公开(公告)号：US20090258094A1

公开(公告)日：2009-10-15

申请号：US12422146

申请日：2009-04-10

申请人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

发明人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

IPC分类号： A61K31/12 ,  A61K31/56 ,  A61K36/886 ,  A61K36/00 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08 ,  A61P17/10 ,  A61P17/16 ,  A61P17/18

CPC分类号： A61K36/185

摘要： A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.

摘要翻译： 一种制备富含黄腐酚的啤酒花组合物的方法。 该方法包括提供含有含黄腐酚的啤酒花物质的溶液，并通过调节溶液的盐浓度和pH值来实现非黄褐酮啤酒花物质的沉淀。 通过该方法制备的富含黄腐酚酸的啤酒花组合物可用于治疗各种疾病，例如皮肤病和细菌感染。

公开(公告)号：US08142821B2

公开(公告)日：2012-03-27

申请号：US12422146

申请日：2009-04-10

申请人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

发明人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

IPC分类号： A01N65/00

CPC分类号： A61K36/185

摘要： A method for preparing a xanthohumol-rich hop composition. The method includes providing a solution that contains xanthohumol-containing hop substances and effecting precipitation of non-xanthohumol hop substances by adjusting both the salt concentration and pH value of the solution. The xanthohumol-rich hop composition prepared by this method can be used for treating various diseases, e.g., skin disorders, and bacterial infection.

摘要翻译： 一种制备富含黄腐酚的啤酒花组合物的方法。 该方法包括提供含有含黄腐酚的啤酒花物质的溶液，并通过调节溶液的盐浓度和pH值来实现非黄褐酮啤酒花物质的沉淀。 通过该方法制备的富含黄腐酚酸的啤酒花组合物可用于治疗各种疾病，例如皮肤病和细菌感染。

公开(公告)号：US20110207697A1

公开(公告)日：2011-08-25

申请号：US12937237

申请日：2009-04-10

申请人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

发明人： Mitsunori Ono ,  Naoto Yamaguchi ,  Keiko Yamaguchi

IPC分类号： A61K31/724 ,  A61K8/73 ,  A61K31/122 ,  A61K8/35 ,  A61P17/00 ,  A61P31/04 ,  A61Q19/08

CPC分类号： A61Q19/00 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/35 ,  A61K8/738 ,  A61K2800/92 ,  A61Q19/02 ,  A61Q19/08 ,  C08B37/0015 ,  C08L5/16 ,  A23V2200/318 ,  A23V2250/21 ,  A23V2250/5112

摘要： The present invention features therapeutic and prophylactic compositions comprising xanthohumol and/or xanthohumol/cyclodextrin complexes and methods of using such compositions for treating a skin condition, disease, or disorder.

摘要翻译： 本发明的特征在于包含黄腐酚和/或黄曲霉酚/环糊精复合物的治疗和预防组合物以及使用这些组合物治疗皮肤病症，疾病或病症的方法。

公开(公告)号：US20070280982A1

公开(公告)日：2007-12-06

申请号：US11731764

申请日：2007-03-29

申请人： Mitsunori Ono ,  Keiko Yamaguchi ,  Naoto Yamaguchi

发明人： Mitsunori Ono ,  Keiko Yamaguchi ,  Naoto Yamaguchi

IPC分类号： A23L3/34 ,  A01N25/08

CPC分类号： A23L3/3472 ,  A01N61/00 ,  A01N65/08 ,  A23L3/3463

摘要： The invention features anti-microbial compositions comprising compositions of hop acid alkali metal salts and alkaline earth metal salts and methods of using them to inhibit microbial growth.

摘要翻译： 本发明的特征在于包含Hop酸碱金属盐和碱土金属盐组合物的抗微生物组合物和使用它们抑制微生物生长的方法。

公开(公告)号：US08966618B2

公开(公告)日：2015-02-24

申请号：US12313639

申请日：2008-11-21

申请人： Keiko Yamaguchi ,  Takashi Araki

发明人： Keiko Yamaguchi ,  Takashi Araki

IPC分类号： G06F21/62 ,  G06F21/10

CPC分类号： G06F21/10 ,  G06F21/105

摘要： Provided is a license management system comprising: a license check device that independently operates on a platform; and an information processing device that is connected to the license check device, in which the license check device includes: a license check unit that checks for presence or absence of a license of the information processing device; a first start unit that starts the license check unit in response to a call instructed by the platform; and a calling unit that calls, when the license check unit determines that the license is present, the information processing device, and in which the information processing device includes: an information processing unit that performs a specific information processing; and a second start unit that starts the information processing unit only in response to the call from the license check device.

