公开(公告)号：US08396548B2

公开(公告)日：2013-03-12

申请号：US12616720

申请日：2009-11-11

申请人： Mike Perry ,  Corbett W. Stone ,  Rolfe Tyson Gustus ,  Ronda Schreiber ,  Meital Mazor ,  Brian Conn

发明人： Mike Perry ,  Corbett W. Stone ,  Rolfe Tyson Gustus ,  Ronda Schreiber ,  Meital Mazor ,  Brian Conn

IPC分类号： A61M25/10

CPC分类号： A61M25/10 ,  A61B5/053 ,  A61B5/6853 ,  A61B18/1492 ,  A61B18/24 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00898 ,  A61B2018/1861 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/45 ,  A61L2300/606 ,  A61M25/104 ,  A61M37/0092 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61N7/022

摘要： Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.

摘要翻译： 公开了用于通过涂层或流体递送通道在腔中选择性药物或流体递送的方法和系统。 一个系统包括细长导管，其具有近端和远端，其间具有轴线，导管具有靠近远端的径向可扩张的气囊，靠近球囊的能量传递部分用于传递能量;热可变涂层，具有可释放的 联接到气囊的药物，当可膨胀气囊膨胀时，热可变涂层被定向为抵靠身体组织，并且能量源可操作地联接到能量输送部分，其被配置为激发能量输送部分以加热和液化热变性涂层 将药物释放到身体组织。

公开(公告)号：US20100125239A1

公开(公告)日：2010-05-20

申请号：US12616720

申请日：2009-11-11

申请人： Mike Perry ,  Corbett W. Stone ,  Rolfe Tyson Gustus ,  Ronda Schreiber ,  Meital Mazor ,  Brian Conn

发明人： Mike Perry ,  Corbett W. Stone ,  Rolfe Tyson Gustus ,  Ronda Schreiber ,  Meital Mazor ,  Brian Conn

IPC分类号： A61M25/10 ,  A61N1/30

CPC分类号： A61M25/10 ,  A61B5/053 ,  A61B5/6853 ,  A61B18/1492 ,  A61B18/24 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00898 ,  A61B2018/1861 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L2300/45 ,  A61L2300/606 ,  A61M25/104 ,  A61M37/0092 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/1088 ,  A61N7/022

摘要： Methods and systems are disclosed for selective drug or fluid delivery in a lumen through a coating or fluid delivery channels. One system includes an elongate catheter having a proximal end and a distal end with an axis therebetween, the catheter having a radially expandable balloon near the distal end and an energy delivery portion proximate the balloon for transmission of energy, a thermally changeable coating having a releasable drug coupled to the balloon, the thermally changeable coating being oriented to be urged against the body tissue when the expandable balloon expands and an energy source operatively coupled to the energy delivery portion configured to energize the energy delivery portion to heat and liquefy the thermally changeable coating to release the drug to the body tissue.

摘要翻译： 公开了用于通过涂层或流体输送通道在腔中选择性药物或流体递送的方法和系统。 一个系统包括细长导管，其具有近端和远端，其间具有轴线，导管具有靠近远端的径向可扩张的气囊，靠近球囊的能量传递部分用于传递能量;热可变涂层，具有可释放的 联接到气囊的药物，当可膨胀气囊膨胀时，热可变涂层被定向为抵靠身体组织，并且能量源可操作地联接到能量输送部分，其被配置为激发能量输送部分以加热和液化热变性涂层 将药物释放到身体组织。

公开(公告)号：US20100076299A1

公开(公告)日：2010-03-25

申请号：US12564268

申请日：2009-09-22

申请人： Rolfe Tyson Gustus ,  Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Meital Mazor ,  Linas R. Kunstmanas

发明人： Rolfe Tyson Gustus ,  Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Meital Mazor ,  Linas R. Kunstmanas

IPC分类号： A61N7/02 ,  A61B18/20 ,  A61B18/24 ,  A61B18/18 ,  A61B6/00 ,  A61B5/055

CPC分类号： A61B18/245 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/055 ,  A61B8/12 ,  A61B17/2202 ,  A61B18/18 ,  A61B2017/00057 ,  A61B2018/00642 ,  A61B2018/2272 ,  A61B2090/374 ,  A61N7/022 ,  A61N2007/0078

摘要： A system for inducing desirable temperature effects on body tissue, the body tissue being disposed about a lumen. The system includes an elongate catheter having a proximal end and a distal end with an axis therebetween with an energy delivery portion for transmission of energy. A tissue analyzer configured to characterize the body tissue in the lumen proximate the energy delivery portion and an energy source coupled to the energy delivery portion transmitting tissue treatment energy, wherein the energy is non-RF energy. A processor coupled to the tissue analyzer and energy source, the processor configured to determine an appropriate treatment energy for the characterized body tissue so as to mildly heat the body tissue with the energy delivery portion without ablating.

