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公开(公告)号：US07662782B2
公开(公告)日：2010-02-16
申请号：US11319584
申请日：2005-12-29
IPC分类号： A61K38/00
CPC分类号： C07K14/685 , A61K38/00
摘要： The invention relates to methods of treatment comprising administering a compound of the general formula (1): to a patient or a healthy individual.
摘要翻译： 本发明涉及治疗方法，其包括向患者或健康个体施用通式（1）的化合物：
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公开(公告)号：US20070027086A1
公开(公告)日：2007-02-01
申请号：US11319584
申请日：2005-12-29
CPC分类号： C07K14/685 , A61K38/00
摘要： The invention relates to methods of treatment comprising administering a compound of the general formula (1): to a patient or a healthy individual.
摘要翻译： 本发明涉及治疗方法，其包括向患者或健康个体施用通式（1）的化合物：
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公开(公告)号：US07008925B1
公开(公告)日：2006-03-07
申请号：US09674733
申请日：1999-05-05
IPC分类号： A61K38/00
CPC分类号： C07K14/685 , A61K38/00
摘要： A compound of general formula (1) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are H or methyl, R13, R14, R15 and R16 are H or alkyl, wherein L1 and L2 are linkers selected from single bond, methyl, ethyl, wherein R19, R20 and R21 are H or —CH2X, NT is selected from H, hydroxyl, alkyl, aminoacid, aminoacid analogue, polypeptide and functional group, CT is selected from hydrogen, hydroxyl, alkyl, aminoacid, aminoacid analogue, polypeptide and functional group shows high selectivity and high affinity for MC1-receptors in combination with effective stimulation or inhibiton of cAMP formation in MC1-receptor expressing cells but low affinity for other subtypes of MC-receptors and may be used to treat a wide range of inflammatory conditions. Also disclosed is a DNA molecule and a corresponding vector encoding the compound, a fusion protein comprising a copy of it, a vector comprising DNA encoding the fusion protein, and a pharmaceutical composition comprising the compound.
摘要翻译： 通式（1）的化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11和R 12为H或甲基，R 13，R 14，R 15和R 16为H或烷基， L1和L2是选自单键，甲基，乙基的连接体，其中R 19，R 20和R 21是H或-CH 2 X，NT选自H，羟基，烷基，氨基酸，氨基酸类似物， 多肽和官能团，CT选自氢，羟基，烷基，氨基酸，氨基酸类似物，多肽和官能团对MC1受体具有高选择性和高亲和力，并与MC1受体表达细胞中有效刺激或抑制cAMP形成相结合 但对MC-受体的其它亚型的亲和力低，可用于治疗广泛的炎性病症。 还公开了编码该化合物的DNA分子和相应的载体，包含其拷贝的融合蛋白，包含编码融合蛋白的DNA的载体和包含该化合物的药物组合物。
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公开(公告)号：US06898794B2
公开(公告)日：2005-05-24
申请号：US09933779
申请日：2001-08-21
CPC分类号： H04L41/0896
摘要： The present invention relates to improvements for managing remote function calls and other mechanisms for managing the remote invocation and control of programs. A separation of the request-driven communication work from one broad unstructured bulk of work into at least two separate portions of management is proposed: a dispatching portion and one or more connection portions. Connections are not closed but are reused whenever advantageous, which yields better performance. A standardized interface is set up which is able to be used by a plurality of different requester applications. Thus, a way is found to pass a RFC connection from one application to another, and the same RFC connection can be used by totally independent applications.
摘要翻译： 本发明涉及用于管理远程函数调用的改进和用于管理程序的远程调用和控制的其他机制。 提出了将请求驱动的通信工作从一个广泛的非结构化的大量工作分离成至少两个分开的管理部分：调度部分和一个或多个连接部分。 连接不关闭，但每当有利时重复使用，从而产生更好的性能。 建立了能够被多个不同的请求者应用使用的标准化接口。 因此，发现一种方法将RFC连接从一个应用程序传递到另一个应用程序，并且完全独立的应用程序可以使用相同的RFC连接。
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5.发明授权System and method for selecting symbols and displaying their graphics objects in a detail window 失效用于在详细窗口中选择符号并显示其图形对象的系统和方法
公开(公告)号：US5504853A
公开(公告)日：1996-04-02
申请号：US933425
申请日：1992-08-21
CPC分类号： G06F3/04845
摘要： A display tool is used to simplify the display of a plurality of graphical objects on a display screen. The tool allows a user to select from an inventory of fragments which are required to build a figure. These figures can have child and grandchild elements associated with them. Each figure also has a symbol associated with it. On the display device, an overview window is produced on which graphic objects are shown in symbol form. An arbitrary subset of symbols in the overview window is selected by the user and produces a detail window showing graphical objects or symbols corresponding to the subset of symbols in more detail. These graphical objects are displayed using either their fragment form or their symbol form based on a threshold value as to eliminate overcrowding of screen space. Child and grandchild figure can be directly observed in the detail window by zooming into the selected figure.
