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    Catalyst composition for hydrogenation of heavy hydrocarbon oil and process for producing the catalyst
    6.
    发明授权
    Catalyst composition for hydrogenation of heavy hydrocarbon oil and process for producing the catalyst 失效
    用于重质烃油氢化的催化剂组合物和用于生产催化剂的方法

    公开(公告)号：US4981832A

    公开(公告)日：1991-01-01

    申请号：US374805

    申请日：1989-07-03

    申请人： Kinya Tawara ,  Kazuyoshi Kudoh ,  Kazushi Usui ,  Tomohiro Yoshinari ,  Shigenori Nakashizu

    发明人： Kinya Tawara ,  Kazuyoshi Kudoh ,  Kazushi Usui ,  Tomohiro Yoshinari ,  Shigenori Nakashizu

    IPC分类号： B01J23/88 ,  B01J23/883 ,  B01J35/02 ,  B01J35/10 ,  C10G45/04 ,  C10G45/06 ,  C10G45/08

    CPC分类号： B01J35/10 ,  B01J23/883 ,  C10G45/04 ,  B01J35/1042 ,  B01J35/1061 ,  B01J35/108

    摘要： A catalyst composition for the hydrogenation of heavy hydrocarbon oil, where the catalyst composition comprises at least one active ingredient for hydrogenation supported on a porous alumina carrier and has the following characteristics: (1) the total volume of the pores therein is from 0.4 to 1.0 ml/g; (2) the mean pore diameter of pores having a pore diameter of from 5 to 400 .ANG. is from 60 to 140 .ANG.; (3) the volume of pores having a pore size within .+-.25% of the mean pore diameter of pores having a pore diameter of from 5 to 400 .ANG. is from 60 to 98% of the volume of pores having a pore diameter of from 5 to 400 .ANG.; (4) the volume of pores having a pore diameter of from 400 to 5000 .ANG. is from 2 to 9% of the total volume of the entire pores; (5) the ratio (mm.sup.2 /mm.sup.3) of the outer surface area of a molded catalyst powder to the volume thereof is from 4 to 8; and (6) all points in the interior of the molded catalyst particle are positioned within 0.05 to 0.6 mm from the outer surface thereof. A process for producing the catalyst composition is also disclosed. Further, a process for hydrogenating heavy hydrocarbon oil, which comprises contacting the heavy hydrocarbon oil with the catalyst composition in the presence of hydrogen is disclosed.

    摘要翻译： 一种用于重质烃油氢化的催化剂组合物，其中催化剂组合物包含至少一种负载在多孔氧化铝载体上的用于氢化的活性成分，并具有以下特征：（1）其中的孔的总体积为0.4-1.0 ml / g; （2）孔径为5至400埃的孔的平均孔径为60至140纳米; （3）孔径为孔径为5〜400的孔的平均孔径的+/- 25％以内的孔的体积为孔径为孔的体积的60〜98％ 从5到400 ANGSTROM; （4）孔径为400〜5000的孔的体积为整个孔的总体积的2〜9％ （5）成型催化剂粉末的外表面积与其体积的比（mm2 / mm3）为4〜8; 和（6）模塑催化剂颗粒内部的所有点位于距其外表面0.05至0.6mm的范围内。 还公开了一种制备催化剂组合物的方法。 此外，公开了一种用于氢化重质烃油的方法，其包括在氢气存在下使重质烃油与催化剂组合物接触。

    Catalyst composition for hydrogenation of heavy hydrocarbon oil and process for producing the catalyst
    7.
    发明授权
    Catalyst composition for hydrogenation of heavy hydrocarbon oil and process for producing the catalyst 失效
    用于重质烃油氢化的催化剂组合物和用于生产催化剂的方法

    公开(公告)号：US5002919A

    公开(公告)日：1991-03-26

    申请号：US394441

    申请日：1989-08-16

    申请人： Hatsutaro Yamazaki ,  Takeshi Tomino ,  Kazushi Usui ,  Tomohiro Yoshinari ,  Takuo Suzuki

    发明人： Hatsutaro Yamazaki ,  Takeshi Tomino ,  Kazushi Usui ,  Tomohiro Yoshinari ,  Takuo Suzuki

    IPC分类号： B01J23/88 ,  B01J23/68 ,  B01J23/85 ,  B01J35/00 ,  B01J35/10 ,  C10G45/04 ,  C10G45/06 ,  C10G45/08

    CPC分类号： B01J35/10 ,  B01J23/683 ,  B01J23/85 ,  C10G45/04 ,  B01J35/002 ,  B01J35/1042 ,  B01J35/1061 ,  B01J35/108

    摘要： A catalyst composition for the hydrogenation of heavy hydrocarbon oil comprising at least one active ingredient for hydrogenation supported on a porous refractory oxide carrier and which has the following characteristics:(1) the mean pore diameter of the pores thereof is in the range of 130 to 250 .ANG.;(2) the volume of pores having a pore diameter within .+-.30 .ANG. of the mean pore diameter is in the range of from not less than 30% to less than 60% of the total volume of the pores;(3) the volume of pores having a pore diameter of not larger than 80 .ANG. is not more than 13% of the total volume of the pores;(4) the volume of pores having a pore diameter of not smaller than 350 .ANG. is not more than 25% of the total volume of the pores; and(5) the ratio (mm.sup.2 /mm.sup.3) of the outer surface of a molded catalyst particle to the volume thereof is in the range of 3 to 8. There are also disclosed a process for producing the catalyst composition and a process for hydrogenating heavy hydrocarbon oil, the latter of which comprise contacting heavy hydrocarbon oil with the catalyst composition in the presence of hydrogen.

