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公开(公告)号：US06399035B1
公开(公告)日：2002-06-04
申请号：US09401931
申请日：1999-09-22
IPC分类号： B01D5394
CPC分类号： B01D53/9418 , B01D2251/208 , B01D2251/21 , B01D2255/1023 , B01D2255/1025 , B01D2255/1026 , B01D2255/1028 , B01D2255/20707 , B01D2258/012 , B01J23/14 , B01J23/626
摘要： A reduction purification method of a nitrogen oxide-containing exhaust gas by contacting said nitrogen oxide-containing exhaust gas with a catalyst in an oxidative atmosphere in which an excess amount of oxygen is present and in the presence of a least one reducing agent selected from the group consisting of a hydrocarbon and an oxygen-containing organic compound, wherein said catalyst comprises an alumina having supported thereon (a) tin and (b) at least one selected from the group consisting of ruthenium, palladium, rhodium and indium.
摘要翻译： 一种含氮氧化物废气的还原净化方法，其特征在于，在存在过量氧的氧化性气氛中，在所述含氮氧化物的废气与催化剂的存在下，在选自 由烃和含氧有机化合物组成的组，其中所述催化剂包括其上负载有（a）锡的氧化铝和（b）选自钌，钯，铑和铟中的至少一种。
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公开(公告)号：US6030590A
公开(公告)日：2000-02-29
申请号：US773363
申请日：1996-12-26
CPC分类号： B01D53/9418 , B01J23/14 , B01J23/626 , B01D2251/208 , B01D2251/21 , B01D2255/1023 , B01D2255/1025 , B01D2255/1026 , B01D2255/1028 , B01D2255/20707 , B01D2258/012
摘要： A reduction purification method of a nitrogen oxide-containing exhaust gas by contacting said nitrogen oxide-containing exhaust gas with a catalyst in an oxidative atmosphere in which an excess amount of oxygen is present and in the presence of at least one reducing agent selected from the group consisting of a hydrocarbon and an oxygen-containing organic compound, wherein said catalyst comprises an alumina having supported thereon (a) tin and (b) at least one selected from the group consisting of ruthenium, palladium, rhodium and indium.
摘要翻译： 一种含氮氧化物废气的还原净化方法，其特征在于，在存在过量氧的氧化性气氛中，在所述含氮氧化物的废气与催化剂的存在下，在至少一种还原剂的存在下， 由烃和含氧有机化合物组成的组，其中所述催化剂包括其上负载有（a）锡的氧化铝和（b）选自钌，钯，铑和铟中的至少一种。
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公开(公告)号：US5853679A
公开(公告)日：1998-12-29
申请号：US733697
申请日：1996-10-17
申请人： Mitsunori Tabata , Masaaki Kawatsuki , Katsumi Miyamoto , Hiroshi Tsuchida , Tomohiro Yoshinari , Kazushi Usui , Fujio Suganuma , Tadao Nakatsuji , Hiromitsu Shimizu , Ritsu Yasukawa , Hideaki Hamada , Takehiko Ito , Yoshiaki Kintaichi , Motoi Sasaki
发明人： Mitsunori Tabata , Masaaki Kawatsuki , Katsumi Miyamoto , Hiroshi Tsuchida , Tomohiro Yoshinari , Kazushi Usui , Fujio Suganuma , Tadao Nakatsuji , Hiromitsu Shimizu , Ritsu Yasukawa , Hideaki Hamada , Takehiko Ito , Yoshiaki Kintaichi , Motoi Sasaki
CPC分类号： B01D53/8628 , B01D53/9418 , B01J23/02 , B01J35/10 , B01D2251/208 , B01D2251/21 , B01D2255/202 , B01D2255/204 , B01D2258/012 , B01J35/1038 , B01J35/1042 , B01J35/1061 , B01J35/1085 , F02B2075/027 , F02B3/06
摘要： A process for removing nitrogen oxide from exhaust is disclosed, comprising contacting exhaust containing nitrogen oxide with an alumina catalyst which contains not more than 0.5% by weight of an alkali metal and/or an alkaline earth metal and has a total pore volume of from 0.48 to 1.2 cm.sup.3 .multidot.g.sup.-1 with 0.26 to 0.6 cm.sup.3 .multidot.g.sup.-1 of the total pore volume being formed of pores of not greater than 80 .ANG. or has a volume of pores formed of pores of not greater than 60 .ANG. of from 0.06 to 0.2 cm.sup.3 .multidot.g.sup.-l and which may have supported thereon tin in an oxidative atmosphere containing excess oxygen in the presence of a hydrocarbon or an oxygen-containing organic compound.
