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公开(公告)号:US20090239222A1
公开(公告)日:2009-09-24
申请号:US12306620
申请日:2007-06-29
IPC分类号: C12Q1/68 , C07C233/00
CPC分类号: C12N15/88 , A61K9/1272
摘要: To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells.The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.
摘要翻译: 提供显示低细胞毒性的核酸转染组合物,其有助于核酸转染入细胞,并且其改善核酸在细胞中的表达。 本发明提供一种用于将核酸转染入细胞的组合物,包括由下式(I)表示的化合物(其中R 1和R 2各自彼此相同或不同,表示饱和或不饱和的烃基 R 3表示C 1-6烷基或C 1-6羟基烷基; m表示1〜10的整数,X表示卤素原子)和磷脂。
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公开(公告)号:US20130149369A1
公开(公告)日:2013-06-13
申请号:US13249120
申请日:2011-09-29
申请人: Hiroshi KIKUCHI , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人: Hiroshi KIKUCHI , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号: A61K31/7088
CPC分类号: A61K31/7088 , A61K48/0025
摘要: The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译: 本发明提供了一种显示低细胞毒性的核酸转染组合物,其有利于有效的核酸转染到细胞中,并且其改善细胞中核酸的表达。 用于将核酸转染入细胞的组合物含有二(C 12-16烷基)二甲基卤化铵和磷脂。
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公开(公告)号:US08227248B2
公开(公告)日:2012-07-24
申请号:US12306620
申请日:2007-06-29
IPC分类号: C12N15/88
CPC分类号: C12N15/88 , A61K9/1272
摘要: To provide a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates a nucleic acid transfection into cells, and which improves expression of the nucleic acid in the cells. The invention provides a composition for transfecting a nucleic acid into a cell, including a compound represented by the following formula (I) (wherein each of R1 and R2, which are identical to or different from each other, represents a saturated or unsaturated hydrocarbon group; R3 represents a C1-6 alkyl group or a C1-6 hydroxyalkyl group; m is an integer from 1 to 10; and X represents a halogen atom), and a phospholipid.
摘要翻译: 提供显示低细胞毒性的核酸转染组合物,其有助于核酸转染入细胞,并且其改善核酸在细胞中的表达。 本发明提供一种用于将核酸转染入细胞的组合物,包括由下式(I)表示的化合物(其中R 1和R 2各自彼此相同或不同,表示饱和或不饱和的烃基 R 3表示C 1-6烷基或C 1-6羟基烷基; m表示1〜10的整数,X表示卤素原子)和磷脂。
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公开(公告)号:US20090233366A1
公开(公告)日:2009-09-17
申请号:US12432577
申请日:2009-04-29
CPC分类号: A61K9/127 , A61K48/0041
摘要: Composition with weak cytotoxicity for introducing a nucleic acid, such as a short oligonucleotide or a gene, into a cell for expression of the gene in the cell. The composition includes a lipid and a compound represented by a formula (I): (R1)n-R2-R3 (I) wherein (R1)n represents a polyamino acid residue consisting of a total of n amino acid residues, which are identical to or different from one another, the n residues being selected from an arginine residue, a lysine residue, and a histidine residue, and n being an integer of from 4 to 16; R2 represents a single bond or an amino acid residue; and R3 represents a phospholipid residue with 1 or 2 identical or different unsaturated fatty acid residues having from 12 to 20 carbon atoms. The composition is administered or supplied to a cell together with a nucleic acid.
摘要翻译: 用于将核酸如短寡核苷酸或基因导入用于在细胞中表达基因的细胞的细胞毒性弱的组合物。 组合物包括脂质和由式(I)表示的化合物:<?in-line-formula description =“In-line Formulas”end =“lead”?>(R1)n-R2-R3(I) 其中(R1)n表示由总共n个氨基酸残基组成的聚氨基酸残基,它们彼此相同或不同。 n残基选自精氨酸残基,赖氨酸残基和组氨酸残基,n为4〜16的整数, R2表示单键或氨基酸残基; R3表示具有1或2个相同或不同的具有12至20个碳原子的不饱和脂肪酸残基的磷脂残基。 组合物与核酸一起施用或提供给细胞。
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公开(公告)号:US09095600B2
公开(公告)日:2015-08-04
申请号:US12562887
申请日:2009-09-18
申请人: Tetsuo Minamino , Masafumi Kitakaze , Masatsugu Hori , Hiroyuki Takahama , Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako Iijima , Daigo Asano
发明人: Tetsuo Minamino , Masafumi Kitakaze , Masatsugu Hori , Hiroyuki Takahama , Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako Iijima , Daigo Asano
IPC分类号: A61K9/127 , A61K31/7076
CPC分类号: A61K31/7076 , A61K9/127
摘要: The present invention relates to a novel preventive and/or therapeutic drug for myocardial infarction.The present invention provides a preventive and/or therapeutic drug for myocardial infarction or myocardial ischemia-reperfusion injury, the drug containing a lipid membrane structure retaining adenosine.