公开(公告)号：US20110294986A1

公开(公告)日：2011-12-01

申请号：US13207837

申请日：2011-08-11

申请人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

发明人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

IPC分类号： C07K16/28

CPC分类号： C07K16/18 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/569 ,  C07K2317/76 ,  G01N33/56972 ,  G01N2333/075 ,  G01N2333/085

摘要： The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies. These are expected to be useful in diagnosing diseases, such as inflammation, in which infiltration of Th1 cells is involved, and in providing pharmaceutical agents for alleviating such diseases.

摘要翻译： 本发明人发现已知局限在细胞内粘附位点的粘附分子CAR用作活化淋巴细胞的粘附分子。 此外，本发明人鉴定了CARL，一种在淋巴细胞中表达的新型CAR配体，并阐明了配体在Th1细胞中有选择性表达。 此外，他们发现抗CAR抗体可以抑制活化淋巴细胞对CAR分子的粘附。 因此，本发明提供了使用CAR或抗CARL抗体检测Th1细胞的方法，以及使用CAR和CARL之间的结合作为指标筛选抑制Th1细胞粘附的抑制剂的方法。 此外，本发明涉及筛选CAR和CARL之间的结合抑制剂的方法，抑制CAR和CARL之间的结合的抗体以及包含这些抗体的治疗组合物。 预期这些可用于诊断涉及Th1细胞浸润的疾病，例如炎症，以及提供减轻这些疾病的药物。

公开(公告)号：US08017344B2

公开(公告)日：2011-09-13

申请号：US11568435

申请日：2005-04-28

申请人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

发明人： Keiko Yamaguchi ,  Toshio Imai ,  Kenzo Muramoto

IPC分类号： G01N33/53

CPC分类号： C07K16/18 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/569 ,  C07K2317/76 ,  G01N33/56972 ,  G01N2333/075 ,  G01N2333/085

摘要： The inventors discovered that the adhesion molecule CAR, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified CARL, a novel CAR ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in Th1 cells. In addition, they found that anti-CAR antibodies could inhibit the adhesion of activated lymphocytes to CAR molecules. Thus, the present invention provides methods for detecting Th1 cells using CAR or anti-CARL antibodies, and methods of screening for inhibitors suppressing the adhesion of Th1 cells using the binding between CAR and CARL as an index. Furthermore, the present invention relates to methods of screening for inhibitors of the binding between CAR and CARL, antibodies that inhibit the binding between CAR and CARL, and therapeutic compositions comprising these antibodies. These are expected to be useful in diagnosing diseases, such as inflammation, in which infiltration of Th1 cells is involved, and in providing pharmaceutical agents for alleviating such diseases.

摘要翻译： 本发明人发现已知局限在细胞内粘附位点的粘附分子CAR用作活化淋巴细胞的粘附分子。 此外，本发明人鉴定了CARL，一种在淋巴细胞中表达的新型CAR配体，并阐明了配体在Th1细胞中有选择性表达。 此外，他们发现抗CAR抗体可以抑制活化淋巴细胞对CAR分子的粘附。 因此，本发明提供了使用CAR或抗CARL抗体检测Th1细胞的方法，以及使用CAR和CARL之间的结合作为指标筛选抑制Th1细胞粘附的抑制剂的方法。 此外，本发明涉及筛选CAR和CARL之间的结合抑制剂的方法，抑制CAR和CARL之间的结合的抗体以及包含这些抗体的治疗组合物。 预期这些可用于诊断涉及Th1细胞浸润的疾病，例如炎症，以及提供减轻这些疾病的药物。

公开(公告)号：US20090154370A1

公开(公告)日：2009-06-18

申请号：US12298173

申请日：2007-04-27

申请人： Keiko Yamaguchi

发明人： Keiko Yamaguchi

IPC分类号： H04L12/26 ,  H04B7/216

CPC分类号： H04B1/7097 ,  H04B17/336 ,  H04B17/373 ,  H04B2201/70701

摘要： When a processing delay detection unit (27) detects that an end timing (F) of measurement of the reception quality of a common pilot signal transmitted from a wireless base station has delayed from a creation start time limit for reception quality information, approximate reception quality information (k) is created on the basis of reception quality measured before the creation start time limit. The approximate reception quality information is transmitted to a wireless base station. The delay of the transmission timing of the reception quality information can be prevented, and the wireless base station can quickly set the transmission rate of transmission data to a cellular phone.

