利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.018 秒)

    Method for improvement of radiation therapy of malignant tumors
    1.
    发明授权
    Method for improvement of radiation therapy of malignant tumors 失效
    改善恶性肿瘤放射治疗的方法

    公开(公告)号：US06299873B1

    公开(公告)日：2001-10-09

    申请号：US09334312

    申请日：1999-06-16

    申请人： Henry M. Smilowitz ,  Jeffrey A. Coderre ,  Daniel N. Slatkin

    发明人： Henry M. Smilowitz ,  Jeffrey A. Coderre ,  Daniel N. Slatkin

    IPC分类号： A61K3500

    CPC分类号： A61K41/0095 ,  A61K39/0011 ,  A61K2039/5152 ,  A61K2300/00

    摘要： A method of optimizing malignancy therapy includes surgical removal or reduction of the body burden of malignant cells and retention of some of those cells for subsequent use in immunotherapy. Boron neutron-capture therapy is employed at a radiation dosage below the threshold for normal tissue necrosis to provide preservation of normal tissue structure. Normal tissue tolerable limits are in the range of 10-13 GY-Eq. The removed tumor cells are altered by radiation or genetically to render them incapable of unlimited clonogenic propagation and then reinjected using multiple sequenced injections.

    摘要翻译： 优化恶性肿瘤治疗的方法包括手术切除或减少恶性细胞的身体负担，并保留其中一些细胞以供随后用于免疫治疗。 采用硼中子俘获疗法，其辐射剂量低于正常组织坏死阈值，以提供正常组织结构的保存。 正常的组织耐受极限在10-13 GY-Eq的范围内。 去除的肿瘤细胞通过放射或遗传改变以使其不能无限制地克隆形成繁殖，然后使用多次测序注射进行再注射。

    Method for microbeam radiation therapy
    2.
    发明授权
    Method for microbeam radiation therapy 失效
    微波辐射治疗方法

    公开(公告)号：US5339347A

    公开(公告)日：1994-08-16

    申请号：US52927

    申请日：1993-04-27

    申请人： Daniel N. Slatkin ,  F. Avraham Dilmanian ,  Per O. Spanne

    发明人： Daniel N. Slatkin ,  F. Avraham Dilmanian ,  Per O. Spanne

    IPC分类号： A61B19/00 ,  A61N5/10

    CPC分类号： A61N5/1084 ,  A61B90/10 ,  A61N2005/1091 ,  A61N5/1064

    摘要： A method of performing radiation therapy on a patient, involving exposing a target, usually a tumor, to a therapeutic dose of high energy electromagnetic radiation, preferably X-ray radiation, in the form of at least two non-overlapping microbeams of radiation, each microbeam having a width of less than about 1 millimeter. Target tissue exposed to the microbeams receives a radiation dose during the exposure that exceeds the maximum dose that such tissue can survive. Non-target tissue between the microbeams receives a dose of radiation below the threshold amount of radiation that can be survived by the tissue, and thereby permits the non-target tissue to regenerate. The microbeams may be directed at the target from one direction, or from more than one direction in which case the microbeams overlap within the target tissue enhancing the lethal effect of the irradiation while sparing the surrounding healthy tissue.

    摘要翻译： 一种对患者进行放射治疗的方法，包括将目标物（通常为肿瘤）暴露于治疗剂量的高能量电磁辐射（优选X射线辐射），其形式为至少两个非重叠的微束辐射束 具有小于约1毫米宽度的微束。 暴露于微束的靶组织在暴露期间接受辐射剂量，超过这种组织可以存活的最大剂量。 微束之间的非目标组织接受低于可由组织存活的阈值量的辐射的剂量，从而允许非目标组织再生。 微束可以从一个方向或多于一个方向引导靶，在这种情况下，微束在靶组织内重叠，从而增强照射的致死作用，同时保护周围的健康组织。

    Method and apparatus for diagnosis of lead toxicity
    3.
    发明授权
    Method and apparatus for diagnosis of lead toxicity 失效
    用于诊断铅毒性的方法和装置