摘要翻译： 公开了一种从排气中除去氮氧化物的方法，包括使含氮氧化物的废气与氧化铝催化剂接触，氧化铝催化剂含有不超过0.5重量％的碱金属和/或碱土金属，总孔体积为0.48 至1.2cm 3×g -1，其总孔体积的0.26至0.6cm 3×g -1由不大于80的孔形成，或具有由不大于60的孔形成的孔的体积为0.06至0.2cm 3×g -1 并且其可以在烃或含氧有机化合物的存在下，在含有过量氧的氧化气氛中负载锡。
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公开(公告)号：US20110045028A1
公开(公告)日：2011-02-24
申请号：US12516536
申请日：2007-11-29
IPC分类号： A61K31/513 , A61K9/00 , A61P7/02 , A61P9/10
CPC分类号： A61K31/506 , A61K9/2018 , A61K9/2054
摘要： Disclosed is a sustained-release preparation which is prepared by shaping a granule comprising a blood coagulation factor Xa inhibitor and a mixture of at least two hydrophilic polymers. Also disclosed is a pharmaceutical composition comprising a combination of the sustained-release preparation and an immediate release preparation comprising a blood coagulation factor Xa inhibitor. It becomes possible to provide a controlled release preparation comprising a blood coagulation factor Xa inhibitor for the prevention or treatment of thrombosis, which can control the activity of blood coagulation factor Xa for a long term and is excellent in convenience and compliance. It is also becomes possible to provide a method for producing the controlled release preparation.
摘要翻译： 公开了一种缓释制剂，其通过使包含凝血因子Xa抑制剂和至少两种亲水性聚合物的混合物的颗粒成形而制备。 还公开了包含缓释制剂和包含凝血因子Xa抑制剂的速释制剂的组合的药物组合物。 可以提供一种控制释放制剂，其包含凝血因子Xa抑制剂，用于预防或治疗血栓形成，其可以长期控制凝血因子Xa的活性，并且方便性和顺应性优异。 也可以提供一种制备控释制剂的方法。
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公开(公告)号：US20090208584A1
公开(公告)日：2009-08-20
申请号：US11921664
申请日：2006-06-09
IPC分类号： A61K9/14 , A61K47/38 , A61K31/538
CPC分类号： A61K9/2095 , A61K9/1623 , A61K9/1652 , A61K9/2009 , A61K9/2018 , A61K9/2054 , A61K9/2077 , A61K9/2866 , A61K31/536
摘要： The solid preparation of the present invention aims at providing a solid preparation superior in the stability during production and preservation even when a poorly water-soluble substance having a low melting point is contained in a large amount, and also superior in the disintegration property and release property of a poorly water-soluble substance having a low melting point, after oral administration, and is characterized by the following 1) to 3): 1) containing a poorly water-soluble substance having a low melting point, a saccharide, and a cellulose selected from a crystalline cellulose and a low-substituted hydroxypropylcellulose, 2) a saccharide/cellulose weight ratio exceeding 2, and 3) a cellulose content of not less than 5 wt %.
摘要翻译： 本发明的固体制剂的目的在于提供即使在大量含有低熔点的难溶性水溶性物质的情况下，在制造和保存中的稳定性方面也优异的固体制剂，并且还具有优异的崩解性和脱模性 口服后具有低熔点的水溶性差的物质的性质，其特征在于以下1）〜3）：1）含有低熔点的水难溶性物质，糖类和 选自结晶纤维素和低取代羟丙基纤维素的纤维素，2）糖/纤维素重量比超过2，和3）纤维素含量不小于5重量％。
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公开(公告)号：US06235947B1
公开(公告)日：2001-05-22
申请号：US09155978
申请日：1998-10-23
IPC分类号： C07C3118
摘要： D-mannitol having a specific surface area of not less than about 1 m2/g is disclosed. The D-mannitol shows improved compressibility and is useful as an excipient.
摘要翻译： 公开了比表面积不小于约1m 2 / g的D-甘露糖醇。 D-甘露醇显示出改进的可压缩性并且可用作赋形剂。
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公开(公告)号：US08927011B2
公开(公告)日：2015-01-06
申请号：US12601158
申请日：2008-05-20
申请人： Hiroshi Suzuki , Tomohiro Yoshinari
发明人： Hiroshi Suzuki , Tomohiro Yoshinari
IPC分类号： A61K9/20 , A61K31/44 , A61K31/485 , A61K47/12
CPC分类号： A61K9/2013 , A61K9/2077 , A61K31/485 , A61K47/12
摘要： A process for advantageously producing tablets having an improved release property and an excellent stability to change with time is provided. The process is for producing tablets containing a morphinan compound represented by the Formula (I) below or pharmaceutically acceptable acid addition salt thereof and an acidic substance such as fumaric acid, maleic acid or adipic acid, and characterized in that the morphinan compound or a pharmaceutically acceptable acid addition salt thereof is granulated by wet granulation together with (an) excipient(s) prior to adding the acidic substance thereto.
