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    Diene compound and process for producing the same
    1.
    发明授权
    Diene compound and process for producing the same 失效
    二烯化合物及其制备方法

    公开(公告)号：US06323174B1

    公开(公告)日：2001-11-27

    申请号：US09571549

    申请日：2000-05-16

    申请人： Mitsuhiko Fujiwhara ,  Takenobu Nishikawa ,  Yoji Hori ,  Toshimitsu Hagiwara ,  Hisao Iwai ,  Takashi Miura

    发明人： Mitsuhiko Fujiwhara ,  Takenobu Nishikawa ,  Yoji Hori ,  Toshimitsu Hagiwara ,  Hisao Iwai ,  Takashi Miura

    IPC分类号： A61K746

    CPC分类号： C11B9/0019 ,  C07C2/04 ,  C07C45/54 ,  C07C47/21 ,  C07C67/293 ,  C07C2531/22 ,  C11B9/0007 ,  C07C11/12 ,  C07C69/007 ,  C07C69/145 ,  C07C69/16 ,  C07C69/24

    摘要： The invention provides a chain diene compound with desirable regioselectivity, in the presence of a specific ruthenium compound. This chain diene compound is a promising raw material for terpene. It has a structure represented by the general formula (I): wherein R1 represents H, a C1-C6 alkyl group which may be substituted or a C2-C6 alkenyl group which may be substituted, R2 represents a phenyl group which may have a C1-C4 alkyl group or a C1-C12 acyloxy group which may have a phenyl group or a naphthyl group, or a benzyl group or R2 is a hydroxy group which reversibly forms an aldehyde group through shifting of the position of the double bond adjacent to said hydroxy group. The chain diene compound is produced by reacting 2-substituted-1,3-butadienes with terminal olefins in the presence of a ruthenium compound in a hydrophilic solvent. Further, the above method provides an inexpensive process for preparing a mild fragrant component and a perfume composition, such as 4-methyl-5-hexen-1-al and 4-vinyl-8-methyl-7-nonenal.

    摘要翻译： 在特定的钌化合物的存在下，本发明提供具有理想的区域选择性的链二烯化合物。 该链二烯化合物是萜烯的有希望的原料。 它具有由通式（I）表示的结构：其中R1表示H，可被取代的C1-C6烷基或可被取代的C2-C6烯基，R2表示可具有C1 -C4烷基或可以具有苯基或萘基的C1-C12酰氧基或苄基，或R2是通过使所述双键邻近的所述双键移位而可逆地形成醛基的羟基 羟基。 链二烯化合物通过在亲水性溶剂中在钌化合物的存在下使2-取代-1,3-丁二烯与末端烯烃反应制备。 此外，上述方法提供了用于制备温和香料组分和香料组合物的廉价方法，例如4-甲基-5-己烯-1-醇和4-乙烯基-8-甲基-7-壬烯醛。

    Diene compound and process for producing the same
    2.
    发明授权
    Diene compound and process for producing the same 失效
    二烯化合物及其制备方法

    公开(公告)号：US06239324B1

    公开(公告)日：2001-05-29

    申请号：US09383920

    申请日：1999-08-26

    申请人： Mitsuhiko Fujiwhara ,  Takenobu Nishikawa ,  Yoji Hori ,  Toshimitsu Hagiwara ,  Hisao Iwai ,  Takashi Miura

    发明人： Mitsuhiko Fujiwhara ,  Takenobu Nishikawa ,  Yoji Hori ,  Toshimitsu Hagiwara ,  Hisao Iwai ,  Takashi Miura

    IPC分类号： C07C202

    CPC分类号： C11B9/0019 ,  C07C2/04 ,  C07C45/54 ,  C07C47/21 ,  C07C67/293 ,  C07C2531/22 ,  C11B9/0007 ,  C07C11/12 ,  C07C69/007 ,  C07C69/145 ,  C07C69/16 ,  C07C69/24

    摘要： The invention provides a chain diene compound with desirable regioselectivity, in the presence of a specific ruthenium compound. This chain diene compound is a promising raw material for terpene. It has a structure represented by the general formula (IX): wherein R1 represents H, a C1-C6 alkyl group which may be substituted or a C2-C6 alkenyl group which may be substituted, R2 represents a phenyl group which may have a C1-C4 alkyl group or a C1-C12 acyloxy group which may have a phenyl group or a naphthyl group, or a benzyl group or R2 is a hydroxy group which reversibly forms an aldehyde group through shifting of the position of the double bond adjacent to said hydroxy group. The chain diene compound is produced by reacting 2-substituted-1,3-butadienes with terminal olefins in the presence of a ruthenium compound in a hydrophilic solvent. Further, the above method provides an inexpensive process for preparing a mild fragrant component and a perfume composition, such as 4-methyl-5-hexen-1-al and 4-vinyl-8-methyl-7-nonenal.

    摘要翻译： 在特定的钌化合物的存在下，本发明提供具有理想的区域选择性的链二烯化合物。 该链二烯化合物是萜烯的有希望的原料。 其具有由通式（IX）表示的结构：其中R 1表示H，可被取代的C 1 -C 6烷基或可被取代的C 2 -C 6烯基，R 2表示可具有C 1 -C4烷基或可以具有苯基或萘基的C1-C12酰氧基或苄基，或R2是通过使所述双键邻近的所述双键的位置的移动可逆地形成醛基的羟基 羟基。 链二烯化合物通过在亲水性溶剂中在钌化合物的存在下使2-取代-1,3-丁二烯与末端烯烃反应制备。 此外，上述方法提供了用于制备温和香料组分和香料组合物的廉价方法，例如4-甲基-5-己烯-1-醇和4-乙烯基-8-甲基-7-壬烯醛。

    Method for preparing optically active beta-butyrolactones
    5.
    发明申请
    Method for preparing optically active beta-butyrolactones 审中-公开
    制备光学活性β-丁内酯的方法

    公开(公告)号：US20060046286A1

    公开(公告)日：2006-03-02

    申请号：US11209643

    申请日：2005-08-24

    申请人： Shinya Watanabe ,  Mitsuhiko Fujiwhara ,  Noboru Sayo

    发明人： Shinya Watanabe ,  Mitsuhiko Fujiwhara ,  Noboru Sayo

    IPC分类号： C12P17/04 ,  C12P41/00

    CPC分类号： C12P17/04 ,  C12P41/001

    摘要： The present invention is to provide a method for preparing easily and efficiently β-butyrolactones and/or optically active 3-hydroxycarboxylic acid derivatives in high optical purity by use of an easily available hydrolase, which are useful as intermediates for pharmaceuticals, agrochemicals and the like. More particularly, the present invention relates to a method for preparing β-butyrolactones and/or optically active 3-hydroxycarboxylic acid derivatives with an optical purity of substantially 100% ee, comprising reacting a β-butyrolactone which is a mixture of optical isomers, with a nucleophilic agent in the presence of a hydrolase, provided that a lipase derived from porcine pancreas is excluded.

    摘要翻译： 本发明是提供一种通过使用易于获得的水解酶来制备高光学纯度的β-丁内酯和/或光学活性3-羟基羧酸衍生物的方法，其可用作药物，农业化学品等的中间体 。 更具体地，本发明涉及一种制备光学纯度基本上为100％ee的β-丁内酯和/或光学活性3-羟基羧酸衍生物的方法，包括使作为旋光异构体的混合物的β-丁内酯与 亲水试剂在水解酶存在下，条件是排除源自猪胰腺的脂肪酶。