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公开(公告)号:US09625456B2
公开(公告)日:2017-04-18
申请号:US13381209
申请日:2010-07-02
申请人: Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
发明人: Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
CPC分类号: A61K51/1244 , A61K9/5115 , A61K9/5146 , A61K9/5169 , A61K49/0019 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/0093 , A61K51/08 , A61K51/082 , A61K51/086 , A61K51/1255 , B82Y5/00 , B82Y15/00 , G01N33/54346 , G01N33/552 , G01N33/574 , G01N33/582 , G01N33/587 , G01N33/60 , Y10S977/773 , Y10S977/927
摘要: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.
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公开(公告)号:US20130039848A1
公开(公告)日:2013-02-14
申请号:US13381209
申请日:2010-07-02
申请人: Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
发明人: Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
IPC分类号: A61K49/00 , A61K49/06 , A61K49/04 , A61K9/14 , A61K39/395 , A61K31/7088 , A61K48/00 , A61K31/56 , A61K31/713 , A61K31/7105 , G01N21/64 , A61P35/00 , A61P31/04 , A61P31/00 , A61P39/06 , A61P37/06 , A61P7/02 , A61P9/08 , A61P29/00 , A61K51/12 , B82Y5/00 , B82Y15/00
CPC分类号: A61K51/1244 , A61K9/5115 , A61K9/5146 , A61K9/5169 , A61K49/0019 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/0093 , A61K51/08 , A61K51/082 , A61K51/086 , A61K51/1255 , B82Y5/00 , B82Y15/00 , G01N33/54346 , G01N33/552 , G01N33/574 , G01N33/582 , G01N33/587 , G01N33/60 , Y10S977/773 , Y10S977/927
摘要: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.
摘要翻译: 本发明提供一种荧光二氧化硅基纳米颗粒,其允许精确检测,表征,监测和治疗诸如癌症的疾病。纳米颗粒具有位于纳米颗粒内的荧光化合物,并且具有比游离荧光素更高的亮度和荧光量子产率 化合物为了促进纳米颗粒的有效的尿液排泄,可以用有机聚合物如聚乙二醇(PEG)包被)(PEG)小粒径的纳米颗粒,二氧化硅基底和有机聚合物涂层在施用时使纳米颗粒的毒性最小化 在体内纳米颗粒还可以与能够结合与特定细胞类型相关的细胞成分的配体缀合,例如肿瘤标记物A治疗剂可以连接到纳米颗粒放射性核素/放射性金属或顺磁性离子可以与 纳米颗粒以允许纳米颗粒可以通过各种i检测 搜索技巧
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