公开(公告)号：US10743593B2

公开(公告)日：2020-08-18

申请号：US15843386

申请日：2017-12-15

申请人： Miroslav Rybak

发明人： Miroslav Rybak

IPC分类号： A41D3/00 ,  A41D27/04 ,  A41D27/10 ,  A42B1/04 ,  A41B7/00

摘要： The present application provides a garment that includes: a hood, the hood having an opening at a front of the hood, the opening extending between a bottom and top of the hood; at least a first passageway meandering in a concave shape on at least one side of the hood and extending from the bottom front of the hood, rearward over a wearer's shoulder, transitioning vertically toward the top of the hood, and continuing at the top of the hood forward back over the wearer's shoulder toward the front of the hood; and at least way drawstring disposed within the first passageway.

公开(公告)号：US5858357A

公开(公告)日：1999-01-12

申请号：US649184

申请日：1996-05-17

申请人： Frantisek Trnka ,  Miroslav Rybak ,  Roman Marek ,  Ladislav Vavra

发明人： Frantisek Trnka ,  Miroslav Rybak ,  Roman Marek ,  Ladislav Vavra

IPC分类号： A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61K38/54 ,  C12N9/26 ,  C12N9/76

CPC分类号： A61K38/47 ,  A61K38/4826 ,  A61K38/4853 ,  A61K38/486 ,  A61K38/57

摘要： The invention is directed to a pharmaceutical preparation with a modulatory effect on malignant tumors, which contains a combination of protease proenzymes and amylases in a ratio between 1:100 and 100:1 in enzymatic activity units, and a protease inhibitor. The invention is also directed to use of such a preparation to modulate the effects of malignant tumors in humans and animals.

摘要翻译： 本发明涉及对恶性肿瘤具有调节作用的药物制剂，其含有蛋白酶原酶和酶活性单位之间1:100至100:1之间的蛋白酶原酶和淀粉酶的组合以及蛋白酶抑制剂。 本发明还涉及使用这种制剂来调节人类和动物中恶性肿瘤的作用。

公开(公告)号：US10932510B2

公开(公告)日：2021-03-02

申请号：US16166123

申请日：2018-10-21

申请人： Miroslav Rybak

发明人： Miroslav Rybak

IPC分类号： A42B1/00 ,  A42B1/006 ,  A41D13/11 ,  A42B1/206 ,  A42B1/205 ,  A41D15/04

摘要： A convertible headwear comprising a kerchief, a headband, and a visor, wherein the kerchief, the headband, and the visor are irremovable interconnected to form a hat that is convertible into a face mask, wherein the headband comprises one terminal end and one other terminal end, wherein each of the one terminal end and the one other terminal end comprises at least one fastening element, wherein the at least one fastening element of the first terminal end is configured to removably connect to the at least one fastening element of the one other terminal end, wherein the visor is irremovably connected to the kerchief, and wherein the headband is irremovably connected to the kerchief.

公开(公告)号：US20190116905A1

公开(公告)日：2019-04-25

申请号：US16166123

申请日：2018-10-21

申请人： Miroslav Rybak

发明人： Miroslav Rybak

IPC分类号： A42B1/00 ,  A42B1/20 ,  A41D13/11

摘要： A convertible headwear comprising a kerchief, a headband, and a visor, wherein the kerchief, the headband, and the visor are irremovable interconnected to form a hat that is convertible into a face mask, wherein the headband comprises one terminal end and one other terminal end, wherein each of the one terminal end and the one other terminal end comprises at least one fastening element, wherein the at least one fastening element of the first terminal end is configured to removably connect to the at least one fastening element of the one other terminal end, wherein the visor is irremovably connected to the kerchief, and wherein the headband is irremovably connected to the kerchief.

公开(公告)号：US11672286B2

公开(公告)日：2023-06-13

申请号：US16924484

申请日：2020-07-09

申请人： Miroslav Rybak

发明人： Miroslav Rybak

IPC分类号： A41D3/00 ,  A41D27/04 ,  A41D27/10 ,  A42B1/048 ,  A41B7/00

CPC分类号： A41D3/00 ,  A41B7/00 ,  A41D27/04 ,  A41D27/10 ,  A42B1/048 ,  A41D2200/20 ,  A41D2300/33 ,  A41D2400/44

摘要： The present application provides a garment that includes: a sleeve, a cuff, a retainer, and a sleeve lining attached at one end thereof at a proximal end of the sleeve, the sleeve lining extendible outward sufficient to cover at least a portion of a wearer's hand and retractable inward at a distal end of the sleeve; the retainer having a first end attached at the distal end of the sleeve to the sleeve and the sleeve lining, wherein the retainer is configured to limit at least the retractable inward movement of the sleeve lining; the cuff is located at the distal end of the sleeve lining and comprises a padding removably coupled to the cuff at a location proximate to the wearer's palm.

公开(公告)号：US20180184729A1

公开(公告)日：2018-07-05

申请号：US15843386

申请日：2017-12-15

申请人： Miroslav Rybak

发明人： Miroslav Rybak

IPC分类号： A41D3/00 ,  A41D27/04 ,  A41D27/10 ,  A42B1/04

摘要： The present application provides a garment that includes: a hood, the hood having an opening at a front of the hood, the opening extending between a bottom and top of the hood; at least a first passageway meandering in a concave shape on at least one side of the hood and extending from the bottom front of the hood, rearward over a wearer's shoulder, transitioning vertically toward the top of the hood, and continuing at the top of the hood forward back over the wearer's shoulder toward the front of the hood; and at least way drawstring disposed within the first passageway.

