公开(公告)号：US20090215893A1

公开(公告)日：2009-08-27

申请号：US11920848

申请日：2006-05-09

申请人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Maki Kaneko ,  Toshii Iida ,  Shinji Inomata

发明人： Mikiko Kaminuma ,  Masaru Suetsugu ,  Maki Kaneko ,  Toshii Iida ,  Shinji Inomata

IPC分类号： A61K31/19

CPC分类号： A61K8/0212 ,  A61K8/44 ,  A61K8/46 ,  A61Q1/02 ,  A61Q19/00

摘要： The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and to further provide an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor agent, pore-shrinking agent, or rough skin preventing/amaliorating agent comprises one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof. The external composition for skin comprises the one, two, or more compounds selected from the group consisting of α-amino acid derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/amaliorating agent.

摘要翻译： 本发明提供了具有角化不全抑制，孔收缩或粗糙皮肤抑制/消瘦等功能的角化不全抑制剂，孔收缩剂或粗糙皮肤防止/缓解剂，不会引起感觉刺激等安全性问题，而且 并且为了进一步提供添加了具有上述功能的化合物的皮肤的外用组合物。 角化不全抑制剂，孔收缩剂或粗糙皮肤防止/改善剂包含一种，两种或更多种选自α-氨基酸衍生物及其盐的化合物。 用于皮肤的外用组合物包含一种，两种或更多种选自上述角化不力抑制剂的α-氨基酸衍生物及其盐，孔收缩剂或粗糙皮肤防止/减量剂的化合物。

公开(公告)号：US20110004019A1

公开(公告)日：2011-01-06

申请号：US12921866

申请日：2009-03-12

申请人： Toshii Iida ,  Maki Kaneko ,  Mikiko Kaminuma ,  Masaru Suetsugu

发明人： Toshii Iida ,  Maki Kaneko ,  Mikiko Kaminuma ,  Masaru Suetsugu

IPC分类号： C07C233/01 ,  C07C233/47

CPC分类号： A61Q19/007 ,  A61K8/0212 ,  A61K8/44 ,  A61K8/442 ,  A61K31/16 ,  A61K31/185 ,  A61K31/195 ,  A61K31/198 ,  A61Q1/02 ,  A61Q1/12

摘要： The present invention provides a parakeratosis inhibitor, a pore-shrinking agent, and a rough skin inhibiting or ameliorating agent comprising, as an active ingredient, a compound that has excellent effects and high safety without safety problems such as sensory irritation, and provides an external composition for skin containing the same. The compound is selected from the glutamic acid derivatives represented by formula (1) or (2) and the salts thereof: wherein A represents a carbamoyl group, a benzyloxycarbonyl group, an alkyl group having 1 to 3 carbon atoms, an allyl group, or an amidino group; wherein Z represents an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, etc.; Y represents OH, an alkyloxy group having 1 to 3 carbon atoms, an allyloxy group, or NR3R4; R1 to R4 each independently represents H, an alkyl group having 1 to 3 carbon atoms, an allyl group, a cycloalkyl group having 3 to 7 carbon atoms, a cycloalkenyl group having 3 to 7 carbon atoms, a phenyl group, or a benzyl group, or R1 and R2, or R3 and R4, independently form a heterocycle.

摘要翻译： 本发明提供一种角化不全抑制剂，孔收缩剂和粗皮肤抑制或改善剂，其包含具有优异效果和高安全性的化合物作为活性成分，没有诸如感觉刺激之类的安全问题，并且提供外部 含有相同成分的皮肤。 该化合物选自由式（1）或（2）表示的谷氨酸衍生物及其盐：其中A表示氨基甲酰基，苄氧基羰基，具有1至3个碳原子的烷基，烯丙基或 脒基; 其中Z表示碳原子数1〜4的烷基，碳原子数2〜4的烯基等。 Y表示OH，具有1至3个碳原子的烷氧基，烯丙氧基或NR 3 R 4; R 1〜R 4各自独立地表示H，碳原子数1〜3的烷基，烯丙基，碳原子数3〜7的环烷基，碳原子数3〜7的环烯基，苯基或苄基 ，或R 1和R 2，或R 3和R 4独立地形成杂环。

