公开(公告)号：US06428734B1

公开(公告)日：2002-08-06

申请号：US09505433

申请日：2000-02-16

申请人： Michel Vandevelde ,  Bernard Forment

发明人： Michel Vandevelde ,  Bernard Forment

IPC分类号： B29C4527

CPC分类号： B29C45/33 ,  B29C45/0046 ,  B29C45/26 ,  B29L2031/7134 ,  B65D1/22 ,  Y10S425/058

摘要： The invention relates to a process for manufacturing injection moulded objects of thermoplastic material by injecting molten thermoplastic material into a mould from at least two distinct injection points whereas the flows of molten material from each injection point each fill part of the mould and flow together to fill the entire mould while still in molten state, wherein objects having a size of more than 80 cm along each of its three dimensional axes are produced by providing at least two distinct injection points at opposite sides of the mould. The invention also relates to injection moulding equipment for the manufacture of moulded objects of thermoplastic material, comprising at least two distinct injection points provided at opposite sides of a single mould assembly. The invention further also relates to three dimensional moulded objects of thermoplastic material having a size of more than 80 cm along each of its three dimensional axes. The mould assembly has side walls that move sideways when opening the mould to facilitate demoulding of the moulded object.

摘要翻译： 本发明涉及通过将熔融热塑性材料从至少两个不同的注入点注入模具中来制造热塑性材料的注射成型物体的方法，而来自每个注射点的熔融材料的流动各自填充模具的一部分并一起流动以填充 整个模具仍然处于熔融状态，其中通过在模具的相对侧提供至少两个不同的注入点来制造具有大于其三维轴线的尺寸大于80cm的物体。 本发明还涉及用于制造热塑性材料的模制物体的注塑设备，其包括设置在单个模具组件的相对侧上的至少两个不同的注入点。 本发明还涉及热塑性材料的三维模制物体，其尺寸大于其三维轴上的80cm。 模具组件具有在打开模具时侧向移动以便于模制物体脱模的侧壁。

公开(公告)号：US6103175A

公开(公告)日：2000-08-15

申请号：US782257

申请日：1997-01-14

申请人： Michel Vandevelde

发明人： Michel Vandevelde

IPC分类号： B29C45/00 ,  B29C45/26 ,  B29C45/33 ,  B65D1/22 ,  B29B7/00

CPC分类号： B29C45/26 ,  B29C45/0046 ,  B29C45/33 ,  B65D1/22 ,  B29C2045/0027 ,  B29L2031/7126 ,  B29L2031/7134 ,  Y10S264/83

摘要： The invention relates to a process for manufacturing injection moulded objects of thermoplastic material by injecting molten thermoplastic material into a mould from at least two distinct injection points whereas the flows of molten material from each injection point each fill part of the mould and flow together to fill the entire mould while still in molten state, wherein objects having a size of more than 80 cm along each of its three dimensional axes are produced by providing at least two distinct injection points at opposite sides of the mould. The invention also relates to injection moulding equipment for the manufacture of moulded objects of thermoplastic material, comprising at least two distinct injection points provided at opposite sides of a single mould assembly. The invention further also relates to threedimensional moulded objects of thermoplastic material having a size of more than 80 cm along each of its threedimensional axes.

摘要翻译： 本发明涉及通过将熔融热塑性材料从至少两个不同的注入点注入模具中来制造热塑性材料的注射成型物体的方法，而来自每个注射点的熔融材料的流动各自填充模具的一部分并一起流动以填充 整个模具仍然处于熔融状态，其中通过在模具的相对侧提供至少两个不同的注入点来制造具有大于其三维轴线的尺寸大于80cm的物体。 本发明还涉及用于制造热塑性材料的模制物体的注塑设备，其包括设置在单个模具组件的相对侧上的至少两个不同的注入点。 本发明还涉及热塑性材料的三维模制物体，其尺寸大于其三维轴上的80cm。