    公开(公告)号：US4845729A

    公开(公告)日：1989-07-04

    申请号：US158495

    申请日：1988-02-22

    申请人： John F. Rosen ,  Daniel N. Slatkin ,  Lucian Wielopolski

    发明人： John F. Rosen ,  Daniel N. Slatkin ,  Lucian Wielopolski

    IPC分类号： A61B6/00

    CPC分类号： A61B6/505 ,  A61B6/485

    摘要： Improved methods and apparatus for in vivo measurement of the skeletal lead burden of a patient and for diagnosis of lead toxicity are disclosed. The apparatus comprises an x-ray tube emitting soft low energy x-rays from a silver anode, a polarizer for polarizing the emitted x-rays, and a detector for detecting photons fluoresced from atoms in the patient's tibia upon irradiation by the polarized x-rays. The fluoresced photons are spectrally analyzed to determine their energy distribution. Peaks indicating the presence of lead are identified if the patient has relatively high bone lead content. The data may be compared to data recorded with respect to a similar test performed on patients having also had the conventional EDTA chelation tests performed thereon in order to correlate the test results with respect to a particular patient to the conventionally accepted EDTA chelation test.

    摘要翻译： 公开了用于体内测量患者骨骼铅负荷和铅毒性诊断的改进方法和装置。 该装置包括发射来自银阳极的低能量x射线的X射线管，用于偏振发射的X射线的偏振器，以及用于检测由偏振x射线照射时患者胫骨中的原子发荧光的光子的检测器， 射线 对荧光光子进行光谱分析以确定其能量分布。 如果患者的骨铅含量相对较高，则识别出铅的存在的峰。 可以将数据与对于还进行了常规EDTA螯合试验的患者进行的类似测试记录的数据进行比较，以便将测试结果相对于特定患者与常规接受的EDTA螯合试验相关联。

    Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2
    6.
    依法登记的发明
    Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2 失效
    来自[10B] NA4B24H22S2的肿瘤，大脑和血液中的硼摄取

    公开(公告)号：USH505H

    公开(公告)日：1988-08-02

    申请号：US838494

    申请日：1986-03-11

    申请人： Daniel N. Slatkin ,  Peggy L. Micca ,  Ralph G. Fairchild

    发明人： Daniel N. Slatkin ,  Peggy L. Micca ,  Ralph G. Fairchild

    IPC分类号： A61K41/00 ,  A61K51/04

    CPC分类号： A61K41/0095 ,  A61K51/04 ,  A61K2121/00

    摘要： A stable boronated (.sup.10 B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [.sup.10 B]Na.sub.4 B.sub.24 H.sub.22 S.sub.2, at a dose of about 200 .mu.g .sup.10 B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 .mu.g .sup.10 B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of .sup.10 B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of .sup.10 B in the tumor.

    Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy
    10.
    发明授权
    Halogenated sulfidohydroboranes for nuclear medicine and boron neutron capture therapy 失效
    用于核医学和硼中子捕获治疗的卤化硫代氢硼烷

    公开(公告)号：US5653957A

    公开(公告)日：1997-08-05

    申请号：US740693

    申请日：1996-11-01

    申请人： Michiko Miura ,  Daniel N. Slatkin

    发明人： Michiko Miura ,  Daniel N. Slatkin

    IPC分类号： A61K41/00 ,  C01B35/14 ,  C01B35/18 ,  A61K51/00

    CPC分类号： C01B35/14 ,  A61K41/0095

    摘要： A method for performing boron neutron capture therapy for the treatment of tumors is disclosed. The method includes administering to a patient an iodinated sulfidohydroborane, a boron-10-containing compound. The site of the tumor is localized. by visualizing the increased concentration of the iodine labelled compound at the tumor. The targeted tumor is then irradiated with a beam of neutrons having an energy distribution effective for neutron capture. Destruction of the tumor occurs due to high LET particle irradiation of the tissue secondary to the incident neutrons being captured by the boron-10 nuclei. Iodinated sulfidohydroboranes are disclosed which are especially suitable for the method of the invention. In a preferred embodiment, a compound having the formula Na.sub.4 B.sub.12 I.sub.11 SSB.sub.12 I.sub.11, or another pharmaceutically acceptable salt of the compound, may be administered to a cancer patient for boron neutron capture therapy.

    摘要翻译： 公开了一种用于治疗肿瘤的硼中子俘获治疗方法。 该方法包括向患者施用碘化硫化氢化硼烷，含硼-10的化合物。 肿瘤的部位是局部化的。 通过可视化在肿瘤处增加碘标记化合物的浓度。 然后用具有对中子俘获有效的能量分布的中子束照射靶向的肿瘤。 肿瘤的破坏发生在由硼-10核捕获的入射中子的继发性组织的高LET粒子照射。 公开了特别适用于本发明方法的碘化硫化氢硼烷。 在优选的实施方案中，具有式Na4B12I11SSB12I11的化合物或该化合物的其它药学上可接受的盐可以给予硼中子俘获治疗的癌症患者。