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公开(公告)号：US08969060B2
公开(公告)日：2015-03-03
申请号：US13598944
申请日：2012-08-30
CPC分类号： C12N9/0006 , C12Y101/9901
摘要： The purpose of the present invention is to provide an FAD-conjugated glucose dehydrogenase that is hard to be inhibited by the inhibitors such as 1,10-phenanthroline.The present invention relates to a modified glucose dehydrogenase (GLD), comprising an amino acid sequence of a wild-type FAD-conjugated glucose dehydrogenase (GLD) represented by SEQ ID NO: 1 having a substitution of at least one amino acid residue selected from the group consisting of amino acid residues at positions 298, 338, 340, 341, 343, 352, 354, 424, 426, 431 and 432, wherein the modified GLD has a reduced susceptibility to an inhibitor, as compared with the wild-type GLD, especially to said modified GLD, which has 40% or more of a relative activity when determined in a system wherein the inhibitor coexists at a final concentration of 1 mM based on an enzymatic activity when determined in a system wherein the inhibitor does not coexist.
摘要翻译： 本发明的目的是提供难以被诸如1,10-菲咯啉的抑制剂抑制的FAD-缀合的葡萄糖脱氢酶。 本发明涉及一种修饰的葡萄糖脱氢酶（GLD），其包含由SEQ ID NO：1表示的野生型FAD-缀合的葡萄糖脱氢酶（GLD）的氨基酸序列，其具有至少一个选自以下的氨基酸残基： 由298,338,340,341,343,352,354,424,426,431和432位的氨基酸残基组成，其中与野生型相比，修饰的GLD对抑制剂的易感性降低 GLD，特别是所述修饰的GLD，当在其中抑制剂不共存的系统中测定时，当其在抑制剂基于酶活性的最终浓度为1mM共存时，其具有40％或更高的相对活性 。
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公开(公告)号：US20130065261A1
公开(公告)日：2013-03-14
申请号：US13598944
申请日：2012-08-30
CPC分类号： C12N9/0006 , C12Y101/9901
摘要： The purpose of the present invention is to provide an FAD-conjugated glucose dehydrogenase that is hard to be inhibited by the inhibitors such as 1,10-phenanthroline.The present invention relates to a modified glucose dehydrogenase (GLD), comprising an amino acid sequence of a wild-type FAD-conjugated glucose dehydrogenase (GLD) represented by SEQ ID NO: 1 having a substitution of at least one amino acid residue selected from the group consisting of amino acid residues at positions 298, 338, 340, 341, 343, 352, 354, 424, 426, 431 and 432, wherein the modified GLD has a reduced susceptibility to an inhibitor, as compared with the wild-type GLD, especially to said modified GLD, which has 40% or more of a relative activity when determined in a system wherein the inhibitor coexists at a final concentration of 1 mM based on an enzymatic activity when determined in a system wherein the inhibitor does not coexist.
摘要翻译： 本发明的目的是提供难以被诸如1,10-菲咯啉的抑制剂抑制的FAD-缀合的葡萄糖脱氢酶。 本发明涉及一种修饰的葡萄糖脱氢酶（GLD），其包含由SEQ ID NO：1表示的野生型FAD-缀合的葡萄糖脱氢酶（GLD）的氨基酸序列，其具有至少一个选自以下的氨基酸残基： 由298,338,340,341,343,352,354,424,426,431和432位的氨基酸残基组成，其中与野生型相比，修饰的GLD对抑制剂的易感性降低 GLD，特别是所述修饰的GLD，当在其中抑制剂不共存的系统中测定时，当其在抑制剂基于酶活性的最终浓度为1mM共存时，其具有40％或更高的相对活性 。
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公开(公告)号：US5029046A
公开(公告)日：1991-07-02
申请号：US443332
申请日：1989-12-01
申请人： Tsuyoshi Kameda
发明人： Tsuyoshi Kameda
CPC分类号： B60Q3/044 , B60Q3/008 , G01D11/26 , G01D11/28 , Y10S116/26 , Y10S116/36
摘要： An indicator gauge is disclosed, which comprises a meter panel. The meter panel includes a transparent base plate, a transparent colored layer applied to a rear surface of the transparent base platen and a fluorescent transparent substance layer applied to a front surface of the transparent base plate. A visual alarm indicator includes an opaque mark mounted to a given portion of the meter panel, a lamp housing having an open end which is connected to a rear surface of the meter panel in such a manner as to face toward the given portion and an electric lamp installed in the lamp housing. An ultraviolet lamp is arranged in front of the meter panel and generates ultraviolet rays upon electric energization thereof.
