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    Deformable mirror and device for observing retina of eye
    1.
    发明授权
    Deformable mirror and device for observing retina of eye 失效
    用于观察眼睛视网膜的变形镜和装置

    公开(公告)号：US07345808B2

    公开(公告)日：2008-03-18

    申请号：US11175393

    申请日：2005-07-07

    申请人： Michiko Nakanishi ,  Akio Kobayashi ,  Isao Minegishi ,  Ayako Iijima

    发明人： Michiko Nakanishi ,  Akio Kobayashi ,  Isao Minegishi ,  Ayako Iijima

    IPC分类号： G02B26/00

    CPC分类号： G03B15/14 ,  A61B3/14

    摘要： A deformable mirror, in which the distance between an electrode substrate and a membrane can be accurately maintained and which can be produced at a low material cost, is provided. The deformable mirror comprises: an electrode substrate 11 having a plurality of electrodes (16a, 16b, 16c, 16d and 16e) formed on a surface of the electrode substrate; a silicon membrane 13 having a counter electrode opposed to the plurality of electrodes formed on the electrode substrate 11; a reflection section 15 provided on the side of the silicon membrane 13 opposite the counter electrode; and a support plate 19 integrally bonded to the electrode substrate 11 for restraining the displacements of the plurality of electrodes which adversely affect the deformation of the silicon membrane 13, in which a plurality of layers of wiring patterns (11a, 11b, 11c, 11d and 11e) for supplying drive voltages to the plurality of electrodes are formed in the electrode substrate 11.

    摘要翻译： 提供了可以精确地保持电极基板和膜之间的距离并且可以以低材料成本生产的可变形反射镜。 可变形反射镜包括：电极基板11，其具有形成在电极基板的表面上的多个电极（16a，16b，16c，16d和16e） 具有与形成在电极基板11上的多个电极相对的对置电极的硅膜13; 设置在与对置电极相对的硅膜13一侧的反射部15; 以及与电极基板11一体地结合的支撑板19，用于抑制对硅膜13的变形产生不利影响的多个电极的位移，其中多层布线图案（11a，11b，11c ，11d和11e）用于在多个电极中提供驱动电压。

    Deformable mirror and device for observing retina of eye
    2.
    发明申请
    Deformable mirror and device for observing retina of eye 失效
    用于观察眼睛视网膜的变形镜和装置

    公开(公告)号：US20060159490A1

    公开(公告)日：2006-07-20

    申请号：US11175393

    申请日：2005-07-07

    申请人： Michiko Nakanishi ,  Akio Kobayashi ,  Isao Minegishi ,  Ayako Iijima

    发明人： Michiko Nakanishi ,  Akio Kobayashi ,  Isao Minegishi ,  Ayako Iijima

    IPC分类号： G03G15/041

    CPC分类号： G03B15/14 ,  A61B3/14

    摘要： A deformable mirror, in which the distance between an electrode substrate and a membrane can be accurately maintained and which can be produced at a low material cost, is provided. The deformable mirror comprises: an electrode substrate 11 having a plurality of electrodes (16a, 16b, 16c, 16d and 16e) formed on a surface of the electrode substrate; a silicon membrane 13 having a counter electrode opposed to the plurality of electrodes formed on the electrode substrate 11; a reflection section 15 provided on the side of the silicon membrane 13 opposite the counter electrode; and a support plate 19 integrally bonded to the electrode substrate 11 for restraining the displacements of the plurality of electrodes which adversely affect the deformation of the silicon membrane 13, in which a plurality of layers of wiring patterns (11a, 11b, 11c, 11d and 11e) for supplying drive voltages to the plurality of electrodes are formed in the electrode substrate 11.

    摘要翻译： 提供了可以精确地保持电极基板和膜之间的距离并且可以以低材料成本生产的可变形反射镜。 可变形反射镜包括：电极基板11，其具有形成在电极基板的表面上的多个电极（16a，16b，16c，16d和16e） 具有与形成在电极基板11上的多个电极相对的对置电极的硅膜13; 设置在与对置电极相对的硅膜13一侧的反射部15; 以及与电极基板11一体地结合的支撑板19，用于抑制对硅膜13的变形产生不利影响的多个电极的位移，其中多层布线图案（11a，11b，11c ，11d和11e）用于在多个电极中提供驱动电压。

    COMPOSITION FOR NUCLEIC-ACID TRANSFECTION
    4.
    发明申请
    COMPOSITION FOR NUCLEIC-ACID TRANSFECTION 有权
    用于核酸转运的组合物

    公开(公告)号：US20090239222A1

    公开(公告)日：2009-09-24

    申请号：US12306620

    申请日：2007-06-29

    申请人： Hiroshi Kikuchi ,  Hideo Kobayashi ,  Kouichi Hashimoto ,  Ayako Iijima ,  Daigo Asano

    发明人： Hiroshi Kikuchi ,  Hideo Kobayashi ,  Kouichi Hashimoto ,  Ayako Iijima ,  Daigo Asano

    IPC分类号： C12Q1/68 ,  C07C233/00

    CPC分类号： C12N15/88 ,  A61K9/1272

    摘要： To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells.The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.

