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1.发明申请Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same 有权用于基于聚合伯胺的膜离子交换色谱的介质，含有该介质的吸附装置和使用其的色谱方案和纯化方法公开(公告)号：US20090050566A1
公开(公告)日：2009-02-26
申请号：US12221496
申请日：2008-08-04
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合生物样品中的宿主细胞蛋白质和其他杂质。
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2.发明申请公开(公告)号：US20110288277A1
公开(公告)日：2011-11-24
申请号：US13167297
申请日：2011-06-23
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合生物样品中的宿主细胞蛋白质和其他杂质。
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3.发明授权Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same 有权用于基于聚合伯胺的膜离子交换色谱的介质，含有该介质的吸附装置和使用其的色谱方案和纯化方法公开(公告)号：US08435406B2
公开(公告)日：2013-05-07
申请号：US13363397
申请日：2012-02-01
IPC分类号： B01D15/08
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合宿主细胞蛋白质和其他杂质。
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公开(公告)号：US20110284446A1
公开(公告)日：2011-11-24
申请号：US13167291
申请日：2011-06-23
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
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5.发明申请公开(公告)号：US20120193278A1
公开(公告)日：2012-08-02
申请号：US13363397
申请日：2012-02-01
IPC分类号： B01D15/10
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合宿主细胞蛋白质和其他杂质。
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6.发明申请Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same 审中-公开基于聚合一级胺的膜离子交换色谱介质，含有该介质的吸附装置和色谱方案及使用其的纯化方法公开(公告)号：US20120121819A1
公开(公告)日：2012-05-17
申请号：US13339503
申请日：2011-12-29
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (e.g., Protein A or Protein G) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方案和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G）和任选的一种或多种抛光装置如阳离子交换柱的下游。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合生物样品中的宿主细胞蛋白质和其他杂质。
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7.发明授权Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same 有权用于基于聚合伯胺的膜离子交换色谱的介质，含有该介质的吸附装置和使用其的色谱方案和纯化方法公开(公告)号：US08137561B2
公开(公告)日：2012-03-20
申请号：US13167297
申请日：2011-06-23
IPC分类号： B01D15/08
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合生物样品中的宿主细胞蛋白质和其他杂质。
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公开(公告)号：US09433922B2
公开(公告)日：2016-09-06
申请号：US12221496
申请日：2008-08-04
IPC分类号： B01J20/282 , B01D15/36 , B01D15/38 , B01D15/32 , B01J47/12 , B01J20/28 , B01D15/18 , B01J20/32
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
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9.发明申请Media For Membrane Ion Exchange Chromatography Based On Polymeric Primary Amines, Sorption Device Containing That Media, And Chromatography Scheme And Purification Method Using The Same 审中-公开基于聚合一级胺的膜离子交换色谱介质，含有该介质的吸附装置和色谱方案及使用其的纯化方法公开(公告)号：US20100200507A1
公开(公告)日：2010-08-12
申请号：US12764340
申请日：2010-04-21
IPC分类号： B01D15/08
CPC分类号： B01J20/28033 , B01D15/1871 , B01D15/362 , B01D15/363 , B01D15/3804 , B01J20/3282 , B01J47/12 , Y10T428/249987
摘要： Media and devices, such as anion exchangers including such media, wherein the media is a membrane having a surface coated with a polymer such as a polyallylamine. The resulting membrane offers stronger binding of protein impurities and superior removal of host cell proteins from biological samples than conventional ligands based on quaternary ammonium salts, including trimethylammonium ligands. Also described is a chromatography scheme and method for purifying monoclonal antibodies, wherein the anion exchange sorber is placed downstream of an affinity column (such as Protein A or Protein G affinity column) and optionally one or more polishing devices such as cationic exchange columns. Little or no dilution of the cation exchanger pool (or affinity column exchange pool where no cation exchanger is used) is necessary to lower the conductivity of the sample. The sorber functions well to strongly bind host cell proteins and other impurities in biological samples even at high conductivities and pH.
摘要翻译： 介质和装置，例如包括这种介质的阴离子交换剂，其中介质是具有涂覆聚合物如聚烯丙基胺的表面的膜。 与基于季铵盐（包括三甲基铵配体）的常规配体相比，所得到的膜提供了更强的蛋白质杂质结合和优于宿主细胞蛋白质从生物样品中的去除。 还描述了用于纯化单克隆抗体的色谱方法和方法，其中阴离子交换吸附剂置于亲和柱（例如蛋白A或蛋白G亲和柱）的下游，以及任选的一种或多种抛光装置如阳离子交换柱。 阳离子交换池（或不使用阳离子交换剂的亲和柱交换池）的稀释很少或不需要，以降低样品的电导率。 即使在高电导率和pH下，吸附剂也能很好地结合生物样品中的宿主细胞蛋白质和其他杂质。
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公开(公告)号：US08228029B2
公开(公告)日：2012-07-24
申请号：US12035894
申请日：2008-02-22
IPC分类号： H02J7/00
CPC分类号： H01M2/1066
摘要： An electrical combination includes a power tool having a body, a motor supported by the body, a support portion, and a drive mechanism driven by the motor such that the drive mechanism is operable to drive a tool element. The electrical combination also includes a battery operable for coupling to the power tool via the support portion. The battery is electrically connectable with the motor to selectively supply power to the motor. A single latch is positioned on the support portion of the power tool. The single latch is moveable between a locked position to secure the battery to the power tool and an unlocked position to allow removal of the battery from the support portion of the power tool.
摘要翻译： 电气组合包括具有主体的电动工具，由主体支撑的电动机，支撑部分和由电动机驱动的驱动机构，使得驱动机构可操作以驱动工具元件。 电气组合还包括可操作以经由支撑部分耦合到电动工具的电池。 电池可与电机电连接以选择性地向电动机供电。 单个闩锁定位在电动工具的支撑部分上。 单个闩锁可以在将电池固定到电动工具的锁定位置和解锁位置之间移动，以允许电池从电动工具的支撑部分移除。
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