摘要翻译： 提供了一种有利地制备具有改善的释放性能和优异的随时间变化的稳定性的片剂的方法。 该方法用于制备含有由下式（I）表示的吗啡喃化合物或其药学上可接受的酸加成盐和酸性物质如富马酸，马来酸或己二酸的片剂，其特征在于吗啡喃化合物或药学上可接受的盐 在将酸性物质加入其中之前，其可接受的酸加成盐与（a）赋形剂一起通过湿法制粒造粒。
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公开(公告)号：US20080031942A1
公开(公告)日：2008-02-07
申请号：US11667517
申请日：2005-12-02
CPC分类号： A61K9/2013 , A61K31/4178
摘要： A medical drug, in particular, solid preparations containing a medicinal ingredient with high tendency toward gelation, characterized by simultaneously containing a surface modifier and an acid or base. This characteristic realizes improvement to the disintegration easiness, production efficiency and stability of the solid preparations containing the above medicinal ingredient.
摘要翻译： 医药，特别是包含具有高凝胶化倾向的药用成分的固体制剂，其特征在于同时含有表面改性剂和酸或碱。 该特征实现了包含上述药物成分的固体制剂的崩解容易度，生产效率和稳定性的改善。
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9.发明授权
公开(公告)号：US5187133A
公开(公告)日：1993-02-16
申请号：US670719
申请日：1991-03-18
申请人： Tomohiro Yoshinari , Kazushi Usui , Yasuo Yamamoto , Mitsuru Ohi
发明人： Tomohiro Yoshinari , Kazushi Usui , Yasuo Yamamoto , Mitsuru Ohi
IPC分类号： B01J23/88 , B01J29/076 , B01J29/16 , B01J29/26 , B01J29/48 , B01J29/58 , B01J29/64 , B01J29/69 , B01J35/10 , C10G45/08 , C10G45/12
CPC分类号： C10G45/12
摘要： A catalyst composition for the hydrotreatment of hydrocarbon oils is disclosed. The composition comprises at least one metal compound having hydrogenating activity belonging to a Group VIB or Group VIII carried on a carrier comprising 2-35% by weight of zeolite and 98-65% by weight of alumina or an alumina-containing substance, wherein, (A) said alumina or alumina-containing substance (1) has a mean pore diameter of 60-125 angstrom and (2) contains the pore volume of which the diameter falls within .+-.10 angstrom of the mean pore diameter of 70-98% of the total pore volume, (B) said zeolite (3) has a mean particle size of 6 .mu.m or smaller and (4) contains particles of which the diameter is 6 .mu.m or smaller of 70-98% of all zeolite particles. It has both high hydrodesulfurization and high cracking capabilities at the same time, and can selectively crack the heavy fractions which have once been hydrotreated, yielding lighter fractions.
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10.发明授权Catalyst composition for hydrogenation of heavy hydrocarbon oil and process for producing the catalyst 失效用于重质烃油氢化的催化剂组合物和用于生产催化剂的方法
公开(公告)号：US4981832A
公开(公告)日：1991-01-01
申请号：US374805
申请日：1989-07-03
CPC分类号： B01J35/10 , B01J23/883 , C10G45/04 , B01J35/1042 , B01J35/1061 , B01J35/108
摘要： A catalyst composition for the hydrogenation of heavy hydrocarbon oil, where the catalyst composition comprises at least one active ingredient for hydrogenation supported on a porous alumina carrier and has the following characteristics: (1) the total volume of the pores therein is from 0.4 to 1.0 ml/g; (2) the mean pore diameter of pores having a pore diameter of from 5 to 400 .ANG. is from 60 to 140 .ANG.; (3) the volume of pores having a pore size within .+-.25% of the mean pore diameter of pores having a pore diameter of from 5 to 400 .ANG. is from 60 to 98% of the volume of pores having a pore diameter of from 5 to 400 .ANG.; (4) the volume of pores having a pore diameter of from 400 to 5000 .ANG. is from 2 to 9% of the total volume of the entire pores; (5) the ratio (mm.sup.2 /mm.sup.3) of the outer surface area of a molded catalyst powder to the volume thereof is from 4 to 8; and (6) all points in the interior of the molded catalyst particle are positioned within 0.05 to 0.6 mm from the outer surface thereof. A process for producing the catalyst composition is also disclosed. Further, a process for hydrogenating heavy hydrocarbon oil, which comprises contacting the heavy hydrocarbon oil with the catalyst composition in the presence of hydrogen is disclosed.
摘要翻译： 一种用于重质烃油氢化的催化剂组合物，其中催化剂组合物包含至少一种负载在多孔氧化铝载体上的用于氢化的活性成分，并具有以下特征：（1）其中的孔的总体积为0.4-1.0 ml / g; （2）孔径为5至400埃的孔的平均孔径为60至140纳米; （3）孔径为孔径为5〜400的孔的平均孔径的+/- 25％以内的孔的体积为孔径为孔的体积的60〜98％ 从5到400 ANGSTROM; （4）孔径为400〜5000的孔的体积为整个孔的总体积的2〜9％ （5）成型催化剂粉末的外表面积与其体积的比（mm2 / mm3）为4〜8; 和（6）模塑催化剂颗粒内部的所有点位于距其外表面0.05至0.6mm的范围内。 还公开了一种制备催化剂组合物的方法。 此外，公开了一种用于氢化重质烃油的方法，其包括在氢气存在下使重质烃油与催化剂组合物接触。
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