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    Enzymatic production of acyl flavonoid derivatives
    1.
    发明申请
    Enzymatic production of acyl flavonoid derivatives 审中-公开
    酰基类黄酮衍生物的酶促生产

    公开(公告)号：US20060115880A1

    公开(公告)日：2006-06-01

    申请号：US10537627

    申请日：2003-11-22

    申请人： Mohamed Ghoul ,  Jean-Marc Engasser ,  Philippe Moussou ,  Gilles Pauly ,  Melika Ardhaoui ,  Aude Falcimaigne

    发明人： Mohamed Ghoul ,  Jean-Marc Engasser ,  Philippe Moussou ,  Gilles Pauly ,  Melika Ardhaoui ,  Aude Falcimaigne

    IPC分类号： C12P17/06

    CPC分类号： C12P7/62 ,  C12P17/06

    摘要： Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.

    摘要翻译： 公开了一种用于酶促合成类黄酮和类黄酮衍生物的酯的方法，根据该方法，产生含有有机溶剂，糖基化黄酮或苷元类黄酮，酰基供体和酶催化剂的反应介质，b） 在反应期间任选地加入类黄酮和/或酰基供体，和c）将所得酯与酶微粒和溶剂分离。 本发明的方法的特征在于将反应期间形成的水和/或醇的浓度保持在150mM以下。 有利地，在反应期间，反应介质中类黄酮与酰基供体的摩尔比保持在0.01至20.00的范围内。