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公开(公告)号：US5877165A
公开(公告)日：1999-03-02
申请号：US874548
申请日：1997-06-13
IPC分类号： A61K41/00 , A61K51/04 , C07D487/22 , A61K31/69 , C07F5/05
CPC分类号： A61K51/0485 , A61K41/0071 , A61K41/0095 , C07D487/22
摘要： The present invention covers boronated porphyrins containing multiple carborane cages which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies such as boron neutron capture therapy and photodynamic therapy.
摘要翻译： 本发明包括含有多个碳硼烷笼的硼化卟啉，其选择性地积聚在照射体积内的肿瘤组织中，因此可用于癌症治疗如硼中子捕获治疗和光动力学治疗。
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2.发明授权Metalloporphyrins and their uses as radiosensitizers for radiation therapy 有权金属卟啉及其作为辐射敏化剂用于放射治疗的用途公开(公告)号：US06759403B2
公开(公告)日：2004-07-06
申请号：US10117010
申请日：2002-04-05
申请人： Michiko Miura , Daniel N. Slatkin
发明人： Michiko Miura , Daniel N. Slatkin
IPC分类号： C07D48722
CPC分类号： A61K51/0485 , A61K31/409 , A61K41/0038 , A61K41/0095 , C07D487/22
摘要： The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages having the structure which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron—capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.
摘要翻译： 本发明涉及含有作为活性成分的硼化卟啉的卤化衍生物的放射增敏剂，其含有多个碳硼烷笼，其具有选择性地累积在照射体积内的肿瘤组织中的结构，因此可用于癌症治疗，包括但不限于硼中子捕获 治疗和光动力疗法。 本发明还涉及在肿瘤成像和癌症治疗中使用这些放射增敏剂的方法。
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3.发明授权Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy 失效用于核医学和硼中子捕获治疗的卤化硫代氢硼烷
公开(公告)号：US5653957A
公开(公告)日：1997-08-05
申请号：US740693
申请日：1996-11-01
申请人： Michiko Miura , Daniel N. Slatkin
发明人： Michiko Miura , Daniel N. Slatkin
CPC分类号： C01B35/14 , A61K41/0095
摘要： A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
摘要翻译： 公开了一种用于治疗肿瘤的硼中子俘获治疗方法。 该方法包括向患者施用碘化硫化氢化硼烷，含硼-10的化合物。 肿瘤的部位是局部化的。 通过可视化在肿瘤处增加碘标记化合物的浓度。 然后用具有对中子俘获有效的能量分布的中子束照射靶向的肿瘤。 肿瘤的破坏发生在由硼-10核捕获的入射中子的继发性组织的高LET粒子照射。 公开了特别适用于本发明方法的碘化硫化氢硼烷。 在优选的实施方案中，具有式Na4B12I11SSB12I11的化合物或该化合物的其它药学上可接受的盐可以给予硼中子俘获治疗的癌症患者。
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4.发明授权Use of novel metalloporphyrins as imageable tumor-targeting agents for radiation therapy 失效使用新型金属卟啉作为放射治疗的可成像肿瘤靶向剂公开(公告)号：US06951640B2
公开(公告)日：2005-10-04
申请号：US10375454
申请日：2003-02-27
申请人： Michiko Miura , Daniel N. Slatkin
发明人： Michiko Miura , Daniel N. Slatkin
IPC分类号： A61K31/409 , A61K41/00 , A61K51/04 , A61P35/00 , C07D487/22 , A61K51/00 , A01N55/02 , C07F5/00
CPC分类号： A61K51/0485 , A61K31/409 , A61K41/0038 , A61K41/0095 , C07D487/22
摘要： The present invention covers halogenated derivatives of boronated phorphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.
摘要翻译： 本发明包括含有多种碳硼烷笼的硼化卟啉的卤化衍生物，其具有选择性地积累在照射体积内的肿瘤组织中的配方，因此可用于癌症治疗，包括但不限于硼中子俘获治疗和光动力疗法。 本发明还涉及在肿瘤成像和癌症治疗中使用硼化卟啉的这些卤化衍生物的方法。
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5.发明授权Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy 有权金属卟啉及其用作放射治疗的可成像肿瘤靶向剂公开(公告)号：US06566517B2
公开(公告)日：2003-05-20
申请号：US09874203
申请日：2001-06-06
申请人： Michiko Miura , Daniel N. Slatkin
发明人： Michiko Miura , Daniel N. Slatkin
IPC分类号： C07D48722
CPC分类号： A61K51/0485 , A61K31/409 , A61K41/0038 , A61K41/0095 , C07D487/22
摘要： The present invention covers halogenated derivatives of boronated porphyrins containing multiple carborane cages having the formula which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron- capture therapy and photodynamic therapy. The present invention also covers methods for using these halogenated derivatives of boronated porphyrins in tumor imaging and cancer treatment.
