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1.发明申请AZOLOARINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICALS CONTAINING THESE COMPOUNDS AND THE USE THEREOF 审中-公开阿拉伯糖衍生物，其生产方法，含有这些化合物的药物及其用途公开(公告)号：US20100240580A1
公开(公告)日：2010-09-23
申请号：US12708179
申请日：2010-02-18
申请人： Gerhard ZOLLER , Marc Dietrich VOSS , Hans MATTER , Andreas HERLING , Christophe Philippo , Claudie NAMANE , Juan-Antonio SANCHEZ-ARIAS
发明人： Gerhard ZOLLER , Marc Dietrich VOSS , Hans MATTER , Andreas HERLING , Christophe Philippo , Claudie NAMANE , Juan-Antonio SANCHEZ-ARIAS
IPC分类号： A61K38/28 , C07D235/18 , A61K31/4184 , A61P3/10 , A61P3/04 , A61P5/50 , A61P25/28 , A61P9/00 , A61P3/06 , A61P25/18 , C07D401/12 , A61K31/4439 , C07D409/12 , C07D417/12 , A61K31/427 , A61K38/27 , A61K31/48 , A61P5/06
CPC分类号： C07D235/18 , C07D401/12 , C07D409/12 , C07D417/12
摘要： The invention relates to azoloarine derivatives of formula I wherein R, A, B, D, Y, X, M and W are as defined herein, and their physiologically tolerated salts.
摘要翻译： 本发明涉及式I的偶氮合成衍生物，其中R，A，B，D，Y，X，M和W如本文所定义，以及它们的生理上耐受的盐。
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![2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS](/abs-image/US/2010/06/10/US20100144594A1/abs.jpg.150x150.jpg)
2.发明申请2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS 有权2-异丙基吡咯并[3,4-C]吡咯并吡喃衍生物及其作为SCD抑制剂的用途公开(公告)号：US20100144594A1
公开(公告)日：2010-06-10
申请号：US12605631
申请日：2009-10-26
IPC分类号： A61K31/427 , C07D487/04 , A61K31/517 , A61K31/4439 , A61K31/501 , A61K38/28 , A61P25/00 , A61P3/00 , A61P9/00 , A61P25/18 , A61P25/28 , A61P3/10
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclic derivatives of formula I wherein R, R1, A, B, D, M, L and n are as defined herein, or their physiologically compatible salts, their pharmaceutical compositions and their uses as SCD1 inhibitors.
摘要翻译： 本发明涉及式I的杂环衍生物，其中R，R 1，A，B，D，M，L和n如本文所定义，或其生理上相容的盐，其药物组合物及其作为SCD1抑制剂的用途。
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3.发明申请SPIROCYCLICALLY SUBSTITUTED 1,3-PROPANE DIOXIDE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 有权螺旋取代的1,3-丙二酮衍生物，其制备方法及其作为药物的用途公开(公告)号：US20120004187A1
公开(公告)日：2012-01-05
申请号：US13176333
申请日：2011-07-05
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K38/16 , A61K31/337 , A61P3/10 , C07D213/64 , C07D305/04 , C07C59/68 , A61K31/44 , A61K31/19
CPC分类号： C07C59/72 , C07D213/64 , C07D213/65 , C07D305/06
摘要： The invention relates to spirocyclically substituted 1,3-propane dioxide derivatives, and to the physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, A and X are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及螺环取代的1,3-丙二醇衍生物及其与生理相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，A和X各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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4.发明申请(CARBOXYLALKYLENEPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF AND USE OF SAME AS A MEDICAMENT 审中-公开（羧甲基烯丙基）苯并噻唑类，其生产方法及其作为药物的用途公开(公告)号：US20130231388A1
公开(公告)日：2013-09-05
申请号：US13864622
申请日：2013-04-17
申请人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
发明人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
IPC分类号： C07C237/04
CPC分类号： C07C237/04 , C07C235/80
摘要： The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（羧基亚烷基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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5.发明申请HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS 有权具有OXO基团的杂环取代的甲氧基衍生物，其制备方法和作为药物的用途公开(公告)号：US20120004165A1
公开(公告)日：2012-01-05
申请号：US13154946
申请日：2011-06-07
申请人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Stefanie KEIL , Elisabeth DEFOSSA , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K38/28 , C07D265/36 , C07D215/227 , C07D277/68 , C07D498/04 , A61K31/404 , A61K31/538 , A61K31/5383 , A61K31/4704 , A61K31/428 , A61K38/27 , A61K31/702 , A61K31/4439 , A61K38/22 , A61K31/445 , A61K31/4985 , A61K31/451 , A61P3/10 , C07D209/34
CPC分类号： C07D209/34 , C07D215/227 , C07D265/36 , C07D277/68 , C07D498/04
摘要： Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicamentsThe invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R10, X, n, B1, B2, B3 and B4 are each defined as specified, and to the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 具有氧代基的杂环取代的甲氧基苯基衍生物，其制备方法及其作为药物的用途本发明涉及具有氧代基的杂环取代的甲氧基苯基衍生物及其生理上相容的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 10，X，n，B 1，B 2，B 3和B 4各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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6.发明申请(CARBOXYLALKYLENEPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF AND USE OF SAME AS A MEDICAMENT 有权（羧甲基烯丙基）苯并噻唑类，其生产方法及其作为药物的用途公开(公告)号：US20100261645A1
公开(公告)日：2010-10-14
申请号：US12724519
申请日：2010-03-16
申请人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
发明人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
IPC分类号： A61K31/196 , C07C235/74 , A61K31/245 , A61K38/28 , A61K31/64 , A61K31/426 , A61K38/27 , A61P3/10 , A61P25/00 , A61P25/28 , A61P25/18
CPC分类号： C07C237/04 , C07C235/80
摘要： The invention relates to (carboxylalkylenephenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（羧基亚烷基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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7.发明申请(CYCLOPROPYLPHENYL)PHENYLOXAMIDES, METHOD FOR THE PRODUCTION THEREOF, AND USE OF SAME AS A MEDICAMENT 有权（环丙基苯基）苯甲酰胺，其生产方法及其作为药物的用途公开(公告)号：US20100261644A1
公开(公告)日：2010-10-14
申请号：US12724517
申请日：2010-03-16
申请人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
发明人： Elisabeth DEFOSSA , Thomas KLABUNDE , Viktoria DIETRICH , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK
IPC分类号： A61K31/196 , C07C235/74 , A61K38/28 , A61K31/64 , A61K31/426 , A61K38/27 , A61P3/10 , A61P25/28 , A61P25/00
CPC分类号： C07C233/56 , C07C233/88
摘要： The invention relates to (cyclopropylphenyl)phenyloxamides and their physiologically tolerated salts, and their use as a medicament.