摘要翻译： 显示工具用于简化显示屏上的多个图形对象的显示。 该工具允许用户从构建数字所需的碎片的清单中进行选择。 这些数字可能有与他们相关联的子孙元素。 每个图也有一个与之相关联的符号。 在显示设备上，产生一个概览窗口，其中以符号形式显示图形对象。 概览窗口中任意的符号子集由用户选择，并产生一个细节窗口，其中更详细地显示了对应于符号子集的图形对象或符号。 这些图形对象使用其片段形式或其符号形式基于阈值来显示，以消除屏幕空间的过度拥挤。 可以通过放大所选图形，在详细信息窗口中直接观察儿童和孙子人物。
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公开(公告)号：US20140162303A1
公开(公告)日：2014-06-12
申请号：US14026022
申请日：2013-09-13
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , A61K47/542 , G01N33/532 , G01N33/533
摘要： Method for marking a target structure, comprising the following steps: a) providing a compound V that includes at least one dihydroxy- or trihydroxyphenyl group, b) providing a means for converting the dihydroxy- or trihydroxyphenyl group to a quinone group, c) providing a target structure, d) oxidising the dihydroxy- or trihydroxyphenyl group of the compound V to the quinone group, and e) contacting the compound V with the target structure, so that a covalent bond can be formed, wherein in step e) the compound V is used in a concentration such that the maximum concentration of dihydroxy-, trihydroxyphenyl groups and quinone groups that are introduced by the compound V is ≦500 μM, preferably ≦300 μM, and more preferably ≦100 μM.
摘要翻译： 用于标记靶结构的方法，包括以下步骤：a）提供包含至少一个二羟基或三羟基苯基的化合物V，b）提供将二羟基或三羟基苯基转化为醌基的方法，c）提供 目标结构，d）将化合物V的二羟基或三羟基苯基氧化成醌基，e）使化合物V与靶结构物接触，从而可以形成共价键，其中在步骤e）中，化合物 V的浓度使得由化合物V引入的二羟基 - ，三羟基苯基和醌基的最大浓度为500μM，优选为＆lt; nEE;300μM，更优选为＆lt; nEE;100μM。
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公开(公告)号：US20060132837A1
公开(公告)日：2006-06-22
申请号：US11019140
申请日：2004-12-20
申请人： Michael Barth , Michael Szardenings
发明人： Michael Barth , Michael Szardenings
IPC分类号： G06F3/12
CPC分类号： G06F3/1208 , G06F3/126 , G06F3/1285
摘要： A print request is received at a reusable software component of a server and forwarded to a server application. The server application provides in response to the print request print data to the server's reusable software component, which, in turn, sends a second print request and forwards the print data from an interface of the server's reusable software component to the client. The client receives the second print request and print data at an interface of a reusable software component of the client; and forwards the print data to a spool system of the client in response to the second print request.
摘要翻译： 在服务器的可重用软件组件上接收到打印请求，并将其转发到服务器应用程序。 服务器应用程序响应于打印请求打印数据提供给服务器的可重用软件组件，该组件又发送第二打印请求，并将打印数据从服务器的可重用软件组件的接口转发到客户端。 客户端在客户端的可重用软件组件的接口处接收第二打印请求并打印数据; 并且响应于第二打印请求将打印数据转发到客户端的假脱机系统。
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公开(公告)号：US20050266044A1
公开(公告)日：2005-12-01
申请号：US11113314
申请日：2005-04-22
申请人： Michael Szardenings
发明人： Michael Szardenings
IPC分类号： A61L27/28 , A61L27/54 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/16 , A61M36/14 , A61K51/00
摘要： The invention provides a method for modulating the surface characteristics of a device, which is at least temporarily in contact with, a body fluid and/or a body tissue, which is characterized in that the device is coated at least with a ligand that binds at least one of the body's own molecules, wherein the modulation effect is caused substantially by the body's own molecule. The invention thus relies on an auto-protection principle wherein the patient's own substances are used in order to modulate the surface characteristics. Furthermore devices are disclosed which are capable of presenting a modulated surface.
摘要翻译： 本发明提供了一种用于调节与体液和/或身体组织至少暂时接触的装置的表面特性的方法，其特征在于，该装置至少涂覆有结合于 身体自身分子中的至少一个，其中调节作用基本上由身体自身的分子引起。 因此，本发明依赖于自动保护原理，其中使用患者自身的物质来调节表面特征。 此外，公开了能够呈现调制表面的装置。
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