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公开(公告)号：US20090215850A1
公开(公告)日：2009-08-27
申请号：US12038033
申请日：2008-02-27
IPC分类号： A61K31/416 , C07D231/54 , A61P25/00 , A61P19/02
CPC分类号： A61K31/416 , C07D231/54
摘要： The present invention is directed to a method for treating, ameliorating or preventing CB2 receptor mediated pain in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I): or a form thereof, wherein X1R1, X2R2, X3R3, X4R4 and X5R5 are as defined herein.
摘要翻译： 本发明涉及在有需要的受试者中治疗，改善或预防CB2受体介导的疼痛的方法，其包括向受试者施用有效量的式（I）化合物或其形式，其中X1R1，X2R2 X3R3，X4R4和X5R5如本文所定义。
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公开(公告)号：US20080234347A1
公开(公告)日：2008-09-25
申请号：US12038029
申请日：2008-02-27
IPC分类号： A61K31/416 , A61P29/00
CPC分类号： A61K31/415 , A61K31/416
摘要： The present invention is directed to a method for treating, ameliorating or preventing CB2 receptor mediated pain in a subject in need thereof comprising administering to the subject an effective amount of a compound of formula (I): or a form thereof, wherein X1R1, X2R2, X3R3, X4R4 and X5R5 are as defined herein.
摘要翻译： 本发明涉及一种用于治疗，改善或预防有需要的受试者的CB2受体介导的疼痛的方法，其包括向所述受试者施用有效量的式（I）化合物或其形式，其中X
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公开(公告)号：US08242157B2
公开(公告)日：2012-08-14
申请号：US12797743
申请日：2010-06-10
申请人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号： C07D401/00 , C07D235/12 , C07D235/22 , A01N43/52 , A61K31/415
CPC分类号： C07D235/30 , C07D498/06
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R 0，R 1，R 2，R 3，R 4和a在本文中定义。
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公开(公告)号：US08450497B2
公开(公告)日：2013-05-28
申请号：US12797712
申请日：2010-06-10
申请人： Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人： Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号： C07D413/00
CPC分类号： A61K31/5383 , A61K31/4184 , C07D233/52 , C07D235/30 , C07D498/06
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
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公开(公告)号：US20110003801A1
公开(公告)日：2011-01-06
申请号：US12797743
申请日：2010-06-10
申请人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号： A61K31/5383 , C07D235/30 , C07D498/06 , A61K31/4184 , A61P9/12 , A61P9/00 , A61P25/04 , A61P29/00
CPC分类号： C07D235/30 , C07D498/06
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R 0，R 1，R 2，R 3，R 4和a在本文中定义。
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公开(公告)号：US07825151B2
公开(公告)日：2010-11-02
申请号：US11688589
申请日：2007-03-20
申请人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
发明人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54 , C07D403/12
摘要： This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
摘要翻译： 本发明涉及式（I）的六氢 - 环辛基吡唑大麻素调节剂化合物：以及用于治疗，改善或预防大麻素受体介导的综合征，病症或疾病的方法。
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![Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators](/abs-image/US/2013/12/31/US08618150B2/abs.jpg.150x150.jpg)
公开(公告)号：US08618150B2
公开(公告)日：2013-12-31
申请号：US13316031
申请日：2011-12-09
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D471/04 , A61K31/415 , C07D235/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，并且在本文中定义。
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公开(公告)号：US08378117B2
公开(公告)日：2013-02-19
申请号：US11688552
申请日：2007-03-20
申请人： Fina Liotta , Mingde Xia , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
发明人： Fina Liotta , Mingde Xia , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
IPC分类号： C07D231/54
CPC分类号： C07D231/54 , C07D403/04
摘要： This invention is directed to a hexahydro-cycloheptapyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
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![IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS](/abs-image/US/2012/06/14/US20120149699A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120149699A1
公开(公告)日：2012-06-14
申请号：US13316031
申请日：2011-12-09
IPC分类号： A61K31/5377 , A61P25/02 , A61P25/00 , A61P25/04 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/415 , C07D235/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，并且在本文中定义。
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公开(公告)号：US20100317633A1
公开(公告)日：2010-12-16
申请号：US12868812
申请日：2010-08-26
申请人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
发明人： Mingde Xia , Fina Liotta , Huajun Lu , Meng Pan , Michael P. Wachter , Mark J. Macielag
IPC分类号： A61K31/56 , A61K31/416 , A61K31/55 , A61K31/53 , A61K31/4166 , A61K31/57 , A61K31/519 , A61P15/18 , A61P25/08
CPC分类号： C07D231/54 , C07D403/12
摘要： This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or disease.
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