摘要翻译： 本发明涉及（环丙基苯基）苯氧基酰胺及其生理上耐受的盐，以及它们作为药物的用途。
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8.发明申请USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME 有权使用替代吡咯烷酮衍生物治疗代谢综合征公开(公告)号：US20100144862A1
公开(公告)日：2010-06-10
申请号：US12504198
申请日：2009-07-16
申请人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
发明人： Harm BRUMMERHOP , Siegfried STENGELIN , Hubert HEUER , Susanne KILP , Andreas HERLING , Thomas KLABUNDE , Dieter KADEREIT , Matthias URMANN
IPC分类号： A61K31/351 , C07D309/40 , C07D309/38 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P3/06 , A61P1/18 , A61P35/00 , A61P25/28 , A61P25/16 , A61P17/10 , A61P17/00 , A61P11/06
CPC分类号： A61K31/351
摘要： The invention relates to the use of substituted pyranone acid derivatives and of their physiologically acceptable salts for producing medicaments for treating the metabolic syndrome.
摘要翻译： 本发明涉及取代的吡喃酮酸衍生物及其生理学上可接受的盐用于制备用于治疗代谢综合征的药物的用途。
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![3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT](/abs-image/US/2013/07/04/US20130172248A1/abs.jpg.150x150.jpg)
9.发明申请3-[4-(PHENYLAMINOOXALYLAMINO)PHENYL]HEX-4-YNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT 审中-公开3- [4-（苯甲酰氨基氨基）苯基]十六烷基-4-氨基酸，其制备方法和用作药物公开(公告)号：US20130172248A1
公开(公告)日：2013-07-04
申请号：US13734413
申请日：2013-01-04
申请人： Elisabeth DEFOSSA , Viktoria DIETRICH , Thomas KLABUNDE , Stefanie KEIL , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK , Simon GESSLER , Angela DUDDA , Guenter BILLEN , Thomas OLPP , Joerg RIEKE-ZAPP
发明人： Elisabeth DEFOSSA , Viktoria DIETRICH , Thomas KLABUNDE , Stefanie KEIL , Siegfried STENGELIN , Guido HASCHKE , Andreas HERLING , Johanna KUHLMANN-GOTTKE , Stefan BARTOSCHEK , Simon GESSLER , Angela DUDDA , Guenter BILLEN , Thomas OLPP , Joerg RIEKE-ZAPP
IPC分类号： C07C233/56 , A61K38/28 , C07C231/02 , C07C229/42 , A61K31/196 , A61K45/06
CPC分类号： C07C233/56 , A61K31/196 , A61K38/28 , A61K45/06 , C07C229/42 , C07C231/02 , A61K2300/00
摘要： The invention relates to 3-[4-(phenylaminooxalylamino)phenyl]hex-4-ynoic acids, and to physiologically compatible salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3 and R4 are each defined as specified, and to physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及3- [4-（苯基氨基草酰氨基）苯基]己-4-炔酸，以及其生理上相容的盐。 本发明涉及式Ⅰ化合物，其中R 1，R 2，R 3和R 4各自定义和其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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10.发明申请(2-ARYLOXYACETYLAMINO) PHENYLPROPIONIC ACID DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS 有权（2-ARYLOXYACETYLAMINO）苯丙酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20120004167A1
公开(公告)日：2012-01-05
申请号：US13176503
申请日：2011-07-05
申请人： Elisabeth DEFOSSA , Stefanie KEIL , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
发明人： Elisabeth DEFOSSA , Stefanie KEIL , Viktoria DIETRICH , Siegfried STENGELIN , Andreas HERLING , Guido HASCHKE , Thomas KLABUNDE
IPC分类号： A61K31/197 , C07C255/43 , A61P3/10 , A61K38/28 , A61K38/27 , A61K31/702 , A61K31/40 , A61K31/403 , A61K31/472 , A61K31/4439 , A61K38/17 , A61K31/4985 , A61K31/451 , A61P3/08 , C07C229/42
CPC分类号： C07C235/24 , C07C255/44
摘要： The invention relates to substituted (2-aryloxyacetylamino)phenylpropionic acid derivatives, and to the physiologically acceptable salts thereof.The invention relates to compounds of the formula I in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and A are each defined as specified, and the physiologically compatible salts thereof. The compounds are suitable, for example, for treatment of diabetes.
摘要翻译： 本发明涉及取代的（2-芳氧基乙酰基氨基）苯基丙酸衍生物及其生理上可接受的盐。 本发明涉及其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9和A各自如上所定义的式Ⅰ化合物及其生理上相容的盐。 该化合物适用于例如治疗糖尿病。
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