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19 条记录 (耗时 0.022 秒)

    Method of preparing sodium salts of imidazoledicarboxylic acid substituted cephalosporin derivatives
    5.
    发明授权
    Method of preparing sodium salts of imidazoledicarboxylic acid substituted cephalosporin derivatives 失效
    制备咪唑二羧酸取代头孢菌素衍生物的钠盐的方法

    公开(公告)号：US4423215A

    公开(公告)日：1983-12-27

    申请号：US353809

    申请日：1982-03-02

    申请人： Naohiko Yasuda ,  Hisao Iwagami ,  Yasuo Irie ,  Eiji Nakanishi ,  Hideomi Saito

    发明人： Naohiko Yasuda ,  Hisao Iwagami ,  Yasuo Irie ,  Eiji Nakanishi ,  Hideomi Saito

    IPC分类号： C07D501/04 ,  C07D501/38 ,  C07D501/46

    CPC分类号： C07D501/46

    摘要： A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;and where R is a radical selected from hydrogen, an organic radical such as alkyl, aryl or aralkyl or a heterocyclic group, said organic radical and heterocyclic group being optionally substituted;said method comprising reacting a compound represented by the following formula: ##STR2## with 4-pyridineethanesulfonic acid in an aqueous solution of sodium iodide and subsequently recovering the salt.The compounds are useful in the treatment of bacterial infections, particularly Pseudomonas aeruginosa, in man and other animals.

    摘要翻译： 一种制备由通式（I）＆lt; IMAGE＆gt;表示的取代头孢菌素的咪唑二羧酸衍生物的钠盐的方法，其中X是选自氢，卤素，羟基，烷基，芳基 芳烷氧基，烷氧基，芳氧基，芳烷硫基，芳烷硫基，烷基磺酰基，芳基磺酰基，芳烷基磺酰基，烷基亚磺酰基，芳基亚磺酰基，芳烷基亚磺酰基，氨基，一烷基氨基或二芳基氨基，单或二芳基氨基， ，硝基或杂环基; 并且其中R是选自氢，有机基团如烷基，芳基或芳烷基或杂环基的基团，所述有机基团和杂环基团任选被取代; 所述方法包括将由下式表示的化合物与4-吡啶乙磺酸在碘化钠水溶液中反应，随后回收盐。 这些化合物可用于治疗人和其他动物中细菌感染，特别是铜绿假单胞菌（Pseudomonas aeruginosa）。

    Relaxor ferroelectric solid-solution single crystal, device, and method of using device
    7.
    发明授权
    Relaxor ferroelectric solid-solution single crystal, device, and method of using device 失效
    放电铁电固溶单晶，器件及其使用方法

    公开(公告)号：US07427818B2

    公开(公告)日：2008-09-23

    申请号：US10587543

    申请日：2005-01-28

    申请人： Naohiko Yasuda ,  Hidehiro Ohwa ,  Makoto Iwata

    发明人： Naohiko Yasuda ,  Hidehiro Ohwa ,  Makoto Iwata

    IPC分类号： H01L41/08

    CPC分类号： C30B29/32 ,  G02F1/0027 ,  H01L41/18

    摘要： A relaxor ferroelectric solid solution single crystal is capable of making transitions, at temperatures below the Curie temperature, between a first state which has a high permittivity and blocks optical transmission and a second state which has a low permittivity and allows optical transmission. The relaxor ferroelectric solid solution single crystal undergoes a transition to the second state if an electric field above a threshold is applied thereto in the first state. The relaxor ferroelectric solid solution single crystal undergoes a transition to the first state if heated to or above the Curie temperature in the second state.

    摘要翻译： 弛豫铁电固溶体单晶能够在低于居里温度的温度下在具有高介电常数的第一状态和阻挡光透射之间进行转变，并且能够实现具有低介电常数并允许光透射的第二状态。 如果在第一状态下施加高于阈值的电场，则弛豫铁电固溶体单晶经历向第二状态的转变。 如果在第二状态下加热到或高于居里温度，则弛豫铁电固溶体单晶经历转变到第一状态。

    Method of producing active amino acid esters
    8.
    发明授权
    Method of producing active amino acid esters 失效
    生产活性氨基酸酯的方法

    公开(公告)号：US3984417A

    公开(公告)日：1976-10-05

    申请号：US530495

    申请日：1974-12-09

    申请人： Naohiko Yasuda ,  Yasuo Ariyoshi ,  Koji Toi

    发明人： Naohiko Yasuda ,  Yasuo Ariyoshi ,  Koji Toi

    IPC分类号： A61K38/00 ,  C07D215/26 ,  C07K1/06 ,  C07K1/08 ,  C07K1/10 ,  C07D215/24 ,  C07C101/19 ,  C07C103/52

    CPC分类号： C07C251/00 ,  C07K1/064 ,  C07K1/084 ,  C07K1/10 ,  A61K38/00

    摘要： Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.

