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公开(公告)号：US06177062B1
公开(公告)日：2001-01-23
申请号：US08474468
申请日：1995-06-07
IPC分类号： A61B5055
CPC分类号： B82Y5/00 , A61K49/228
摘要： The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.
摘要翻译： 本发明涉及包含微粒的超声造影剂，其包含合成的可生物降解聚合物和沸点低于60℃的气体和/或流体，其制备方法及其作为诊断和治疗剂的用途。
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2.发明授权Ultrasonic contrast agents, process for their preparation and their use as a diagnostic and therapeutic agent 失效超声造影剂，其制备方法及其作为诊断和治疗剂的用途公开(公告)号：US06264959B1
公开(公告)日：2001-07-24
申请号：US07536373
申请日：1990-06-11
IPC分类号： A61K900
CPC分类号： B82Y5/00 , A61K49/228
摘要： The invention relates to ultrasonic contrast agents consisting of microparticles which consist of amyloses and synthetic biodegradable polymers and a gas and/or a fluid with a boiling point below 60° C., process for the preparation thereof and their use as diagnostic and therapeutic agents.
摘要翻译： 本发明涉及由由淀粉和合成可生物降解聚合物组成的微粒和沸点低于60℃的气体和/或流体组成的超声造影剂，其制备方法及其作为诊断和治疗剂的用途。
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3.发明授权Polyalkylcyanoacrylate agents and methods for enhancing contrast in ultrasound imaging 失效聚氰基氰基丙烯酸酯试剂和用于增强超声成像中的对比度的方法
公开(公告)号：US6071496A
公开(公告)日：2000-06-06
申请号：US477642
申请日：1995-06-07
申请人： Michael Stein , Dieter Heldmann , Thomas Fritzsch , Joachim Siegert , Georg Roessling , Ulrich Speck
发明人： Michael Stein , Dieter Heldmann , Thomas Fritzsch , Joachim Siegert , Georg Roessling , Ulrich Speck
CPC分类号： B82Y5/00 , A61K49/228
摘要： The invention relates to ultrasonic contrast agents comprising microparticles which comprise synthetic biodegradable polymer which is a polyalkylcyanoarylate and a gas and/or a fluid with a boiling point below 60.degree. C., processes for the preparation thereof and their use as diagnostic and therapeutic agents.
摘要翻译： 本发明涉及包含微粒的超声造影剂，其包含合成的可生物降解的聚合物，其是聚氰基氰化芳基化合物和气体和/或沸点低于60℃的流体，其制备方法及其作为诊断和治疗剂的用途。
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公开(公告)号：US5425366A
公开(公告)日：1995-06-20
申请号：US72748
申请日：1993-06-07
CPC分类号： B82Y5/00 , A61K49/226 , A61K49/228 , G01S15/8979
摘要： The invention relates to a method for obtaining an ultrasonic image of a patient with ultrasonic color Doppler modality with microparticulate ultrasonic contrast agents in regions where the ultrasonic contrast agents are essentially motionless.
摘要翻译： 本发明涉及一种在超声造影剂基本上不动的区域中用微粒超声造影剂获得具有超声彩色多普勒模式的患者的超声波图像的方法。
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公开(公告)号：US06306366B1
公开(公告)日：2001-10-23
申请号：US09129953
申请日：1998-08-06
IPC分类号： A61B800
CPC分类号： B01J13/02 , A61K49/223 , C07C19/08 , Y02P20/582
摘要： Compositions containing microparticles having at least one surface-active substance and at least one non-surface-active solid with a gaseous component containing a halogenated hydrocarbon that is gaseous at body temperature, wherein the gaseous component is more poorly water-soluble than air. Also, ultrasonic contrast media containing such composition, processes for their production, kits for their production and methods of use.