摘要翻译： 本发明包括含有多个碳硼烷笼的硼化卟啉的卤化衍生物，其具有选择性地积累在照射体积内的肿瘤组织中，因此可用于癌症治疗，包括但不限于硼中子捕获治疗和光动力疗法。 本发明还涉及在肿瘤成像和癌症治疗中使用硼化卟啉的这些卤化衍生物的方法。
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6.发明授权Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy 失效用于核医学和硼中子捕获治疗的卤化硫代氢硼烷
公开(公告)号：US5612017A
公开(公告)日：1997-03-18
申请号：US427673
申请日：1995-04-24
申请人： Michiko Miura , Daniel N. Slatkin
发明人： Michiko Miura , Daniel N. Slatkin
CPC分类号： C01B35/14 , A61K41/0095
摘要： A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
摘要翻译： 公开了一种用于治疗肿瘤的硼中子俘获治疗方法。 该方法包括向患者施用碘化硫化氢化硼烷，含硼-10的化合物。 通过观察肿瘤上碘标记化合物浓度的增加，肿瘤位点是局部化的。 然后用具有对中子俘获有效的能量分布的中子束照射靶向的肿瘤。 肿瘤的破坏发生在由硼-10核捕获的入射中子的继发性组织的高LET粒子照射。 公开了特别适用于本发明方法的碘化硫化氢硼烷。 在优选的实施方案中，具有式Na4B12I11SSB12I11的化合物或该化合物的其它药学上可接受的盐可以给予硼中子俘获治疗的癌症患者。
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7.发明授权Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy 失效用于核医学和硼中子捕获治疗的卤化硫代氢硼烷
公开(公告)号：US5455022A
公开(公告)日：1995-10-03
申请号：US118300
申请日：1993-09-09
申请人： Michiko Miura , Daniel N. Slatkin
发明人： Michiko Miura , Daniel N. Slatkin
CPC分类号： C01B35/14 , A61K41/0095
摘要： A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.
摘要翻译： 公开了一种用于治疗肿瘤的硼中子俘获治疗方法。 该方法包括向患者施用碘化硫化氢化硼烷，含硼-10的化合物。 通过观察肿瘤上碘标记化合物浓度的增加，肿瘤位点是局部化的。 然后用具有对中子俘获有效的能量分布的中子束照射靶向的肿瘤。 肿瘤的破坏是由于由硼-10核捕获的入射中子的次要组织的高LET粒子照射而发生的。 公开了特别适用于本发明方法的碘化硫化氢硼烷。 在优选的实施方案中，具有式Na4B12I11SSB12I11的化合物或该化合物的其它药学上可接受的盐可以给予硼中子俘获治疗的癌症患者。
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公开(公告)号：US06299873B1
公开(公告)日：2001-10-09
申请号：US09334312
申请日：1999-06-16
IPC分类号： A61K3500
CPC分类号： A61K41/0095 , A61K39/0011 , A61K2039/5152 , A61K2300/00
摘要： A method of optimizing malignancy therapy includes surgical removal or reduction of the body burden of malignant cells and retention of some of those cells for subsequent use in immunotherapy. Boron neutron-capture therapy is employed at a radiation dosage below the threshold for normal tissue necrosis to provide preservation of normal tissue structure. Normal tissue tolerable limits are in the range of 10-13 GY-Eq. The removed tumor cells are altered by radiation or genetically to render them incapable of unlimited clonogenic propagation and then reinjected using multiple sequenced injections.
摘要翻译： 优化恶性肿瘤治疗的方法包括手术切除或减少恶性细胞的身体负担，并保留其中一些细胞以供随后用于免疫治疗。 采用硼中子俘获疗法，其辐射剂量低于正常组织坏死阈值，以提供正常组织结构的保存。 正常的组织耐受极限在10-13 GY-Eq的范围内。 去除的肿瘤细胞通过放射或遗传改变以使其不能无限制地克隆形成繁殖，然后使用多次测序注射进行再注射。
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公开(公告)号：US5339347A
公开(公告)日：1994-08-16
申请号：US52927
申请日：1993-04-27
CPC分类号： A61N5/1084 , A61B90/10 , A61N2005/1091 , A61N5/1064
摘要： A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.
摘要翻译： 一种对患者进行放射治疗的方法，包括将目标物（通常为肿瘤）暴露于治疗剂量的高能量电磁辐射（优选X射线辐射），其形式为至少两个非重叠的微束辐射束 具有小于约1毫米宽度的微束。 暴露于微束的靶组织在暴露期间接受辐射剂量，超过这种组织可以存活的最大剂量。 微束之间的非目标组织接受低于可由组织存活的阈值量的辐射的剂量，从而允许非目标组织再生。 微束可以从一个方向或多于一个方向引导靶，在这种情况下，微束在靶组织内重叠，从而增强照射的致死作用，同时保护周围的健康组织。
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公开(公告)号：US4845729A
公开(公告)日：1989-07-04
申请号：US158495
申请日：1988-02-22
IPC分类号： A61B6/00
摘要： Improved methods and apparatus for in vivo measurement of the skeletal lead burden of a patient and for diagnosis of lead toxicity are disclosed. The apparatus comprises an x-ray tube emitting soft low energy x-rays from a silver anode, a polarizer for polarizing the emitted x-rays, and a detector for detecting photons fluoresced from atoms in the patient's tibia upon irradiation by the polarized x-rays. The fluoresced photons are spectrally analyzed to determine their energy distribution. Peaks indicating the presence of lead are identified if the patient has relatively high bone lead content. The data may be compared to data recorded with respect to a similar test performed on patients having also had the conventional EDTA chelation tests performed thereon in order to correlate the test results with respect to a particular patient to the conventionally accepted EDTA chelation test.
摘要翻译： 公开了用于体内测量患者骨骼铅负荷和铅毒性诊断的改进方法和装置。 该装置包括发射来自银阳极的低能量x射线的X射线管，用于偏振发射的X射线的偏振器，以及用于检测由偏振x射线照射时患者胫骨中的原子发荧光的光子的检测器， 射线 对荧光光子进行光谱分析以确定其能量分布。 如果患者的骨铅含量相对较高，则识别出铅的存在的峰。 可以将数据与对于还进行了常规EDTA螯合试验的患者进行的类似测试记录的数据进行比较，以便将测试结果相对于特定患者与常规接受的EDTA螯合试验相关联。
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