摘要翻译： 公开了一种指示器，其包括仪表板（1）。 仪表面板包括透明基板（1a），施加到透明基板（1a）的后表面的透明着色层（1b）和施加到透明基板的前表面的荧光透明物质层（1d） 盘子。 视觉警报指示器包括安装在仪表面板的给定部分的不透明标记（1e），灯壳体（6），开口端以与所述仪表板的后表面相接的方式连接 所述给定部分和安装在所述灯壳体（6）中的电灯（7）。 紫外灯（10）布置在仪表面板的前面，并在其通电时产生紫外线。
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公开(公告)号：US5790322A
公开(公告)日：1998-08-04
申请号：US467478
申请日：1995-06-07
CPC分类号： G01D11/28 , B60K35/00 , G01D7/00 , G02B25/002 , G02B25/008 , G02B3/04 , G02B3/08 , B60K2350/206
摘要： An optical system for magnifying a display panel includes a magnifying lens disposed in front of a display panel. The magnifying lens is constructed with two lenses respectively having convex surfaces opposite each other. At least one of the two convex surfaces is aspherical. A transverse aberration of the magnifying lens is less than the diameter of the pupil of an eye at a point where the eye is positioned. The lens for the optical system is a Fresnel lens whose vortex center is located on its edge. An apparatus for magnifying display panels according to the invention includes an instrument to be viewed distantly and instruments to be viewed not distantly. The instrument to be viewed distantly is disposed distant from the Fresnel lens under a center portion of the Fresnel lens, whereas the instruments to be viewed not distantly are disposed close to the Fresnel lens under an edge portion of the Fresnel lens. An apparatus for magnifying display panels according to the invention includes a display panel illuminating light source disposed inside a housing of the instrument and scale markings provided inside the edge of the opening of the housing.
摘要翻译： 用于放大显示面板的光学系统包括设置在显示面板前方的放大镜。 放大透镜由两个分别具有彼此相对的凸面的透镜构成。 两个凸面中的至少一个是非球面的。 放大镜的横向像差小于眼睛在眼睛所在位置的瞳孔的直径。 用于光学系统的透镜是其涡流中心位于其边缘上的菲涅尔透镜。 根据本发明的用于放大显示面板的装置包括要远距离观察的仪器和不远处的仪器。 在菲涅尔透镜的中心部分设置远离菲涅尔透镜的仪器，而不远处被观察的仪器设置在菲涅尔透镜的边缘部分附近靠近菲涅尔透镜。 根据本发明的用于放大显示面板的装置包括设置在仪器的壳体内的显示面板照明光源和设置在壳体的开口的边缘内的刻度标记。
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公开(公告)号：US5117334A
公开(公告)日：1992-05-26
申请号：US684565
申请日：1991-04-12
申请人： Tsuyoshi Kameda
发明人： Tsuyoshi Kameda
CPC分类号： B60Q3/044 , B60Q3/008 , G01D11/26 , G01D11/28 , Y10S116/26 , Y10S116/36
摘要： An indicator gauge is disclosed, which comprises a meter panel. The meter panel includes a transparent base plate, a transparent colored layer applied to a rear surface of the transparent base plate and a fluorescent transparent substance layer applied to a front surface of the transparent base plate. A visual alarm indicator includes an opaque mark mounted to a given portion of the meter panel, a lamp housing having an open end which is connected to a rear surface of the meter panel in such a manner as to face toward the given portion and an electric lamp installed in the lamp housing. An ultraviolet lamp is arranged in front of the meter panel and generates ultraviolet rays upon electric energization thereof.
摘要翻译： 公开了一种指示器，其包括仪表板（1）。 仪表面板包括透明基板（1a），施加到透明基板（1a）的后表面的透明着色层（1b）和施加到透明基板的前表面的荧光透明物质层（1d） 盘子。 视觉警报指示器包括安装在仪表面板的给定部分的不透明标记（1e），灯壳体（6），开口端以与所述仪表板的后表面相接的方式连接 所述给定部分和安装在所述灯壳体（6）中的电灯（7）。 紫外灯（10）布置在仪表面板的前面，并在其通电时产生紫外线。
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公开(公告)号：US5050527A
公开(公告)日：1991-09-24
申请号：US407312
申请日：1989-09-14
申请人： Tsuyoshi Kameda
发明人： Tsuyoshi Kameda
CPC分类号： G01D13/20 , G01D11/28 , Y10S116/36
摘要： Herein disclosed is an automotive meter which comprises an opaque base plate constructed of one of natural wood and natural stone; graduations provided on a front face of the base plate, the graduations containing a fluorescent material; and an ultraviolet lamp located in front of the base plate.
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公开(公告)号：US06528205B1
公开(公告)日：2003-03-04
申请号：US09719220
申请日：2000-12-11
IPC分类号： H01M216
CPC分类号： H01M2/1606 , H01M2/1666 , H01M2/1673 , H01M2/168
摘要： A separator for sealed cells is provided which attains a high degree of intimate contact with electrode plates, enables the cell to have reduced internal resistance, is less apt to suffer a fatigue phenomenon even upon repetitions of charge/discharge, and improves the life of the cell. Fine rubber particles are adhered to the surface of fibers of a non-woven fabric constituting the separator so that the fine rubber particles are present among the fibers. These fine rubber particles function as elastic bodies to absorb relative positional changes of the fibers and improve the compressive repulsion of the separator.
摘要翻译： 提供了一种用于密封电池的隔膜，其与电极板高度紧密接触，使电池具有降低的内阻，即使在充电/放电重复时也不容易遭受疲劳现象，并且提高了电池的寿命 细胞。 细橡胶颗粒粘附在构成隔膜的无纺织物的纤维表面上，使纤维中存在细小的橡胶颗粒。 这些细小的橡胶颗粒用作弹性体以吸收纤维的相对位置变化并改善隔板的压缩斥力。
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