摘要翻译: 本发明涉及用于心肌梗塞的新型预防和/或治疗药物。 本发明提供了用于心肌梗塞或心肌缺血 - 再灌注损伤的预防和/或治疗药物,该药物含有保留腺苷的脂质膜结构。
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公开(公告)号:US20100098753A1
公开(公告)日:2010-04-22
申请号:US12562887
申请日:2009-09-18
申请人: Tetsuo MINAMINO , Masafumi Kitakaze , Masatsugu Hori , Hiroyuki Takahama , Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako IIJIMA , Daigo Asano
发明人: Tetsuo MINAMINO , Masafumi Kitakaze , Masatsugu Hori , Hiroyuki Takahama , Hiroshi Kikuchi , Kouichi Hashimoto , Hideo Kobayashi , Ayako IIJIMA , Daigo Asano
IPC分类号: A61K9/127 , A61P9/10 , A61K31/7076
CPC分类号: A61K31/7076 , A61K9/127
摘要: The present invention relates to a novel preventive and/or therapeutic drug for myocardial infarction.The present invention provides a preventive and/or therapeutic drug for myocardial infarction or myocardial ischemia-reperfusion injury, the drug containing a lipid membrane structure retaining adenosine.
摘要翻译: 本发明涉及用于心肌梗塞的新型预防和/或治疗药物。 本发明提供了用于心肌梗塞或心肌缺血 - 再灌注损伤的预防和/或治疗药物,该药物含有保留腺苷的脂质膜结构。
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公开(公告)号:US20100055684A1
公开(公告)日:2010-03-04
申请号:US12306993
申请日:2007-06-29
申请人: Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人: Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
CPC分类号: A61K31/7088 , A61K48/0025
摘要: The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译: 本发明提供了一种显示低细胞毒性的核酸转染组合物,其有利于有效的核酸转染到细胞中,并且其改善细胞中核酸的表达。 将核酸转染入细胞的组合物含有二(C 12-16烷基)二甲基卤化铵和磷脂。
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公开(公告)号:US08920832B2
公开(公告)日:2014-12-30
申请号:US13249120
申请日:2011-09-29
申请人: Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人: Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号: A61K31/7088 , A61K48/00
CPC分类号: A61K31/7088 , A61K48/0025
摘要: The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译: 本发明提供了一种显示低细胞毒性的核酸转染组合物,其有利于有效的核酸转染到细胞中,并且其改善细胞中核酸的表达。 用于将核酸转染入细胞的组合物含有二(C 12-16烷基)二甲基卤化铵和磷脂。
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公开(公告)号:US07943235B2
公开(公告)日:2011-05-17
申请号:US11969023
申请日:2008-01-03
CPC分类号: H01L21/6836 , C08G18/672 , C08L61/00 , C08L2666/16 , C09D175/16 , C09J7/385 , C09J133/02 , C09J2201/622 , C09J2203/326 , C09J2205/31 , H01L2221/68327 , Y10T428/28 , Y10T428/2809 , Y10T428/2852 , Y10T428/2883 , Y10T428/2891
摘要: An adhesive sheet for processing semiconductor substrates comprises a UV rays- and/or radiation-transmittable base film and an adhesive layer that undergoes a polymerization curing reaction by means of UV rays and/or radiation, wherein the adhesive layer is formed using a multifunctional acrylate oligomer and/or monomer having a double bond, and is blended so as to result in 1 double bond per total average molecular weight of 225 to 8000 as determined on the basis of the weight average molecular weight of the multifunctional acrylate oligomer and/or monomer.
摘要翻译: 用于处理半导体衬底的粘合片包括紫外线和/或辐射透射性底膜和通过紫外线和/或辐射进行聚合固化反应的粘合剂层,其中粘合剂层使用多官能丙烯酸酯 低聚物和/或具有双键的单体,并且根据多官能丙烯酸酯低聚物和/或单体的重均分子量测定,共混以达到每平均分子量为225至8000的1双键 。
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公开(公告)号:US07479317B2
公开(公告)日:2009-01-20
申请号:US11054826
申请日:2005-02-10
CPC分类号: C09J7/22 , C09J7/38 , C09J7/403 , C09J2203/326 , C09J2205/31 , H01L21/67132 , Y10S428/906 , Y10T428/14 , Y10T428/1476 , Y10T428/24355
摘要: An adhesive film in roll for wafer processing is constituted by laminated multiple layers including a base film, a radiation curing type adhesive layer, and a releasing film in this sequence, in which the arithmetic average roughness (Ra) of the side of the base film and/or releasing film opposite to the radiation curing type adhesive layer is 1 μm or more, and the weight of the radical polymerization initiator contained in the radiation curing type adhesive layer is less than 1000 ppm.
摘要翻译: 用于晶片处理的辊用粘合膜由具有基膜,辐射固化型粘合剂层和脱模膜的层叠多层构成,其中基膜的侧面的算术平均粗糙度(Ra) 和/或与放射线固化型粘合剂层相反的释放膜为1μm以上,辐射固化型粘合剂层中所含的自由基聚合引发剂的重量小于1000ppm。
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