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22 条记录 (耗时 0.031 秒)

    Method for improving the biocompatibility of solid surfaces
    1.
    发明授权
    Method for improving the biocompatibility of solid surfaces 失效
    提高固体表面生物相容性的方法

    公开(公告)号：US5350800A

    公开(公告)日：1994-09-27

    申请号：US5711

    申请日：1993-01-19

    申请人： Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Marc Hendriks ,  Benedicte Foache

    发明人： Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Marc Hendriks ,  Benedicte Foache

    IPC分类号： A61L27/00 ,  A61L29/00 ,  A61L33/00 ,  A61L33/10 ,  A61F2/54 ,  A61F2/02 ,  A61K9/22

    CPC分类号： A61L33/0029 ,  A61L33/0041 ,  A61L33/0047 ,  A61L33/0088

    摘要： A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.

    摘要翻译： 通过使生物分子与碳二亚胺反应以使生物分子的羧基活化，使碳二亚胺活化的生物分子与固体表面反应，使生物分子共价结合，将具有多个羧基的生物分子连接到胺化的固体表面上的方法 到胺化的固体表面，然后选择性地将羧基还原成生物分子。 羧基的选择性还原可以通过温和的水解进行，并恢复生物分子的功能。 该方法是“选择性的”，因为生物分子和胺化的固体表面之间的键保持完整。

    Method for making improved heparinized biomaterials
    3.
    发明授权
    Method for making improved heparinized biomaterials 失效
    改善肝素化生物材料的方法

    公开(公告)号：US5767108A

    公开(公告)日：1998-06-16

    申请号：US518147

    申请日：1995-08-22

    申请人： Patrick Cahalan ,  Theo Lindhout ,  Benedict Fouache ,  Michel Verhoeven ,  Linda Cahalan ,  Marc Hendriks ,  Ron Blezer

    发明人： Patrick Cahalan ,  Theo Lindhout ,  Benedict Fouache ,  Michel Verhoeven ,  Linda Cahalan ,  Marc Hendriks ,  Ron Blezer

    IPC分类号： A61L33/00 ,  A61L33/12 ,  A61K31/70

    CPC分类号： A61L33/0029 ,  A61L33/128 ,  Y10S514/802 ,  Y10S514/822

    摘要： A method of treating a patient with a medical device having immobilized heparin on a blood-contacting surface in which the covalently attached heparinized surface is provided with an adsorbed protein which may be activated by the immobilized heparin to block the coagulation of fibrinogen. Antithrombin III is the preferred adsorbed protein. The adsorbed protein is maintained on the immobilized heparin surface until the medical device is placed into contact with the patient's blood. When in contact with the patient's blood, the adsorbed protein will prevent initial thrombin formation at the biomaterial-blood interface. The preadsorption of ATIII is accomplished under conditions advantageous to maximum heparin/ATIII binding. When the preadsorbed surface comes in contact with whole blood, the maximum advantage of prophlactic properties of ATIII/heparin are obtained.

    摘要翻译： 在患有共价连接的肝素化表面的血液接触表面上用具有固定化肝素的医疗装置治疗患者的方法，所述吸附蛋白可被固定化肝素激活以阻断纤维蛋白原的凝结。 抗凝血酶III是优选的吸附蛋白。 吸附的蛋白质保持在固定化的肝素表面上，直到医疗装置与患者的血液接触。 当与患者的血液接触时，吸附的蛋白质将阻止在生物材料 - 血液界面处的初始凝血酶形成。 ATIII的预吸附在有利于最大肝素/ ATIII结合的条件下完成。 当预吸附的表面与全血接触时，获得了ATIII /肝素的前体特性的最大优点。

    Method for attachment of biomolecules to surfaces through amine-functional groups
    5.
    发明授权
    Method for attachment of biomolecules to surfaces through amine-functional groups 失效
    通过胺官能团将生物分子附着到表面的方法

    公开(公告)号：US06303179B1

    公开(公告)日：2001-10-16

    申请号：US09245834

    申请日：1999-02-08

    申请人： Edouard Koulik ,  Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Judith Vincent

    发明人： Edouard Koulik ,  Michel Verhoeven ,  Patrick Cahalan ,  Linda Cahalan ,  Judith Vincent

    IPC分类号： A61L5103

    CPC分类号： A61L33/0029

    摘要： A method of modifying the surface characteristics of a substrate having a surface with an amide-functional polymer thereon. The method involves contacting the amide-functional polymer with a source of hydroxide ions and a source of hypohalite ions at a temperature of at least about 20° C. for a time effective to convert at least a portion of the amide-functional groups to amine-functional groups to form a substrate surface comprising an amine-functional polymer, wherein the hydroxide ions are present in a molar excess relative to the hypohalite ions and at a concentration of no more than about 0.1 M, based on the total volume of the reaction mixture. A biomolecule is attached to the resultant amine-functional polymer.