公开(公告)号：US06407081B1

公开(公告)日：2002-06-18

申请号：US09555258

申请日：2000-10-13

申请人： Michel Goldman ,  Hélène Margery ,  Patrick Adelin Oscar Robberecht ,  Jean Pierre Robert Tassignon ,  Michel Vandevelde

发明人： Michel Goldman ,  Hélène Margery ,  Patrick Adelin Oscar Robberecht ,  Jean Pierre Robert Tassignon ,  Michel Vandevelde

IPC分类号： A61K31655

CPC分类号： A61K31/655

摘要： The invention concerns a method for inhibiting cytokine production by cells, in particular animal or human cells, and their secretion, which consists in applying on said cells at least an azo compound derivatives corresponding to formula (I), in which A represents a carboxyl or a group (a); B represents a carboxyl or a group (b); R1, R2, R3 and R4=H, Hal, OH or a hydrocarbon radical, R1 and R2 as well as R3 and R4 capable of being a heterocyclic ring; X1 and X2=O or NR5, where R5=H, Hal, a hydrocarbon radical or a nitro group.

摘要翻译： 本发明涉及一种抑制细胞特别是动物或人类细胞及其分泌物的细胞因子产生的方法，其包括在所述细胞上施用至少一种对应于式（I）的偶氮化合物衍生物，其中A代表羧基或 一组（a）; B表示羧基或基团（b）; R1，R2，R3和R4 = H，Hal，OH或烃基，R1和R2以及能够成为杂环的R3和R4; X1和X2 = O或NR5，其中R5 = H，Hal，烃基或硝基。

公开(公告)号：US06271218B1

公开(公告)日：2001-08-07

申请号：US09254652

申请日：1999-03-30

申请人： Michel Vandevelde ,  Hélène Margery

发明人： Michel Vandevelde ,  Hélène Margery

IPC分类号： A61K31655

CPC分类号： A61K31/655

摘要： Process for inhibiting deoxyribonucleotide triphosphate biosynthesis by cells, comprising application onto these cells of at least one of the azo derivatives of the formula (I), in which R1, R2, R3 and R4=H, Hal, aliphatic or aromatic hydrocarbon or a nitro group, R1 and R2 as well as R3 and R4 being capable of forming a heterocyclic ring with the N adjacent thereto, X1 and X2=0 or NR5, where R5=H, Hal, aliphatic or aromatic hydrocarbon, or a nitro group, and the use of these derivatives for the production of medicines to be administered in conditions which require abnormal production of DNA from the cells

摘要翻译： 用于抑制细胞的脱氧核糖核苷三磷酸生物合成的方法，其包括将至少一种式（I）的偶氮衍生物，其中R 1，R 2，R 3和R 4 = H，Hal，脂族或芳族烃或硝基 基团，R 1和R 2以及R 3和R 4能够与其相邻的N形成杂环，X 1和X 2 = 0或NR 5，其中R 5 = H，Hal，脂族或芳族烃或硝基，以及 这些衍生物用于生产需要在细胞中异常产生DNA的条件下施用的衍生物

公开(公告)号：US5585367A

公开(公告)日：1996-12-17

申请号：US406143

申请日：1995-03-20

申请人： Michel Vandevelde ,  H el ene Margery

发明人： Michel Vandevelde ,  H el ene Margery

IPC分类号： A61K31/655

CPC分类号： A61K31/655

摘要： Compositions useful in methods of treating humans and animals infected with viruses of the retrovirus group contain azoic compounds of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are indentical or different and each represents an atom of hydrogen or an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms, R.sup.1 and R.sup.2 may be bonded together to form a heterocyclic ring with their adjacent nitrogen atom, and R.sup.3 and R.sup.4 may be bonded together to form a heterocyclic ring with their adjacent nitrogen atom; X.sup.1 and X.sup.2 are indentical or different and each represents an oxygen atom or an NR.sup.5 group, wherein R.sup.5 is a hydrogen atom, an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms, or a nitro group; and wherein when two NR.sup.5 groups are simultaneously present each R.sup.5 may be indentical to or different from the other.