公开(公告)号：US20230329364A1

公开(公告)日：2023-10-19

申请号：US17955145

申请日：2022-09-28

申请人： Miroslav Rybak

发明人： Miroslav Rybak

IPC分类号： A41D3/00 ,  A41D27/04 ,  A41D27/10 ,  A42B1/048 ,  A41B7/00

CPC分类号： A41D3/00 ,  A41D27/04 ,  A41D27/10 ,  A42B1/048 ,  A41B7/00 ,  A41D2400/44 ,  A41D2200/20 ,  A41D2300/33

摘要： The present application provides a garment that includes: a sleeve, a cuff, a retainer, and a sleeve lining attached at one end thereof at a proximal end of the sleeve, the sleeve lining extendible outward sufficient to cover at least a portion of a wearer's hand and retractable inward at a distal end of the sleeve; the retainer having a first end attached at the distal end of the sleeve to the sleeve and the sleeve lining, wherein the retainer is configured to limit at least the retractable inward movement of the sleeve lining; the cuff is located at the distal end of the sleeve lining and comprises a padding removably coupled to the cuff at a location proximate to the wearer's palm.

公开(公告)号：US5118614A

公开(公告)日：1992-06-02

申请号：US297753

申请日：1989-01-17

申请人： Miroslav Rybak ,  Evzen Kasafirek ,  Jitka Houskova ,  Cyril Losticky ,  Stanislav Ulrych ,  Oldrich Sedlmaier ,  Alena Roubalova

发明人： Miroslav Rybak ,  Evzen Kasafirek ,  Jitka Houskova ,  Cyril Losticky ,  Stanislav Ulrych ,  Oldrich Sedlmaier ,  Alena Roubalova

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/43 ,  A61K49/00 ,  C07K14/435 ,  C07K14/745 ,  C12N9/64 ,  C12Q1/56 ,  G01N33/52

CPC分类号： C12N9/647 ,  C12Q1/56 ,  G01N33/523 ,  A61K38/00 ,  C12Q2337/12 ,  G01N2333/96444 ,  G01N2333/96447 ,  G01N2333/9645 ,  G01N2333/974

摘要： The claimed invention concerns concentrates of coagulation factors II, VII, IX and X and the method of their preparation by selective adsorption on an equilibrated carrier of hydroxyethylmethacrylate or hydroxyethylacrylate with bound diethylaminoethyl groups, followed by selective elution.The concentrates of coagulation factors II and X can be used to detect coagulation factor VII and in a laboratory method for the detection or determination of the extent of mammalian inflammatory diseases.

公开(公告)号：US4898930A

公开(公告)日：1990-02-06

申请号：US62300

申请日：1987-06-12

申请人： Evzen Kasafirek ,  Miroslav Rybak ,  Ivan Krejci ,  Antonin Sturc ,  Alena Roubalova ,  Jiri Vanzura ,  Evzen Krepela ,  Michal Bartik

发明人： Evzen Kasafirek ,  Miroslav Rybak ,  Ivan Krejci ,  Antonin Sturc ,  Alena Roubalova ,  Jiri Vanzura ,  Evzen Krepela ,  Michal Bartik

IPC分类号： C07K5/08 ,  A61K38/00 ,  C07D241/08 ,  C07K5/062 ,  C07K5/065 ,  C07K5/068 ,  C07K5/083 ,  C07K5/087 ,  C07K5/09 ,  C07K5/10 ,  C07K5/103 ,  C07K5/107 ,  C07K5/11 ,  C07K7/06 ,  C12P21/02

CPC分类号： C07K5/06086 ,  C07K5/0806 ,  C07K5/0808 ,  C07K5/0812 ,  A61K38/00

摘要： Peptide ester and amide derivatives of the general formula I: ##STR1## in which X is H or an acyl, A and B are structurally defined amino acid residues, n is an integer of from 1 to 3, R.sup.1 is H or a lower alkyl and either R.sup.2 or C is a defined optionally modified amino acid residue and the other is a lower alkoxyl, an amino group or a direct chemical bond, are converted under physiologic conditions, by enzymic hydrolysis in pathologically altered tissues and subsequent spontaneous cyclization, into pharmacodynamically active spirocyclic peptide derivatives of the general formula III: ##STR2## in which R.sup.3 and R.sup.4 are H atoms, optionally substituted alkyl groups or jointly an aliphatic chain forming preferably a 2,5- piperazinedione ring, and hence can act as pro-farmaca (drug precursors) of prolonged biological effect.

摘要翻译： 通式I的肽酯和酰胺衍生物：其中X为H或酰基，A和B为结构定义的氨基酸残基，n为1至3的整数，R 1为H或低级烷基 并且R2或C是限定的任选修饰的氨基酸残基，另一个是低级烷氧基，氨基或直接化学键，在生理条件下通过酶水解在病理改变的组织中并随后自发环化转化为药效学 通式III的活性螺环肽衍生物：其中R 3和R 4是H原子，任选取代的烷基或共同形成优选2,5-哌嗪二酮环的脂族链，因此可以作为亲农 药物前体）具有延长的生物学效应。