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公开(公告)号：US5350800A
公开(公告)日：1994-09-27
申请号：US5711
申请日：1993-01-19
CPC分类号： A61L33/0029 , A61L33/0041 , A61L33/0047 , A61L33/0088
摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.
摘要翻译： 通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法 到胺化的固体表面，然后选择性地将羧基还原成生物分子。 羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。 该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。
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公开(公告)号：US06746481B1
公开(公告)日：2004-06-08
申请号：US09340440
申请日：1999-06-28
IPC分类号： A61F206
CPC分类号： A61M25/0045 , A61L31/06 , A61L31/16 , A61L2300/214 , A61M2025/0056 , C08L77/00
摘要： An implantable device for reducing restenosis includes a structure including a polyamino acid component, wherein the polyamino acid component can be in the form of a coating or a film on the structure or it can be an integral part of the structure.
摘要翻译： 用于减少再狭窄的可植入装置包括包括聚氨基酸组分的结构，其中聚氨基酸组分可以是结构上的涂层或膜的形式，或者其可以是结构的组成部分。
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公开(公告)号：US5767108A
公开(公告)日：1998-06-16
申请号：US518147
申请日：1995-08-22
申请人： Patrick Cahalan , Theo Lindhout , Benedict Fouache , Michel Verhoeven , Linda Cahalan , Marc Hendriks , Ron Blezer
发明人： Patrick Cahalan , Theo Lindhout , Benedict Fouache , Michel Verhoeven , Linda Cahalan , Marc Hendriks , Ron Blezer
CPC分类号： A61L33/0029 , A61L33/128 , Y10S514/802 , Y10S514/822
摘要： A method of treating a patient with a medical device having immobilized heparin on a blood-contacting surface in which the covalently attached heparinized surface is provided with an adsorbed protein which may be activated by the immobilized heparin to block the coagulation of fibrinogen. Antithrombin III is the preferred adsorbed protein. The adsorbed protein is maintained on the immobilized heparin surface until the medical device is placed into contact with the patient's blood. When in contact with the patient's blood, the adsorbed protein will prevent initial thrombin formation at the biomaterial-blood interface. The preadsorption of ATIII is accomplished under conditions advantageous to maximum heparin/ATIII binding. When the preadsorbed surface comes in contact with whole blood, the maximum advantage of prophlactic properties of ATIII/heparin are obtained.
摘要翻译： 在患有共价连接的肝素化表面的血液接触表面上用具有固定化肝素的医疗装置治疗患者的方法，所述吸附蛋白可被固定化肝素激活以阻断纤维蛋白原的凝结。 抗凝血酶III是优选的吸附蛋白。 吸附的蛋白质保持在固定化的肝素表面上，直到医疗装置与患者的血液接触。 当与患者的血液接触时，吸附的蛋白质将阻止在生物材料 - 血液界面处的初始凝血酶形成。 ATIII的预吸附在有利于最大肝素/ ATIII结合的条件下完成。 当预吸附的表面与全血接触时，获得了ATIII /肝素的前体特性的最大优点。
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公开(公告)号：US6024918A
公开(公告)日：2000-02-15
申请号：US41497
申请日：1998-03-13
申请人： Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Edouard Koulik , Mirian Gillissen
发明人： Marc Hendriks , Michel Verhoeven , Patrick Cahalan , Linda Cahalan , Edouard Koulik , Mirian Gillissen
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L31/16 , A61L33/0029 , A61L2300/236 , A61L2300/42 , A61L2300/606 , A61L2400/18
摘要： A method for making a medical device having a biomolecule immobilized on a substrate surface is provided. The method includes coating the substrate surface with an amino-functional polysiloxane; and contacting the amino-functional polysiloxane coated surface with a biomolecule under conditions effective to immobilize the biomolecule.
摘要翻译： 提供一种制造具有固定在基板表面上的生物分子的医疗装置的方法。 该方法包括用氨基官能的聚硅氧烷涂覆基材表面; 并在有效固定生物分子的条件下使氨基官能的聚硅氧烷涂覆的表面与生物分子接触。
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5.发明授权Method for attachment of biomolecules to surfaces through amine-functional groups 失效通过胺官能团将生物分子附着到表面的方法公开(公告)号：US06303179B1
公开(公告)日：2001-10-16
申请号：US09245834
申请日：1999-02-08
IPC分类号： A61L5103
CPC分类号： A61L33/0029
摘要： A method of modifying the surface characteristics of a substrate having a surface with an amide-functional polymer thereon. The method involves contacting the amide-functional polymer with a source of hydroxide ions and a source of hypohalite ions at a temperature of at least about 20° C. for a time effective to convert at least a portion of the amide-functional groups to amine-functional groups to form a substrate surface comprising an amine-functional polymer, wherein the hydroxide ions are present in a molar excess relative to the hypohalite ions and at a concentration of no more than about 0.1 M, based on the total volume of the reaction mixture. A biomolecule is attached to the resultant amine-functional polymer.