摘要翻译： 用于治疗感染有逆转录病毒病毒的病毒的人和动物的方法中的组合物含有通式为“IMAGE”的有机化合物，其中R1，R2，R3和R4是不同的或不同的，并且各自表示氢或脂族或芳族的原子 包含1至6个碳原子的烃基可以与其相邻的氮原子键合在一起形成杂环，并且R 3和R 4可以键合在一起以与其相邻的氮原子形成杂环; X 1和X 2是不同的或不同的，并且各自表示氧原子或NR 5基团，其中R 5是氢原子，含有1至6个碳原子的脂族或芳族烃基或硝基; 并且其中当两个NR 5基团同时存在时，每个R 5可以与另一个不相同或不同。

公开(公告)号：US20070110815A1

公开(公告)日：2007-05-17

申请号：US11586723

申请日：2006-10-26

申请人： Michel Vandevelde ,  Helene Margery

发明人： Michel Vandevelde ,  Helene Margery

IPC分类号： A61K9/14 ,  A61K31/655

CPC分类号： A61K9/14 ,  A61K9/0034 ,  A61K9/0095 ,  A61K9/4858 ,  A61K31/655

摘要： Azodicarbonamide (ADA) in the form of a micronised dry powder, said powder having a granulometric distribution of particles wherein the particles of the powder have a mean diameter (d50) equal to or less than 2 μm and a 90% diameter (d90) equal to or less than 4 μm.

摘要翻译： 微粉化干粉形式的偶氮二甲酰胺（ADA），所述粉末具有颗粒的粒度分布，其中粉末的颗粒具有等于或小于2μm的平均直径（d≤50）;和 等于或小于4μm的90％直径（d <90％）。

公开(公告)号：US5399555A

公开(公告)日：1995-03-21

申请号：US947090

申请日：1992-09-17

申请人： Michel Vandevelde ,  Helene Margery

发明人： Michel Vandevelde ,  Helene Margery

IPC分类号： A61K8/40 ,  A61K31/655 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61Q11/00 ,  C07C281/20 ,  B61K31/655

CPC分类号： A61K31/655

摘要： Compositions useful in methods of disinfecting contain azoic compounds of the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and each represents an atom of hydrogen or an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms; X.sup.1 and X.sup.2 are identical or different and each represents an oxygen atom or an NR.sup.5 group, wherein R.sup.5 is a hydrogen atom, an aliphatic or aromatic hydrocarbon radical comprising from 1 to 6 carbon atoms, or a nitro group; and wherein when two NR.sup.5 groups are simultaneously present each R.sup.5 may be identical to or different from the other. Compositions containing the azoic compounds in a liquid medium at concentrations of from 35 .mu.gr/ml to 2 mgr/ml are sufficient to impede replication and proliferation of viruses of the retrovirus group yet they are insufficiently toxic to destroy sound human or animal cells which come in contact with the compositions. Methods of disinfecting using the compositions are also provided.

摘要翻译： 用于消毒方法的组合物含有通式为“IMAGE”的偶氮化合物，其中R 1，R 2，R 3和R 4相同或不同，并且各自表示氢原子或含有1至6个碳原子的脂族或芳族烃基; X 1和X 2相同或不同，各自表示氧原子或NR 5基团，其中R 5是氢原子，含有1至6个碳原子的脂族或芳族烃基或硝基; 并且其中当两个NR 5基团同时存在时，每个R 5可以与另一个相同或不同。 在液体培养基中含有浓度为35μg/ ml至2mgr / ml的偶氮化合物的组合物足以阻止逆转录病毒组病毒的复制和增殖，但它们毒性不足以破坏出现的健康的人或动物细胞 与组合物接触。 还提供了使用组合物消毒的方法。