    摘要翻译： 如果反应介质含有异腈，具有掩蔽的氨基的氨基酸与具有掩蔽的羧基的氨基酸反应以以良好的产率形成肽衍生物。 异腈还有效地使具有掩蔽氨基的氨基酸与具有活性羟基的化合物缩合成相应的氨基酸酯。 如果反应混合物另外含有具有活性羟基的化合物之一，则提高反应​​的产率。 肽衍生物和具有活性羟基的化合物的氨基酸酯都可用于肽合成。

    Relaxor ferroelectric solid-solution single crystal, device, and method of using device
    9.
    发明申请
    Relaxor ferroelectric solid-solution single crystal, device, and method of using device 失效
    放电铁电固溶单晶，器件及其使用方法

    公开(公告)号：US20070152182A1

    公开(公告)日：2007-07-05

    申请号：US10587543

    申请日：2005-01-28

    申请人： Naohiko Yasuda ,  Hidehiro Ohwa ,  Makotgo Iwata

    发明人： Naohiko Yasuda ,  Hidehiro Ohwa ,  Makotgo Iwata

    IPC分类号： C04B35/00

    CPC分类号： C30B29/32 ,  G02F1/0027 ,  H01L41/18

    摘要： A relaxor ferroelectric solid solution single crystal is capable of making transitions, at temperatures below the Curie temperature, between a first state which has a high permittivity and blocks optical transmission and a second state which has a low permittivity and allows optical transmission. The relaxor ferroelectric solid solution single crystal undergoes a transition to the second state if an electric field above a threshold is applied thereto in the first state. The relaxor ferroelectric solid solution single crystal undergoes a transition to the first state if heated to or above the Curie temperature in the second state.

    摘要翻译： 弛豫铁电固溶体单晶能够在低于居里温度的温度下在具有高介电常数的第一状态和阻挡光透射之间进行转变，并且能够实现具有低介电常数并允许光透射的第二状态。 如果在第一状态下施加高于阈值的电场，则弛豫铁电固溶体单晶经历向第二状态的转变。 如果在第二状态下加热到或高于居里温度，则弛豫铁电固溶体单晶经历转变到第一状态。

    4-Methylsulfonyl-azetidinone derivatives
    10.
    发明授权
    4-Methylsulfonyl-azetidinone derivatives 失效
    4-甲基磺酰基 - 氮杂环丁酮衍生物

    公开(公告)号：US4537719A

    公开(公告)日：1985-08-27

    申请号：US431557

    申请日：1982-09-30

    申请人： Toshihisa Kato ,  Hisao Iwagami ,  Naohiko Yasuda

    发明人： Toshihisa Kato ,  Hisao Iwagami ,  Naohiko Yasuda

    IPC分类号： C07D205/08 ,  A61K31/395 ,  A61K31/397 ,  A61P31/04 ,  C07D205/09 ,  C07D205/095 ,  C07D403/12 ,  A61K31/495

    CPC分类号： C07D403/12 ,  C07D205/09 ,  C07D205/095

    摘要： The present invention relates to novel azetidinone derivatives of the general formula: ##STR1## where n is 0 or 2,X is hydrogen, halogen, amino, alkylamino, benzylamino or acylamino, andY is ##STR2## R is lower alkyl, 2,2,2-trichloroethyl, or aralkyl; and M is hydrogen or alkali metal having .beta.-lactamase inhibiting activity.The derivatives of the present invention can be administered together with antibiotics having a .beta.-lactam ring as antibacterial agents against .beta.-lactamase producing bacteria.A method for synthesizing said azetidinone derivatives is also disclosed.

    摘要翻译： 本发明涉及以下通式的新的氮杂环丁酮衍生物：其中n为0或2，X为氢，卤素，氨基，烷基氨基，苄基氨基或酰基氨基，Y为低级烷基， 2,2-三氯乙基或芳烷基; M是具有β-内酰胺酶抑制活性的氢或碱金属。 本发明的衍生物可以与具有β-内酰胺环的抗生素一起作为产生β-内酰胺酶的细菌的抗菌剂一起施用。 还公开了合成所述氮杂环丁酮衍生物的方法。