专利检索 ap:("Michel ALETRU" OR "Peter ARANYI" OR "Maria BALOGH" OR "Sandor BATORI" OR "Judit BENCE" OR "Philippe BOVY" OR "Zoltan KAPUI" OR "Endre MIKUS" OR "Claudie NAMANE" OR "Christophe PHILIPPO" OR "Tibor SZABO" OR "Zsuzsanna TOMOSKOZI" OR "Katalin URBAN-SZABO") AND inv:"Claudie NAMANE" 第 1 页

1.

发明申请
PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS 有权
标题翻译：吡唑衍生物及其作为OREXIN受体拮抗剂的用途

公开(公告)号：US20070021459A1

公开(公告)日：2007-01-25

申请号：US11425583

申请日：2006-06-21

申请人： Michel ALETRU , Peter ARANYI , Maria BALOGH , Sandor BATORI , Judit BENCE , Philippe BOVY , Zoltan KAPUI , Endre MIKUS , Claudie NAMANE , Christophe PHILIPPO , Tibor SZABO , Zsuzsanna TOMOSKOZI , Katalin URBAN-SZABO

发明人： Michel ALETRU , Peter ARANYI , Maria BALOGH , Sandor BATORI , Judit BENCE , Philippe BOVY , Zoltan KAPUI , Endre MIKUS , Claudie NAMANE , Christophe PHILIPPO , Tibor SZABO , Zsuzsanna TOMOSKOZI , Katalin URBAN-SZABO

IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/415 , C07D403/14 , C07D403/02 , C07D231/14

CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14

摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.

摘要翻译： 本发明涉及食欲素受体拮抗剂通式（I）化合物及其异构体，盐和溶剂合物，其含有它们的药物组合物及其治疗应用。

2.

发明申请
UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 审中-公开
标题翻译： TROPANE的尿素衍生物及其制备及其治疗应用

公开(公告)号：US20100324084A1

公开(公告)日：2010-12-23

申请号：US12871403

申请日：2010-08-30

申请人： Michel ALETRU , Alain Jean BRAUN , Claudie NAMANE , Olivier VENIER , Christophe PHILIPPO , Patrick MOUGENOT , Eric NICOLAI , Stefan GUSSREGEN

发明人： Michel ALETRU , Alain Jean BRAUN , Claudie NAMANE , Olivier VENIER , Christophe PHILIPPO , Patrick MOUGENOT , Eric NICOLAI , Stefan GUSSREGEN

IPC分类号： A61K31/46 , C07D401/14 , A61P3/10 , A61P3/04 , A61P5/50 , A61P9/12 , A61P9/10 , A61P27/06 , A61P25/28 , A61P19/10

CPC分类号： C07D471/08

摘要： The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).

摘要翻译： 本发明涉及式（I）化合物，其中R 1a，R 1b，R 1c，R 1d，R 2a，R 2b，R 3，R 4，p，r和如本文所定义，其制备，药物组合物和用作调节剂 11＆bgr-羟基类固醇脱氢酶1（11＆bgr; HSD1）的活性。

3.

发明申请
DERIVATIVES OF UREAS OF PIPERIDINE OR PYRROLIDINE, THEIR PREPARATION AND THEIR THERAPEUTICAL USE 有权
标题翻译：哌啶或吡咯烷酸的制剂及其制剂及其治疗用途的衍生物

公开(公告)号：US20090176775A1

公开(公告)日：2009-07-09

申请号：US12337967

申请日：2008-12-18

申请人： Alain BRAUN , Patrick MOUGENOT , Claudie NAMANE , Eric NICOLAI , Francois PACQUET , Christophe PHILIPPO , Olivier VENIER , Olivier CRESPIN , Cecile PASCAL , Michel ALETRU , Stefan GUSSREGEN

发明人： Alain BRAUN , Patrick MOUGENOT , Claudie NAMANE , Eric NICOLAI , Francois PACQUET , Christophe PHILIPPO , Olivier VENIER , Olivier CRESPIN , Cecile PASCAL , Michel ALETRU , Stefan GUSSREGEN

IPC分类号： A61K31/538 , C07D471/00 , A61K31/438 , C07D215/14 , A61K31/47 , C07D265/36 , C07D241/36 , A61K31/498 , A61P3/00 , A61P9/00 , A61P37/00

CPC分类号： C07D401/14 , C07D401/06 , C07D403/06 , C07D403/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14

摘要： The present invention is related to a compound of formula (I): wherein i, j, n, o, p, q, r, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b and R4 are as defined herein, or an addition salt with an acid thereof, or a hydrate or solvate thereof, its preparation, pharmaceutical composition, and uses for treating a disease in which the enzyme 11β-HSD1 is involved.

摘要翻译： 本发明涉及式（I）化合物：其中i，j，n，o，p，q，r，R1a，R1b，R1c，R1d，R2a，R2b，R2c，R2d，R3a，R3b和R4 或其与酸或其水合物或溶剂合物的加成盐，其制备方法，药物组合物和用于治疗其中涉及酶11beta-HSD1的疾病的用途。

4.

发明申请
UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 有权
标题翻译： TROPANE的尿素衍生物及其制备及其治疗应用

公开(公告)号：US20090170894A1

公开(公告)日：2009-07-02

申请号：US12332547

申请日：2008-12-11

申请人： Michel ALETRU , Alain Jean BRAUN , Claudie NAMANE , Olivier VENIER , Christophe PHILIPPO , Patrick MOUGENOT , Eric NICOLAI , Stefan GUSSREGEN

发明人： Michel ALETRU , Alain Jean BRAUN , Claudie NAMANE , Olivier VENIER , Christophe PHILIPPO , Patrick MOUGENOT , Eric NICOLAI , Stefan GUSSREGEN

IPC分类号： A61K31/46 , C07D401/06 , C07D401/14 , C07D409/14 , C07D405/14 , A61K31/4709 , A61P3/00 , A61P25/00 , A61P9/10 , A61P19/00

CPC分类号： C07D471/08

摘要： The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).

摘要翻译： 本发明涉及式（Ⅰ）化合物，其中R1a，R1b，R1c，R1d，R2a，R2b，R3，R4，p，r和如本文所定义，其制备，药物组合物和用作调节剂 11β-羟基类固醇脱氢酶1型（11betaHSD1）的活性。

5.

发明申请
NOVEL SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF AND USE OF SAME IN THERAPEUTICS 审中-公开
标题翻译：新型替代治疗剂，其制剂及其在治疗中的应用

公开(公告)号：US20100298377A1

公开(公告)日：2010-11-25

申请号：US12636357

申请日：2009-12-11

申请人： Michel ALETRU , Dominique DAMOUR , Patrick MOUGENOT , Frederico NARDI , Patrick NEMECEK , Christophe PHILIPPO , Catherine MONSEAU , Claudie NAMANE

发明人： Michel ALETRU , Dominique DAMOUR , Patrick MOUGENOT , Frederico NARDI , Patrick NEMECEK , Christophe PHILIPPO , Catherine MONSEAU , Claudie NAMANE

IPC分类号： A61K31/4545 , C07D401/10 , A61K31/454 , C07D401/14 , A61P35/00

CPC分类号： C07D401/14 , C07D401/12

摘要： This disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, E, and n1 are as defined in the disclosure, to compositions containing them, to processes for preparing them, and the use thereof.

摘要翻译： 本公开涉及式（I）化合物：其中R 1，R 2，R 3，R 4，E和n 1如本公开所定义，含有它们的组合物，其制备方法及其用途。