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公开(公告)号：US20150044763A1
公开(公告)日：2015-02-12
申请号：US14381904
申请日：2013-03-22
申请人： Mitsui Engineering & Shipbuilding Co., Ltd. , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人： Shigeyuki Nakada , Yusuke Ohba , Kyouji Doi , Yumi Asano
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , G01N15/1429 , G01N21/6408 , G01N33/542 , G01N2201/06113 , G16B20/00
摘要： FRET measurement uses a FRET probe that includes a probe element X labeled with a donor fluorescent substance and a probe element Y labeled with an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. A test sample as a measuring object in FRET measurement contains a test object about which it is unknown whether or not it has an approaching/binding property of allowing the probe element X and the probe element Y to approach to each other or bind together or a separating property of separating from each other the probe element X and the probe element Y that are in a state where they adjoin each other or bind together. A plurality of sets of a fluorescence lifetime τsample and a ratiometry Rsample obtained by this measurement are used to judge whether or not the test object has the approaching/binding property or the separating property.
摘要翻译： FRET测量使用FRET探针，其包括用供体荧光物质标记的探针元件X和用受体荧光物质标记的探针元件Y，并且当探针元件X和探针元件Y彼此接近或结合时能够发生FRET 一起。 在FRET测量中作为测量对象的测试样本包含测试对象，关于它是否具有允许探针元件X和探针元件Y彼此接近或结合在一起的接近/结合属性，或者 分离彼此分离的探针元件X和探针元件Y彼此相邻或结合在一起的状态。 使用通过该测量获得的多组荧光寿命τsample和比率测定Rsample来判断测试对象是否具有接近/结合性或分离性。
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公开(公告)号：US09291563B2
公开(公告)日：2016-03-22
申请号：US14381915
申请日：2013-03-22
申请人： Mitsui Engineering & Shipbuilding Co., Ltd. , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人： Shigeyuki Nakada , Yusuke Ohba , Kyouji Doi , Yumi Asano
IPC分类号： G01N21/64 , G01N33/542 , C12Q1/68
CPC分类号： G01N21/6428 , C12Q1/6818 , G01N21/6408 , G01N21/6458 , G01N33/542 , G01N2021/6441 , C12Q2523/313
摘要： FRET measurement uses a FRET probe that includes a probe element X containing a donor fluorescent substance and a probe element Y containing an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. The modulation frequency of laser light with which the FRET probe is irradiated is adjusted to an optimum modulation frequency that maximizes a difference between the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET occurs and the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET does not occur.
摘要翻译： FRET测量使用FRET探针，其包括含有供体荧光物质的探针元件X和含有受体荧光物质的探针元件Y，并且当探针元件X和探针元件Y彼此接近或结合在一起时，FRET能够发生FRET。 将FRET探针照射的激光的调制频率调整到最佳调制频率，使调制器荧光物质发射的供体荧光相位差与激光强度调制之间的差最大化， FRET发生时，与供体荧光物质发射的供体荧光相对于FRET不发生时的激光强度调制的相位差。
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公开(公告)号：US20150044690A1
公开(公告)日：2015-02-12
申请号：US14381915
申请日：2013-03-22
申请人： Mitsui Engineering & Shipbuilding Co., Ltd. , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
发明人： Shigeyuki Nakada , Yusuke Ohba , Kyouji Doi , Yumi Asano
IPC分类号： G01N21/64 , G01N33/542
CPC分类号： G01N21/6428 , C12Q1/6818 , G01N21/6408 , G01N21/6458 , G01N33/542 , G01N2021/6441 , C12Q2523/313
摘要： FRET measurement uses a FRET probe that includes a probe element X containing a donor fluorescent substance and a probe element Y containing an acceptor fluorescent substance and enables FRET to occur when the probe element X and the probe element Y approach to each other or bind together. The modulation frequency of laser light with which the FRET probe is irradiated is adjusted to an optimum modulation frequency that maximizes a difference between the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET occurs and the phase difference of donor fluorescence emitted from the donor fluorescent substance with respect to intensity modulation of the laser light at the time when FRET does not occur.
摘要翻译： FRET测量使用FRET探针，其包括含有供体荧光物质的探针元件X和含有受体荧光物质的探针元件Y，并且当探针元件X和探针元件Y彼此接近或结合在一起时，FRET能够发生FRET。 将FRET探针照射的激光的调制频率调整到最佳调制频率，使调制器荧光物质发射的供体荧光相位差与激光强度调制之间的差最大化， FRET发生时，与供体荧光物质发射的供体荧光相对于FRET不发生时的激光强度调制的相位差。
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公开(公告)号：US09746555B2
公开(公告)日：2017-08-29
申请号：US14534978
申请日：2014-11-06
发明人： Yasunari Mori , Kyouji Doi , Takayoshi Yumii , Yumi Asano
摘要： The planar antenna has a dielectric substrate; an antenna main body portion including first and second antenna elements on first and second sides, respectively, of the dielectric substrate and functioning as a balanced antenna; a signal line portion including first and second feed lines on the first and second sides, respectively, and a coplanar line on the first side and formed by a signal line and the first ground conductors, the signal line connected to the first feed line; a second ground conductor on the second side and connected to the second feed line; and via holes connecting the first ground conductors to the second ground conductor provided at ends of edges of the first ground conductors facing the end of the signal line where the signal line connects to the first feed line, to allow the first and second feed lines to function as balanced transmission lines.
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