摘要翻译： 一种用于在身体组织上诱导期望的温度效应的系统，所述身体组织围绕内腔设置。 该系统包括细长导管，其具有近端和远端，其间具有用于传输能量的能量传递部分的轴线。 组织分析器，被配置为表征靠近能量传递部分的内腔中的身体组织，以及耦合到传送组织处理能量的能量传递部分的能量源，其中能量是非RF能量。 耦合到组织分析器和能量源的处理器，所述处理器被配置为确定所述特征的身体组织的适当的治疗能量，以便在不消融的情况下用能量输送部分轻度地加热身体组织。

公开(公告)号：US10213252B2

公开(公告)日：2019-02-26

申请号：US13385540

申请日：2012-02-24

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R. Kunstmanas

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R. Kunstmanas

IPC分类号： A61B18/14 ,  A61B18/00

摘要： Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

公开(公告)号：US09125667B2

公开(公告)日：2015-09-08

申请号：US11975383

申请日：2007-10-18

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Rolfe Tyson Gustus

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Rolfe Tyson Gustus

IPC分类号： A61B18/14 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00702 ,  A61B2018/00875

摘要： A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands.

摘要翻译： 导管和导管系统可用于通过温和加热结合轻度或标准扩张来治疗疾病组织。 当结构膨胀时，具有多个电极的具有径向可膨胀气囊的细长柔性导管主体接合包括患病组织的组织。

公开(公告)号：US20120158101A1

公开(公告)日：2012-06-21

申请号：US13385555

申请日：2012-02-24

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Rolfe Tyson Gustus

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Rolfe Tyson Gustus

IPC分类号： A61F7/12 ,  A61N5/00

CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00702 ,  A61B2018/00875 ,  A61F7/12 ,  A61F7/123 ,  A61F2007/126

摘要： A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands.

摘要翻译： 导管和导管系统可用于通过温和加热结合轻度或标准扩张来治疗疾病组织。 当结构膨胀时，具有多个电极的具有径向可膨胀气囊的细长柔性导管主体接合包括患病组织的组织。

公开(公告)号：US20120157986A1

公开(公告)日：2012-06-21

申请号：US13385540

申请日：2012-02-24

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R. Kunstmanas

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R. Kunstmanas

IPC分类号： A61B18/14 ,  A61B18/18

CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/1467

摘要： Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

摘要翻译： 公开了通过温和加热来治疗患病组织的方法和系统。 该方法在围绕具有健康组织和患病组织的内腔的组织上引起血管舒张。 该方法包括将探针表面耦合到目标位置处的管腔组织，并将期望量的组织重塑能量从耦合的探针传输到管腔组织中的多个离散重建区域中的每一个中，使得组织重塑能量加热多个 重建区域，重塑能量被配置为避免肌肉收缩并抑制管腔的急性和长期闭塞。

公开(公告)号：US10413356B2

公开(公告)日：2019-09-17

申请号：US13385555

申请日：2012-02-24

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Rolfe Tyson Gustus

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Arthur G. Blanck ,  Len Briggs ,  Mike Perry ,  Rolfe Tyson Gustus

IPC分类号： A61B18/14 ,  A61F7/12 ,  A61B18/00

摘要： A catheter and catheter system may be used to treat disease tissue by gentle heating in combination with gentle or standard dilation. An elongate flexible catheter body with a radially expandable balloon having a plurality of electrodes engage tissue including diseased tissue when the structure expands.

公开(公告)号：US09974607B2

公开(公告)日：2018-05-22

申请号：US11975474

申请日：2007-10-18

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R Kunstmanas

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R Kunstmanas

IPC分类号： A61B18/14 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/1467

摘要： Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

公开(公告)号：US20080188913A1

公开(公告)日：2008-08-07

申请号：US11975474

申请日：2007-10-18

申请人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R. Kunstmanas

发明人： Corbett W. Stone ,  Michael F. Hoey ,  Rolfe Tyson Gustus ,  Mike Perry ,  Arthur G. Blanck ,  Linas R. Kunstmanas

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/1467

摘要： Methods and systems are disclosed for treating diseased tissue by gentle heating. The method induces vasodilation on tissue disposed about an lumen having both healthy tissue and diseased tissue. The method includes coupling a probe surface to the luminal tissue at a target location and transmitting desired quantities of tissue remodeling energy from the coupled probe into each of a plurality of discrete remodeling zones in the luminal tissue so that the tissue remodeling energy heats the plurality of remodeling zones, the remodeling energy being configured to avoid muscular contraction and inhibit both acute and long-term occlusion of the lumen.

摘要翻译： 公开了通过温和加热来治疗患病组织的方法和系统。 该方法在围绕具有健康组织和患病组织的内腔的组织上引起血管舒张。 该方法包括将探针表面耦合到目标位置处的管腔组织，并将期望量的组织重塑能量从耦合的探针传输到管腔组织中的多个离散重建区域中的每一个中，使得组织重塑能量加热多个 重建区域，重塑能量被配置为避免肌肉收缩并抑制管腔的急性和长期闭塞。