    摘要翻译： 提供显示低细胞毒性的核酸转染组合物，其有助于核酸转染入细胞，并且其改善核酸在细胞中的表达。 本发明提供一种用于将核酸转染入细胞的组合物，包括由下式（I）表示的化合物（其中R 1和R 2各自彼此相同或不同，表示饱和或不饱和的烃基 R 3表示C 1-6烷基或C 1-6羟基烷基; m表示1〜10的整数，X表示卤素原子）和磷脂。

    Composition for nucleic-acid transfection
    5.
    发明授权
    Composition for nucleic-acid transfection 有权
    用于核酸转染的组合物

    公开(公告)号：US08227248B2

    公开(公告)日：2012-07-24

    申请号：US12306620

    申请日：2007-06-29

    申请人： Hiroshi Kikuchi ,  Hideo Kobayashi ,  Kouichi Hashimoto ,  Ayako Iijima ,  Daigo Asano

    发明人： Hiroshi Kikuchi ,  Hideo Kobayashi ,  Kouichi Hashimoto ,  Ayako Iijima ,  Daigo Asano

    IPC分类号： C12N15/88

    CPC分类号： C12N15/88 ,  A61K9/1272

    摘要： To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells. The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.

    摘要翻译： 提供显示低细胞毒性的核酸转染组合物，其有助于核酸转染入细胞，并且其改善核酸在细胞中的表达。 本发明提供一种用于将核酸转染入细胞的组合物，包括由下式（I）表示的化合物（其中R 1和R 2各自彼此相同或不同，表示饱和或不饱和的烃基 R 3表示C 1-6烷基或C 1-6羟基烷基; m表示1〜10的整数，X表示卤素原子）和磷脂。

    COMPOSITION FOR INTRODUCTION OF NUCLEIC ACID
    6.
    发明申请
    COMPOSITION FOR INTRODUCTION OF NUCLEIC ACID 审中-公开
    用于引入核酸的组合物

    公开(公告)号：US20090233366A1

    公开(公告)日：2009-09-17

    申请号：US12432577

    申请日：2009-04-29

    申请人： Hiroshi Kikuchi ,  Kouichi Hashimoto ,  Hideo Kobayashi ,  Ayako Iijima ,  Daigo Asano

    发明人： Hiroshi Kikuchi ,  Kouichi Hashimoto ,  Hideo Kobayashi ,  Ayako Iijima ,  Daigo Asano

    IPC分类号： C12N15/88 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08

    CPC分类号： A61K9/127 ,  A61K48/0041

    摘要： Composition with weak cytotoxicity for introducing a nucleic acid, such as a short oligonucleotide or a gene, into a cell for expression of the gene in the cell. The composition includes a lipid and a compound represented by a formula (I): (R1)n-R2-R3  (I) wherein (R1)n represents a polyamino acid residue consisting of a total of n amino acid residues, which are identical to or different from one another, the n residues being selected from an arginine residue, a lysine residue, and a histidine residue, and n being an integer of from 4 to 16; R2 represents a single bond or an amino acid residue; and R3 represents a phospholipid residue with 1 or 2 identical or different unsaturated fatty acid residues having from 12 to 20 carbon atoms. The composition is administered or supplied to a cell together with a nucleic acid.

    摘要翻译： 用于将核酸如短寡核苷酸或基因导入用于在细胞中表达基因的细胞的细胞毒性弱的组合物。 组合物包括脂质和由式（I）表示的化合物：<？in-line-formula description =“In-line Formulas”end =“lead”？>（R1）n-R2-R3（I） 其中（R1）n表示由总共n个氨基酸残基组成的聚氨基酸残基，它们彼此相同或不同。 n残基选自精氨酸残基，赖氨酸残基和组氨酸残基，n为4〜16的整数， R2表示单键或氨基酸残基; R3表示具有1或2个相同或不同的具有12至20个碳原子的不饱和脂肪酸残基的磷脂残基。 组合物与核酸一起施用或提供给细胞。