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公开(公告)号：US20240044841A1
公开(公告)日：2024-02-08
申请号：US18259012
申请日：2021-12-23
申请人： Micromass UK Limited
发明人： Jakub Ujma , David Langridge , Jason Wildgoose , Keith Richardson , Kevin Giles
IPC分类号： G01N27/623
CPC分类号： G01N27/623
摘要： A method of analysing high-mass (>1 MDa) particles comprises ionising particles to as to produce ions, separating the ions according to mass to charge ratio by passing the ions through an ion separation device in which one or more time-varying electric fields is used to urge ions through a gas such that ions are separated according to mass to charge ratio, measuring the transit time of the ions through the ion separation device, and determining a drift time or mass to charge ratio distribution of the ions therefrom. The method further comprises identifying one or more charge envelopes in the drift time or mass to charge ratio distribution, and using the one or more charge envelopes to characterise the particles.
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公开(公告)号：US20200075308A1
公开(公告)日：2020-03-05
申请号：US16563203
申请日：2019-09-06
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
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公开(公告)号：US20180174817A1
公开(公告)日：2018-06-21
申请号：US15578053
申请日：2016-05-31
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
CPC分类号： H01J49/4215 , H01J49/063 , H01J49/067 , H01J49/4255
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
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公开(公告)号：US20240047191A1
公开(公告)日：2024-02-08
申请号：US18259015
申请日：2021-12-23
申请人： Micromass UK Limited
发明人： Jason Wildgoose , Martin Green , David Langridge , Kevin Giles , Jakub Ujma
IPC分类号： H01J49/40 , G01N27/623 , H01J49/02 , H01J49/00
CPC分类号： H01J49/403 , G01N27/623 , H01J49/025 , H01J49/005
摘要： A method of analysing ions comprises separating ions according to a first physico-chemical property by passing the ions through an ion separation device, and measuring the transit time of an ion through the ion separation device. The method further comprises detecting the ion using a charge-resolving ion detector so as to determine the charge of the ion, and using the transit time and the charge of the ion to determine a second physico-chemical property of the ion.
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公开(公告)号：US10832900B2
公开(公告)日：2020-11-10
申请号：US16563203
申请日：2019-09-06
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
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公开(公告)号：US20210082680A1
公开(公告)日：2021-03-18
申请号：US16970252
申请日：2019-02-15
申请人： Micromass UK Limited
发明人： Gordon David , David Langridge , Martin Raymond Green , Richard Moulds , Daniel J. Kenny , Kenneth Worthington
IPC分类号： H01J49/42
摘要： A method of operating a quadrupole device is disclosed. The method comprises operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device, and operating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device. In the first mode of operation, the quadrupole device is operated in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or in a first X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. In the second mode of operation, the quadrupole device is operated in a second X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device.
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公开(公告)号：US20210082679A1
公开(公告)日：2021-03-18
申请号：US16970220
申请日：2019-02-15
申请人： Micromass UK Limited
摘要： A method of operating a quadrupole device is disclosed. The method comprises applying a main drive voltage to the quadrupole device and applying three or more auxiliary drive voltages to the quadrupole device. The three or more auxiliary drive voltages correspond to two or more pairs of X-band or Y-band auxiliary drive voltages.
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公开(公告)号：US10453667B2
公开(公告)日：2019-10-22
申请号：US15578053
申请日：2016-05-31
申请人： Micromass UK Limited
发明人： Martin Green , Jason Wildgoose , Keith Richardson , Kevin Giles , Daniel Kenny , David Langridge , Richard Moulds
摘要： A mass filter is disclosed having at least one electrode (42-48) comprising an aperture (43) or recess. Voltages are applied to the electrodes (42-48) of the mass filter such that ions having mass to charge ratios in a desired range are confined by the electrodes and are transmitted along and through the mass filter, whereas ions (47,49) having mass to charge ratios outside of said desired range are unstable and pass into the aperture (43) or recess such that they are filtered out by the mass filter. The aperture (43) or recess reduces or eliminates the number of ions that would otherwise impact the electrode surface facing the ion transmission axis and hence reduces degradation of the ion transmission properties of the mass filter.
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公开(公告)号：US11361958B2
公开(公告)日：2022-06-14
申请号：US16970252
申请日：2019-02-15
申请人： Micromass UK Limited
发明人： David Gordon , David Langridge , Martin Raymond Green , Richard Moulds , Daniel J. Kenny , Kenneth Worthington
摘要： A method of operating a quadrupole device is disclosed. The method comprises operating the quadrupole device in a first mode of operation, wherein ions within a first mass to charge ratio range are selected and/or transmitted by the quadrupole device, and operating the quadrupole device in a second mode of operation, wherein ions within a second different mass to charge ratio range are selected and/or transmitted by the quadrupole device. In the first mode of operation, the quadrupole device is operated in a normal mode of operation wherein a main drive voltage is applied to the quadrupole device, or in a first X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device. In the second mode of operation, the quadrupole device is operated in a second X-band or Y-band mode of operation wherein a main drive voltage and two or more auxiliary drive voltages are applied to the quadrupole device.
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公开(公告)号：US11282693B2
公开(公告)日：2022-03-22
申请号：US16970220
申请日：2019-02-15
申请人： Micromass UK Limited
摘要： A method of operating a quadrupole device is disclosed. The method comprises applying a main drive voltage to the quadrupole device and applying three or more auxiliary drive voltages to the quadrupole device. The three or more auxiliary drive voltages correspond to two or more pairs of X-band or Y-band auxiliary drive voltages.
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