公开(公告)号：US20120283302A1

公开(公告)日：2012-11-08

申请号：US13266663

申请日：2010-04-28

申请人： Maki Kaneko ,  Takuya Hiruma ,  Masaru Suetsugu ,  Chika Katagiri ,  Toshii Iida ,  Tomoko Onodera

发明人： Maki Kaneko ,  Takuya Hiruma ,  Masaru Suetsugu ,  Chika Katagiri ,  Toshii Iida ,  Tomoko Onodera

IPC分类号： A61K31/4166 ,  A61K31/17 ,  A61P35/00 ,  A61P19/04 ,  A61P17/08 ,  A61P17/12 ,  A61P17/06 ,  A61K31/4015 ,  A61P17/00

CPC分类号： A61K31/17 ,  A61K31/4015 ,  A61K31/4166 ,  C07D207/27 ,  C07D233/34 ,  C07D233/40

摘要： A SCCA-1 production inhibitor, comprising as an active ingredient, at least one carboxamide derivative selected from the group consisting of compounds represented by the following formula (I): wherein X is CR5 or N, R1, R4 and R5 each independently represent hydrogen, C1-C4 alkyl or a C1-C6 hydroxyalkyl group having 1-5 hydroxy groups, R2 and R3 each independently represent hydrogen, C1-C4 alkyl or a C1-C6 hydroxyalkyl group having 1-5 hydroxy groups, or each represents a group —(CH2)n—, wherein n represents an integer of 1 or 2, and may form a 5- to 6-membered ring together with the atoms to which they are bonded and with the carbonyl group, allantoin, and salts thereof.

摘要翻译： 一种SCCA-1生产抑制剂，其包含作为活性成分的至少一种选自由下式（I）表示的化合物的羧酰胺衍生物：其中X为CR 5或N，R 1，R 4和R 5各自独立地表示氢 C1-C4烷基或具有1-5个羟基的C1-C6羟基烷基，R2和R3各自独立地表示氢，C1-C4烷基或具有1-5个羟基的C1-C6羟烷基，或各自表示基团 - （CH 2）n - ，其中n表示1或2的整数，并且可以与它们所键合的原子和羰基，尿囊素及其盐一起形成5-至6-元环。

公开(公告)号：US06884615B2

公开(公告)日：2005-04-26

申请号：US10614963

申请日：2003-07-08

申请人： Hideyuki Suzuki ,  Yoshikatu Sekine ,  Hisao Kuramoto ,  Maki Kaneko

发明人： Hideyuki Suzuki ,  Yoshikatu Sekine ,  Hisao Kuramoto ,  Maki Kaneko

IPC分类号： G01N37/00 ,  B01L3/00 ,  C12M1/00 ,  C12M1/34

CPC分类号： B01L3/5085 ,  B01L9/50 ,  Y10S436/809

摘要： A microplate having a base and wells is disclosed. The base has mark parts at least on one edge thereof. Each mark part is defined by notches cut in the edge of the base. The wells are provided in the base and arranged in rows and columns. The mark parts can be used as indicia for identifying not only the microplate but also the wells so that the microplate and the wells can be easily identified without writing numerals or marks on the edges of the base with a felt pen or the like.

摘要翻译： 公开了具有碱和微孔的微孔板。 基座至少在其一个边缘上具有标记部件。 每个标记部分由在基部边缘切割的切口限定。 井被设置在基座中并排列成行和列。 标记部分可以用作不仅用于识别微孔板，而且用于识别孔的标记，使得微孔板和孔可以容易地识别，而不用毡笔等在基部的边缘上书写数字或标记。