公开(公告)号：US12109274B2

公开(公告)日：2024-10-08

申请号：US15760686

申请日：2016-09-19

Applicant: ModernaTX, Inc.

Inventor： Gabor Butora ,  Andrew W. Fraley ,  Edward John Miracco ,  Jennifer Nelson ,  Amy Rhoden Smith ,  Matthew Stanton ,  Brian R. Fritz

IPC: A61K48/00 ,  C07F9/6558 ,  C07F9/6561 ,  C07H21/02 ,  C12N15/67

CPC classification number: A61K48/0066 ,  C07F9/65586 ,  C07F9/65616 ,  C07H21/02 ,  C12N15/67

Abstract: The invention features polynucleotides encoding a polypeptide including a 3′-stabilizing region and having increased stability compared to wild-type polynucleotides.