摘要翻译： 当处理延迟检测单元（27）检测到从无线基站发送的公共导频信号的接收质量的测量的结束定时（F）已经从接收质量信息的创建开始时间限制延迟时，近似接收质量 基于在创建开始时间限制之前测量的接收质量创建信息（k）。 近似接收质量信息被发送到无线基站。 可以防止接收质量信息的发送定时的延迟，并且无线基站能够快速地将传输数据的传输速率设置到蜂窝电话。

公开(公告)号：US6072205A

公开(公告)日：2000-06-06

申请号：US090533

申请日：1998-06-04

申请人： Keiko Yamaguchi ,  Naotaka Iwata

发明人： Keiko Yamaguchi ,  Naotaka Iwata

IPC分类号： H01L27/04 ,  H01L21/822 ,  H01L27/01 ,  H01L29/80 ,  H01L31/112

CPC分类号： H01L27/01 ,  H01L2224/45144 ,  H01L2224/48091 ,  H01L2924/30107 ,  H01L2924/3011

摘要： A passive element circuit is formed by a spiral inductor, a high-dielectric-constant thin-film capacitor, a via hole, and a bonding pad. By using SrTiO.sub.3 as the high-dielectric-constant thin-film, which exhibits a dielectric constant of 200 up to a frequency of 20 GHz, it is possible to achieve a reduction of the capacitor surface area to approximately 1/30 of the area formerly required when using a SiN.sub.x (dielectric constant up to 6.5). Two high-dielectric-constant thin-film capacitors, a via hole for grounding, and a bonding pad are disposed at the center, which are surrounded by the spiral inductor. To connect the two high-dielectric-constant thin-film capacitors are joined in series, they are formed on one high-dielectric-constant thin-film. A lead from the spiral inductor is made by a metal wire from the bonding pad at the center.

摘要翻译： 无源元件电路由螺旋电感器，高介电常数薄膜电容器，通孔和接合焊盘构成。 通过使用SrTiO3作为介电常数为200的高介电常数薄膜，直到20GHz的频率，可以使电容器表面积减小到大约+ E，从而使1/30 +使用SiNx（介电常数高达6.5）以前要求的区域。 两个高介电常数薄膜电容器，一个用于接地的通孔和一个接合焊盘设置在中心，被螺旋电感器包围。 为了连接两个高介电常数薄膜电容器串联连接，它们形成在一个高介电常数的薄膜上。 来自螺旋电感器的引线由来自中心的焊盘的金属线制成。

公开(公告)号：US07983184B2

公开(公告)日：2011-07-19

申请号：US12298173

申请日：2007-04-27

申请人： Keiko Yamaguchi

发明人： Keiko Yamaguchi

IPC分类号： H04J3/14

CPC分类号： H04B1/7097 ,  H04B17/336 ,  H04B17/373 ,  H04B2201/70701

摘要： When a processing delay detection unit (27) detects that an end timing (F) of measurement of the reception quality of a common pilot signal transmitted from a wireless base station has delayed from a creation start time limit for reception quality information, approximate reception quality information (k) is created on the basis of reception quality measured before the creation start time limit. The approximate reception quality information is transmitted to a wireless base station. The delay of the transmission timing of the reception quality information can be prevented, and the wireless base station can quickly set the transmission rate of transmission data to a cellular phone.

摘要翻译： 当处理延迟检测单元（27）检测到从无线基站发送的公共导频信号的接收质量的测量的结束定时（F）已经从接收质量信息的创建开始时间限制延迟时，近似接收质量 基于在创建开始时间限制之前测量的接收质量创建信息（k）。 近似接收质量信息被发送到无线基站。 可以防止接收质量信息的发送定时的延迟，并且无线基站能够快速地将传输数据的传输速率设置到蜂窝电话。