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    Pharmacokinetic-based culture system with biological barriers
    9.
    发明申请
    Pharmacokinetic-based culture system with biological barriers 审中-公开
    基于药物动力学的生物屏障培养体系

    公开(公告)号：US20070037277A1

    公开(公告)日：2007-02-15

    申请号：US11436100

    申请日：2006-05-17

    申请人： Michael Shuler ,  Gregory Baxter ,  Aaron Sin ,  Andrew Harrison ,  Scott Meyers ,  Robert Freedruan

    发明人： Michael Shuler ,  Gregory Baxter ,  Aaron Sin ,  Andrew Harrison ,  Scott Meyers ,  Robert Freedruan

    IPC分类号： C12M3/00

    CPC分类号： C12M23/34 ,  B01L3/5027 ,  C12M21/08 ,  C12M23/16 ,  C12M23/44 ,  C12M29/04

    摘要： Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.

    摘要翻译： 公开了用于微量药代动力学的系统和方法。 各种器官及其与药物化合物的相互作用可以通过使用可通过微量通道相互连接的微小室进行体外模拟。 与器官相关的细胞或细胞材料可以在这些隔室中培养以允许与一种或多种流体流中药物化合物的相互作用。 这样的流体系统可以包括例如胃肠道流动，血流量，胆汁流量，尿流量和脑液流量。 流体系统之间的相互作用可以通过微量可渗透构件进行模拟。 在一个实例中，可以通过具有通过粘合剂结合到可渗透底物的肝细胞的微量可渗透材料来模拟血液 - 胆汁相互作用。