摘要翻译： 一种改变其上具有酰胺官能聚合物的表面的基材的表面特性的方法。 该方法包括在至少约20℃的温度下将酰胺官能聚合物与氢氧根离子源和次卤酸盐离子源接触，将有效的至少一部分酰胺官能团转化成胺 功能基团以形成包含胺官能聚合物的底物表面，其中氢氧根离子相对于次卤酸盐离子以摩尔过量存在，并且以不超过约0.1M的浓度，基于反应的总体积 混合物。 将生物分子连接到所得的胺官能聚合物上。
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6.发明申请Stents and methods for preparing stents from wires having hydrogel coating layers thereon 失效用于从其上具有水凝胶涂层的线制备支架的支架和方法公开(公告)号：US20050251250A1
公开(公告)日：2005-11-10
申请号：US11181495
申请日：2005-07-13
CPC分类号： A61L31/145 , A61F2/86 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.
摘要翻译： 公开了其上具有水凝胶涂层的可径向扩张的支架，以及制备这种支架的方法。 所述方法包括用包含溶剂和在溶剂中的水溶性聚合物的溶液涂覆线材，蒸发溶剂以在线材上提供聚合物涂层，并交联聚合物涂层以在线材上提供水凝胶涂层。 涂覆的线可以制成支架，其优选地具有基本均匀的具有低表面粗糙度的涂层。 优选地，涂层具有亲水性质并提供生物相容性表面。 涂层还可以提供将生物活性剂递送到体内。
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公开(公告)号：US6143354A
公开(公告)日：2000-11-07
申请号：US245840
申请日：1999-02-08
CPC分类号： A61L33/0011 , A61L27/34
摘要： A method of modifying the surface characteristics of a substrate, particularly a polymeric material. The method involves grafting ethylenically unsaturated monomers and attaching biomolecules, such as heparin, to the surface of the substrate, such as a polymeric material, in one step using an oxidizing metal, such as ceric ions.
摘要翻译： 改进基材，特别是聚合物材料的表面特性的方法。 该方法包括使用氧化金属如铈离子在一个步骤中接枝烯键式不饱和单体并将生物分子如肝素附着到基底表面，例如聚合物材料。
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公开(公告)号：US6166184A
公开(公告)日：2000-12-26
申请号：US912778
申请日：1997-08-18
申请人： Marc Hendriks , Verhoeven Michel , Patrick Cahalan , Mark W. Torrianni , Linda Cahalan , Benedicte Fouache
发明人： Marc Hendriks , Verhoeven Michel , Patrick Cahalan , Mark W. Torrianni , Linda Cahalan , Benedicte Fouache
CPC分类号： A61L27/3687 , C08H1/06
摘要： Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.
摘要翻译： 提供用于制造具有胶原胺基和胶原羧基的胶原基材料制成生物假体装置的方法。 所述方法包括用封闭剂封闭至少一部分胶原胺基团，在封闭至少一部分胶原胺基团以形成活化的羧基之后激活至少一部分胶原羧基，并使活化的胶原 羧基与多官能间隔基交联胶原基材料。
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公开(公告)号：US5702818A
公开(公告)日：1997-12-30
申请号：US430001
申请日：1995-04-27
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkylimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基亚胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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公开(公告)号：US5415938A
公开(公告)日：1995-05-16
申请号：US193964
申请日：1994-02-09
CPC分类号： A61L33/0041 , A61L33/0005 , A61L33/0029 , Y10T428/31 , Y10T428/31504 , Y10T428/31562 , Y10T428/31721 , Y10T428/31946
摘要： An improved spacer material for improving the biocompatibility of a biomaterial and a method for making it in which a polyalkylimine is covalently attached to an aminated substrate and combined with a crosslinking agent which is at least difunctional in aldehyde groups. The polyalkylimine can be, for example, polyethyleneimine and the crosslinking agent can be, for example, glutaraldehyde. Preferably, the crosslinking agent is applied in dilute solution and at a pH suitable to accomplish light crosslinking of the polyalkyaimine and also provide aldehyde linkages at the interface between the biomolecule and the spacer.
摘要翻译： 用于改善生物材料的生物相容性的改进的间隔物材料及其制备方法，其中聚烷基亚胺共价连接到胺化底物上并与醛基中至少具有双官能团的交联剂组合。 聚烷基亚胺可以是例如聚乙烯亚胺，交联剂可以是例如戊二醛。 优选地，交联剂以稀溶液和适于实现聚烷基亚胺的轻交联的pH施加，并且还在生物分子和间隔物之间的界面处提供醛键。
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