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公开(公告)号：US20070140972A1
公开(公告)日：2007-06-21
申请号：US10576086
申请日：2004-10-15
申请人： Ying Zhu , Heli Valtanen , Sami Kaukinen , Oula Penate Medina , IIkka Simpura
发明人： Ying Zhu , Heli Valtanen , Sami Kaukinen , Oula Penate Medina , IIkka Simpura
CPC分类号： C07K7/06 , A61K38/12 , A61K47/60 , A61K47/62 , A61K47/6911 , A61K51/08 , A61K51/088 , C07K7/08 , C07K14/81
摘要： The present invention relates to targeted cancer therapy and tumour imaging, and concerns specifically new derivatives of small matrix metalloproteinase inhibitor peptides. These new derivates are the hydrophilic peptides GRENYHGCTTHWGFTLC and derivates thereof. These peptides have an increased solubility and may be used in the preparation of targeting compositions together with suitable linker molecules such as PEG. Such targeting compositions are useful in therapeutics and imaging liposome compositions for cancer treatment and diagnostics.
摘要翻译： 本发明涉及靶向癌症治疗和肿瘤成像，特别涉及小基质金属蛋白酶抑制剂肽的新衍生物。 这些新衍生物是亲水肽GRENYHGCTTHWGFTLC及其衍生物。 这些肽具有增加的溶解性，并可用于制备靶向组合物以及合适的连接分子如PEG。 这样的靶向组合物可用于治疗和成像用于癌症治疗和诊断的脂质体组合物。
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公开(公告)号：US09625456B2
公开(公告)日：2017-04-18
申请号：US13381209
申请日：2010-07-02
申请人： Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
发明人： Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
CPC分类号： A61K51/1244 , A61K9/5115 , A61K9/5146 , A61K9/5169 , A61K49/0019 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/0093 , A61K51/08 , A61K51/082 , A61K51/086 , A61K51/1255 , B82Y5/00 , B82Y15/00 , G01N33/54346 , G01N33/552 , G01N33/574 , G01N33/582 , G01N33/587 , G01N33/60 , Y10S977/773 , Y10S977/927
摘要： The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.
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3.发明申请公开(公告)号：US20170151174A1
公开(公告)日：2017-06-01
申请号：US15308770
申请日：2015-05-06
IPC分类号： A61K9/127 , A61K31/704 , A61K9/16 , A61K31/337 , A61K49/00 , A61K41/00 , A61K33/24
CPC分类号： A61K9/127 , A61K9/1611 , A61K31/337 , A61K31/704 , A61K33/24 , A61K41/00 , A61K47/6911 , A61K49/0034 , A61K49/0084 , A61K49/186
摘要： The present invention relates to a composition comprising liposomes, wherein the liposomes preferably comprise phospholipids, magnetic nanoparticles, an imaging agent and an imaging label, and at least one active agent. The liposomes are capable of releasing the at least one active agent into a target environment by the concomitant action of a phospholipase that is able to degrade at least one of said one or more phospholipids and an alternating magnetic field.
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公开(公告)号：US20130039848A1
公开(公告)日：2013-02-14
申请号：US13381209
申请日：2010-07-02
申请人： Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
发明人： Michelle Bradbury , Ulrich Wiesner , Oula Penate Medina , Hoosweng Ow , Andrew Burns , Jason Lewis , Steven Larson
IPC分类号： A61K49/00 , A61K49/06 , A61K49/04 , A61K9/14 , A61K39/395 , A61K31/7088 , A61K48/00 , A61K31/56 , A61K31/713 , A61K31/7105 , G01N21/64 , A61P35/00 , A61P31/04 , A61P31/00 , A61P39/06 , A61P37/06 , A61P7/02 , A61P9/08 , A61P29/00 , A61K51/12 , B82Y5/00 , B82Y15/00
CPC分类号： A61K51/1244 , A61K9/5115 , A61K9/5146 , A61K9/5169 , A61K49/0019 , A61K49/0032 , A61K49/0054 , A61K49/0056 , A61K49/0093 , A61K51/08 , A61K51/082 , A61K51/086 , A61K51/1255 , B82Y5/00 , B82Y15/00 , G01N33/54346 , G01N33/552 , G01N33/574 , G01N33/582 , G01N33/587 , G01N33/60 , Y10S977/773 , Y10S977/927
摘要： The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.
摘要翻译： 本发明提供一种荧光二氧化硅基纳米颗粒，其允许精确检测，表征，监测和治疗诸如癌症的疾病。纳米颗粒具有位于纳米颗粒内的荧光化合物，并且具有比游离荧光素更高的亮度和荧光量子产率 化合物为了促进纳米颗粒的有效的尿液排泄，可以用有机聚合物如聚乙二醇（PEG）包被）（PEG）小粒径的纳米颗粒，二氧化硅基底和有机聚合物涂层在施用时使纳米颗粒的毒性最小化 在体内纳米颗粒还可以与能够结合与特定细胞类型相关的细胞成分的配体缀合，例如肿瘤标记物A治疗剂可以连接到纳米颗粒放射性核素/放射性金属或顺磁性离子可以与 纳米颗粒以允许纳米颗粒可以通过各种i检测 搜索技巧
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