的需要。

    COMPOSITE GUIDEWIRE
    5.
    发明申请
    COMPOSITE GUIDEWIRE 有权
    复合指南

    公开(公告)号：US20070244414A1

    公开(公告)日：2007-10-18

    申请号：US11763973

    申请日：2007-06-15

    申请人： Brian Reynolds ,  Peter Skujins ,  Brice Shireman ,  Bruce Asmus ,  Ron Tanaka ,  Michael Swee

    发明人： Brian Reynolds ,  Peter Skujins ,  Brice Shireman ,  Bruce Asmus ,  Ron Tanaka ,  Michael Swee

    IPC分类号： A61M25/01

    CPC分类号： A61M25/0905 ,  A61L31/022 ,  A61M25/09 ,  A61M2025/09141 ,  A61M2025/09175

    摘要： Alternative designs, materials and manufacturing methods for guidewires. Some embodiments pertain to a composite guidewire having proximal and distal section, and a connector adapted and configured for permanently joining the proximal section to the distal section. In some embodiments, at least one of the sections is made of a linear-elastic nickel-titanium alloy. Several alternative guidewire tip designs including coiled safety/shaping structures are also disclosed.

    摘要翻译： 导线的替代设计，材料和制造方法。 一些实施例涉及具有近端和远端部分的复合导丝，以及适于和构造用于将近端部分永久地连接到远端部分的连接器。 在一些实施例中，至少一个部分由线性弹性镍钛合金制成。 还公开了包括卷绕的安全/成形结构的几种替代的导线尖端设计。