    摘要翻译： 一种用于氢化重烃油的催化剂组合物，其包含至少一种负载在多孔难熔氧化物载体上的用于氢化的活性成分，并且具有以下特征：（1）其孔的平均孔径在130〜 250 ANGSTROM; （2）孔径在平均孔径的+/-30范围内的孔的体积在不小于孔的总体积的30％至小于60％的范围内; （3）孔径不大于80的孔的体积不大于孔的总体积的13％; （4）孔径不小于350的孔的体积不大于孔的总体积的25％; 和（5）模塑催化剂颗粒的外表面与其体积的比（mm2 / mm3）在3至8的范围内。还公开了一种制备该催化剂组合物的方法和一种氢化重质 烃油，其后者包括在氢的存在下使重质烃油与催化剂组合物接触。

    SUSTAINED RELEASE PREPARATION
    8.
    发明申请
    SUSTAINED RELEASE PREPARATION 审中-公开
    持续发布准备

    公开(公告)号：US20110045028A1

    公开(公告)日：2011-02-24

    申请号：US12516536

    申请日：2007-11-29

    申请人： Satoshi Iinuma ,  Yoshie Iinuma ,  Tomohiro Yoshinari ,  Tsuneaki Tottori

    发明人： Satoshi Iinuma ,  Yoshie Iinuma ,  Tomohiro Yoshinari ,  Tsuneaki Tottori

    IPC分类号： A61K31/513 ,  A61K9/00 ,  A61P7/02 ,  A61P9/10

    CPC分类号： A61K31/506 ,  A61K9/2018 ,  A61K9/2054

    摘要： Disclosed is a sustained-release preparation which is prepared by shaping a granule comprising a blood coagulation factor Xa inhibitor and a mixture of at least two hydrophilic polymers. Also disclosed is a pharmaceutical composition comprising a combination of the sustained-release preparation and an immediate release preparation comprising a blood coagulation factor Xa inhibitor. It becomes possible to provide a controlled release preparation comprising a blood coagulation factor Xa inhibitor for the prevention or treatment of thrombosis, which can control the activity of blood coagulation factor Xa for a long term and is excellent in convenience and compliance. It is also becomes possible to provide a method for producing the controlled release preparation.

    摘要翻译： 公开了一种缓释制剂，其通过使包含凝血因子Xa抑制剂和至少两种亲水性聚合物的混合物的颗粒成形而制备。 还公开了包含缓释制剂和包含凝血因子Xa抑制剂的速释制剂的组合的药物组合物。 可以提供一种控制释放制剂，其包含凝血因子Xa抑制剂，用于预防或治疗血栓形成，其可以长期控制凝血因子Xa的活性，并且方便性和顺应性优异。 也可以提供一种制备控释制剂的方法。

    Solid preparation
    9.
    发明申请
    Solid preparation 审中-公开
    固体制剂

    公开(公告)号：US20090208584A1

    公开(公告)日：2009-08-20

    申请号：US11921664

    申请日：2006-06-09

    申请人： Tomohiro Yoshinari ,  Yutaka Ebisawa ,  Hiroshi Suzuki

    发明人： Tomohiro Yoshinari ,  Yutaka Ebisawa ,  Hiroshi Suzuki

    IPC分类号： A61K9/14 ,  A61K47/38 ,  A61K31/538

    CPC分类号： A61K9/2095 ,  A61K9/1623 ,  A61K9/1652 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2866 ,  A61K31/536

    摘要： The solid preparation of the present invention aims at providing a solid preparation superior in the stability during production and preservation even when a poorly water-soluble substance having a low melting point is contained in a large amount, and also superior in the disintegration property and release property of a poorly water-soluble substance having a low melting point, after oral administration, and is characterized by the following 1) to 3): 1) containing a poorly water-soluble substance having a low melting point, a saccharide, and a cellulose selected from a crystalline cellulose and a low-substituted hydroxypropylcellulose, 2) a saccharide/cellulose weight ratio exceeding 2, and 3) a cellulose content of not less than 5 wt %.

    摘要翻译： 本发明的固体制剂的目的在于提供即使在大量含有低熔点的难溶性水溶性物质的情况下，在制造和保存中的稳定性方面也优异的固体制剂，并且还具有优异的崩解性和脱模性 口服后具有低熔点的水溶性差的物质的性质，其特征在于以下1）〜3）：1）含有低熔点的水难溶性物质，糖类和 选自结晶纤维素和低取代羟丙基纤维素的纤维素，2）糖/纤维素重量比超过2，和3）纤维素含量不小于5重量％。