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    MASS SPECTROMETER OUTPUT ANALYSIS TOOL FOR IDENTIFICATION OF PROTEINS
    1.
    发明申请
    MASS SPECTROMETER OUTPUT ANALYSIS TOOL FOR IDENTIFICATION OF PROTEINS 审中-公开
    质谱仪输出分析用于鉴定蛋白质的工具

    公开(公告)号：US20100280759A1

    公开(公告)日：2010-11-04

    申请号：US12473005

    申请日：2009-05-27

    申请人： Oren Kagan ,  James R. Dasch ,  Aaron Sin

    发明人： Oren Kagan ,  James R. Dasch ,  Aaron Sin

    IPC分类号： G06F19/00 ,  G01N33/68

    CPC分类号： G16B45/00 ,  G16B30/00 ,  G16B50/00

    摘要： Methods and apparatus for consolidation and visualization of a dataset output from a mass spectrometer. The number of proteins identified in a mass spectrometry experiment may be systematically reduced by identifying and excluding proteins which may not be necessary to explain the observed peptides in a sample. Peptide counts from excluded proteins may be redistributed to non-excluded proteins to preserve total observed peptide counts. The consolidated dataset may be represented as a data structure having a plurality of cells arranged into rows and columns. Visual parameter values may be assigned to various cells in the data structure to emphasize particular features of the data. Data from multiple samples may be arranged in sets of columns in the data structure, and difference scores may be calculated to determine peptide expression differences between the multiples samples. The difference scores may be displayed using textual and/or graphical representations to facilitate data analysis.

    摘要翻译： 用于整合和显示质谱仪输出的数据集的方法和装置。 通过鉴定和排除可能不需要解释样品中观察到的肽的蛋白质，可以系统地减少在质谱实验中鉴定的蛋白质的数量。 来自排除蛋白的肽计数可以重新分配到未排除的蛋白质以保留总观察到的肽计数。 统一数据集可以表示为具有排列成行和列的多个单元的数据结构。 可视参数值可以分配给数据结构中的各个单元，以强调数据的特定特征。 来自多个样本的数据可以以数据结构中的列的形式排列，并且可以计算差分以确定多个样本之间的肽表达差异。 可以使用文本和/或图形表示来显示差异分数以促进数据分析。

    Biliary barrier
    4.
    发明申请
    Biliary barrier 审中-公开
    胆道屏障

    公开(公告)号：US20070048727A1

    公开(公告)日：2007-03-01

    申请号：US11436042

    申请日：2006-05-17

    申请人： Michael Shuler ,  Gregory Baxter ,  Aaron Sin ,  Andrew Harrison ,  Scott Meyers ,  Robert Freedman

    发明人： Michael Shuler ,  Gregory Baxter ,  Aaron Sin ,  Andrew Harrison ,  Scott Meyers ,  Robert Freedman

    IPC分类号： C12M3/00

    CPC分类号： C12M23/34 ,  B01L3/5027 ,  C12M21/08 ,  C12M23/16 ,  C12M23/44 ,  C12M29/04 ,  C12M35/08

    摘要： Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.

    摘要翻译： 公开了用于微量药代动力学的系统和方法。 各种器官及其与药物化合物的相互作用可以通过使用可通过微量通道相互连接的微小室进行体外模拟。 与器官相关的细胞或细胞材料可以在这些隔室中培养以允许与一种或多种流体流中药物化合物的相互作用。 这样的流体系统可以包括例如胃肠道流动，血流量，胆汁流量，尿流量和脑液流量。 流体系统之间的相互作用可以通过微量可渗透构件进行模拟。 在一个实例中，可以通过具有通过粘合剂结合到可渗透底物的肝细胞的微量可渗透材料来模拟血液 - 胆汁相互作用。

    Devices and methods for pharmacokinetic-based cell culture system
    6.
    发明授权
    Devices and methods for pharmacokinetic-based cell culture system 有权
    基于药物动力学的细胞培养系统的装置和方法

    公开(公告)号：US09273276B2

    公开(公告)日：2016-03-01

    申请号：US13301261

    申请日：2011-11-21

    申请人： Michael Shuler ,  Gregory T. Baxter ,  Aaron Sin ,  Robert Andrew Harrison ,  Scott Meyers

    发明人： Michael Shuler ,  Gregory T. Baxter ,  Aaron Sin ,  Robert Andrew Harrison ,  Scott Meyers

    IPC分类号： C12M1/34 ,  C12M3/06 ,  C12M3/00 ,  C12M1/36 ,  G01N33/50 ,  C12N5/071 ,  C12N5/00

    CPC分类号： C12M41/46 ,  C12M23/16 ,  C12M23/44 ,  C12M41/48 ,  C12N5/0062 ,  C12N5/0671 ,  G01N33/5008 ,  G01N33/5067

    摘要： A cell culture method using an in vitro microscale cell culture device having a first microscale chamber containing cells attached to an inner surface of the chamber and cell culture medium in contact with the cells. The cells are maintained in culture in the in vitro microscale cell culture device while flowing culture medium through the first chamber at a controlled rate to provide a liquid residence time value for the cells in the first chamber of the in vitro microscale cell culture device that is comparable to a liquid residence time value obtained with respect to comparable cells in vivo, such that metabolism by the cells in culture in the in vitro microscale cell culture device is comparable to metabolism by comparable cells in vivo.

    摘要翻译： 一种使用体外微细胞培养装置的细胞培养方法，所述培养装置具有包含连接于所述腔室内表面的细胞的第一微量室和与细胞接触的细胞培养基。 将细胞在体外微量细胞培养装置中保持培养，同时以受控的速率流过培养基通过第一室，以提供体外微量细胞培养装置的第一室中的细胞的液体停留时间值，其为 相当于在体内相当的细胞获得的液体停留时间值，使得体外微量细胞培养装置中培养物中的细胞的代谢与体内相当的细胞的代谢相当。

    Pharmacokinetic-based culture system with biological barriers
    10.
    发明申请
    Pharmacokinetic-based culture system with biological barriers 审中-公开
    基于药物动力学的生物屏障培养体系

    公开(公告)号：US20070037277A1

    公开(公告)日：2007-02-15

    申请号：US11436100

    申请日：2006-05-17

    申请人： Michael Shuler ,  Gregory Baxter ,  Aaron Sin ,  Andrew Harrison ,  Scott Meyers ,  Robert Freedruan

    发明人： Michael Shuler ,  Gregory Baxter ,  Aaron Sin ,  Andrew Harrison ,  Scott Meyers ,  Robert Freedruan

    IPC分类号： C12M3/00

    CPC分类号： C12M23/34 ,  B01L3/5027 ,  C12M21/08 ,  C12M23/16 ,  C12M23/44 ,  C12M29/04

    摘要： Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member. In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes bound to a permeable substrate via a binder.

    摘要翻译： 公开了用于微量药代动力学的系统和方法。 各种器官及其与药物化合物的相互作用可以通过使用可通过微量通道相互连接的微小室进行体外模拟。 与器官相关的细胞或细胞材料可以在这些隔室中培养以允许与一种或多种流体流中药物化合物的相互作用。 这样的流体系统可以包括例如胃肠道流动，血流量，胆汁流量，尿流量和脑液流量。 流体系统之间的相互作用可以通过微量可渗透构件进行模拟。 在一个实例中，可以通过具有通过粘合剂结合到可渗透底物的肝细胞的微量可渗透材料来模拟血液 - 胆汁相互作用。