摘要翻译： 含有具有至少一种表面活性物质的微粒和至少一种含有含有在体温下为气态的卤代烃的气态成分的非表面活性固体的组合物，其中气态组分比空气更难溶于水。 此外，含有这种组合物的超声波造影剂，其生产方法，用于其生产的试剂盒和使用方法。
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6.发明授权公开(公告)号：US06284280B1
公开(公告)日：2001-09-04
申请号：US09459578
申请日：1999-12-13
IPC分类号： B01J1304
CPC分类号： A61K41/0028 , A61K9/0009 , A61K9/1635 , A61K9/1647 , A61K49/223 , Y10S977/773 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： The invention relates to new microparticles containing active ingredients, which contain at least one gas or a gaseous phase in addition to the active ingredient(s), agents containing these particles (microparticulate systems), their use for ultrasound-controlled in vivo release of active ingredients, as well as a process for the production of particles and agents.
摘要翻译： 本发明涉及含有活性成分的新的微粒，其除了活性成分之外还含有至少一种气体或气相，含有这些颗粒的试剂（微粒体系），它们用于超声控制体内释放活性成分 成分，以及生产颗粒和试剂的方法。
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公开(公告)号：US06383470B1
公开(公告)日：2002-05-07
申请号：US08897319
申请日：1997-07-21
IPC分类号： A61K4904
CPC分类号： A61K49/226 , A61K49/223
摘要： The invention relates to microparticle preparations made of biodegradable copolymers for use in treatment and diagnosis, especially ultrasonic diagnosis, as well as a process for their production.
摘要翻译： 本发明涉及由用于治疗和诊断，特别是超声波诊断的可生物降解共聚物制成的微粒制剂及其生产方法。
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8.发明授权
公开(公告)号：US6068857A
公开(公告)日：2000-05-30
申请号：US605174
申请日：1996-08-05
IPC分类号： A61K9/00 , A61K9/16 , A61K9/19 , A61K9/50 , A61K41/00 , A61K49/00 , A61K49/22 , A61K9/52 , B01J3/04 , B01J13/04
CPC分类号： A61K41/0028 , A61K49/223 , A61K9/0009 , A61K9/1635 , A61K9/1647 , Y10S977/773 , Y10S977/915 , Y10S977/927 , Y10S977/929
摘要： The invention relates to new microparticles containing active ingredients, which contain at least one gas or a gaseous phase in addition to the active ingredient(s), agents containing these particles (microparticulate systems), their use for ultrasound-controlled in vivo release of active ingredients, as well as a process for the production of particles and agents.
摘要翻译： PCT No.PCT / EP94 / 02806 Sec。 371日期：1996年8月5日 102（e）日期1996年8月5日PCT 1994年8月25日PCT公布。 公开号WO95 / 07072 日期：1995年3月16日本发明涉及含有活性成分的新型微粒，除了活性成分以外含有至少一种气体或气相，含有这些颗粒的试剂（微粒体系），它们用于超声控制 活性成分的体内释放，以及生产颗粒和试剂的方法。
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公开(公告)号：US5410516A
公开(公告)日：1995-04-25
申请号：US76221
申请日：1993-06-14
CPC分类号： G01S7/52038 , A61B8/00 , G01N2291/02491 , G01S15/8979
摘要： A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein a material is introduced in the examination area to be acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.
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公开(公告)号：US06221017B1
公开(公告)日：2001-04-24
申请号：US09432123
申请日：1999-11-02
IPC分类号： A61B800
CPC分类号： G01S7/52038 , A61B8/00 , G01N2291/02491 , G01S15/8979
摘要： A process for selective graphic representation and/or evaluation of the Doppler spectrum of objects limitedly resistant to sonic intensity, for example biological organs and tissues, by an ultrasonic process wherein an examination area is acoustically irradiated, nonlinear oscillations are produced in the examination area by irradiated ultrasonic waves and the signal is evaluated by an ultrasonic converter. Also, a circuit for carrying out the above process is disclosed.
摘要翻译： 通过超声波处理对声音强度有限地抵抗声波强度的物体（例如生物器官和组织）进行选择性图形表示和/或评估的过程，其中检查区域被声学照射，在检查区域中产生非线性振荡 照射超声波，并且通过超声波转换器来评估信号。 另外，公开了用于执行上述处理的电路。
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