    摘要翻译： 一种改变其上具有酰胺官能聚合物的表面的基材的表面特性的方法。 该方法包括在至少约20℃的温度下将酰胺官能聚合物与氢氧根离子源和次卤酸盐离子源接触，将有效的至少一部分酰胺官能团转化成胺 功能基团以形成包含胺官能聚合物的底物表面，其中氢氧根离子相对于次卤酸盐离子以摩尔过量存在，并且以不超过约0.1M的浓度，基于反应的总体积 混合物。 将生物分子连接到所得的胺官能聚合物上。

    Stents and methods for preparing stents from wires having hydrogel coating layers thereon
    6.
    发明申请
    Stents and methods for preparing stents from wires having hydrogel coating layers thereon 失效
    用于从其上具有水凝胶涂层的线制备支架的支架和方法

    公开(公告)号：US20050251250A1

    公开(公告)日：2005-11-10

    申请号：US11181495

    申请日：2005-07-13

    申请人： Michel Verhoeven ,  Linda Cahalan ,  Patrick Cahalan ,  Vincent Larik

    发明人： Michel Verhoeven ,  Linda Cahalan ,  Patrick Cahalan ,  Vincent Larik

    IPC分类号： A61F2/86 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/06

    CPC分类号： A61L31/145 ,  A61F2/86 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/606

    摘要： Radially expandable stents having hydrogel coating layers thereon, and methods of preparing such stents are disclosed. The methods include coating a wire with a solution that includes a solvent and a water soluble polymer in the solvent, evaporating the solvent to provide a polymeric coating on the wire, and crosslinking the polymeric coating to provide a hydrogel coating layer on the wire. The coated wire can be fabricated into stents, which preferably have substantially uniform coatings with low surface roughness. Preferably the coatings have hydrophilic properties and provide a biocompatible surface. The coatings may also provide for the delivery of biologically active agents into the body.

    摘要翻译： 公开了其上具有水凝胶涂层的可径向扩张的支架，以及制备这种支架的方法。 所述方法包括用包含溶剂和在溶剂中的水溶性聚合物的溶液涂覆线材，蒸发溶剂以在线材上提供聚合物涂层，并交联聚合物涂层以在线材上提供水凝胶涂层。 涂覆的线可以制成支架，其优选地具有基本均匀的具有低表面粗糙度的涂层。 优选地，涂层具有亲水性质并提供生物相容性表面。 涂层还可以提供将生物活性剂递送到体内。

    PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE
    10.
    发明申请
    PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE 有权
    制备用生物分子涂覆的基材的方法

    公开(公告)号：US20080241349A1

    公开(公告)日：2008-10-02

    申请号：US12061212

    申请日：2008-04-02

    申请人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    发明人： Patrick Cahalan ,  Linda Cahalan ,  Greg Johnson ,  Mark Gartner

    IPC分类号： B05D3/04

    CPC分类号： A61L31/10 ,  A61M1/1698 ,  C08L83/04

    摘要： Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.

    摘要翻译： 提供了制备涂覆有生物分子的底物的方法，包括：a）提供底物; b）用聚硅氧烷涂覆基材，通常通过将基材暴露于含有硅氧烷官能团的反应性气体和等离子体能量，以在基材上产生等离子体沉积的聚硅氧烷表面; c）使聚硅氧烷表面具有氨基功能; 和d）在有效地将生物分子附着到底物的条件下，使氨基官能聚硅氧烷表面与生物分子接触。 涂覆的基底可以是与使用该方法未用生物分子涂覆的基本相同的医疗装置相比，其表现出与血液或血液成分接触时保持透气性的能力的医疗装置。