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    Enzymatic production of acyl flavonoid derivatives
    2.
    发明申请
    Enzymatic production of acyl flavonoid derivatives 审中-公开
    酰基类黄酮衍生物的酶促生产

    公开(公告)号：US20060115880A1

    公开(公告)日：2006-06-01

    申请号：US10537627

    申请日：2003-11-22

    申请人： Mohamed Ghoul ,  Jean-Marc Engasser ,  Philippe Moussou ,  Gilles Pauly ,  Melika Ardhaoui ,  Aude Falcimaigne

    发明人： Mohamed Ghoul ,  Jean-Marc Engasser ,  Philippe Moussou ,  Gilles Pauly ,  Melika Ardhaoui ,  Aude Falcimaigne

    IPC分类号： C12P17/06

    CPC分类号： C12P7/62 ,  C12P17/06

    摘要： Disclosed is a method for enzymatic synthesis of esters of flavonoid and flavonoid derivatives, according to which a reaction medium containing an organic solvent, a glycosylated flavonoid or aglycon flavonoid, an acyl group donor, and an enzymatic catalyst is produced, b) additional quantities of flavonoid and/or acyl donor are optionally added during the reaction, and c) the obtained esters are separated from the enzymatic particles and the solvent. The inventive method is characterized by maintaining the concentration of water and/or alcohol which are formed during the reaction to below 150 mM. Advantageously, the molar ratio of flavonoid to acyl donor in the reaction medium is maintained in the range from 0.01 to 20.00 during the reaction.

    摘要翻译： 公开了一种用于酶促合成类黄酮和类黄酮衍生物的酯的方法，根据该方法，产生含有有机溶剂，糖基化黄酮或苷元类黄酮，酰基供体和酶催化剂的反应介质，b） 在反应期间任选地加入类黄酮和/或酰基供体，和c）将所得酯与酶微粒和溶剂分离。 本发明的方法的特征在于将反应期间形成的水和/或醇的浓度保持在150mM以下。 有利地，在反应期间，反应介质中类黄酮与酰基供体的摩尔比保持在0.01至20.00的范围内。

    Cosmetic preparations containing PTH fragments
    3.
    发明授权
    Cosmetic preparations containing PTH fragments 有权
    包含PTH片段的化妆品

    公开(公告)号：US09387235B2

    公开(公告)日：2016-07-12

    申请号：US11570614

    申请日：2005-06-06

    申请人： Philippe Moussou ,  Louis Danoux ,  Vincent Bardey ,  Christine Jeanmaire ,  Gilles Pauly

    发明人： Philippe Moussou ,  Louis Danoux ,  Vincent Bardey ,  Christine Jeanmaire ,  Gilles Pauly

    IPC分类号： A61K38/00 ,  C07K16/00 ,  A61K38/29 ,  A61K8/64 ,  A61K38/07 ,  A61Q7/00 ,  A61Q19/06 ,  A61Q19/08

    CPC分类号： A61K38/29 ,  A61K8/64 ,  A61K38/07 ,  A61Q7/00 ,  A61Q19/06 ,  A61Q19/08

    摘要： A cosmetic or pharmaceutical composition includes a peptide parathyroid hormone fragment, derivatives thereof, salts thereof, and combinations thereof, where the peptide fragment conforms to the structure R1-NH-AA-R2 where R1 is selected from the group consisting of —H, a linear or branched, saturated or unsaturated acyl group having from 1 to 24 carbon atoms optionally functionalized with an —OH, —SH, —COOH or —CONH2 group, or a sterol group which is bonded by a functional group with the peptide; where R2 is —OH, —OH functionalized by a linear or branched, saturated or unsaturated alkyl group having from 1 to 24 carbon atoms, or a sterol group; and where AA corresponds completely or partially to the sequence of amino acids according to SEQ ID No. 1 corresponding to the PTH (28 to 34) region.

    摘要翻译： 化妆品或药物组合物包括肽甲状旁腺激素片段，其衍生物，其盐及其组合，其中肽片段符合结构R1-NH-AA-R2，其中R1选自-H，a 任选被-OH，-SH，-COOH或-CONH 2基官能化的具有1至24个碳原子的直链或支链，饱和或不饱和的酰基，或通过官能团与该肽键合的固醇基团; 其中R2是-OH，由具有1至24个碳原子的直链或支链，饱和或不饱和的烷基或甾醇基官能化的-OH; 并且其中AA对应于根据对应于PTH（28至34）区域的SEQ ID No.1的氨基酸序列的完全或部分对应。

    Method for producing glycogens for use in cosmetics by culturing yeast cells in two phases
    8.
    发明授权
    Method for producing glycogens for use in cosmetics by culturing yeast cells in two phases 失效
    通过两相培养酵母细胞生产用于化妆品的糖原的方法

    公开(公告)号：US6146857A

    公开(公告)日：2000-11-14

    申请号：US43830

    申请日：1998-06-15

    申请人： Gilles Pauly ,  Marc Pauly ,  Jean-Marc Engasser ,  Mohamed Ghoul

    发明人： Gilles Pauly ,  Marc Pauly ,  Jean-Marc Engasser ,  Mohamed Ghoul

    IPC分类号： A61K8/00 ,  A61K8/11 ,  A61K8/72 ,  A61K8/73 ,  A61K8/99 ,  A61Q17/04 ,  A61Q19/00 ,  C08B37/18 ,  C12N1/00 ,  C12N1/06 ,  C12N1/14 ,  C12P19/04 ,  C12R1/86 ,  A61K7/035 ,  C12P1/02

    CPC分类号： A61K8/73 ,  A61Q19/00 ,  C12N1/063 ,  C12P19/04 ,  A61Q17/04 ,  Y10S435/911 ,  Y10S435/921 ,  Y10S435/94

    摘要： A process is provided for the production of glycogens or an extract rich in glycogens from yeast cells, and a cosmetic composition containing them. A given quantity of yeast cells, from a specific culture or recovered as residues of a fermentation process, is subjected to an operation of enrichment in intracellular glycogens by culturing in two phases in the presence of a carbon source. The metabolism of the yeast cells is then stopped. The membranes of the yeast cells are then at least partially disintegrated to free intracellular substances, and the freed intracellular substances are subjected to at least one precipation to precipitate glycogens. A cosmetic composition comprising the glycogens is formulated in admixture with a dermatologically acceptable excipient.

    摘要翻译： PCT No.PCT / FR96 / 02008 Sec。 371日期1998年6月15日第 102（e）1998年6月15日PCT PCT 1996年12月13日PCT公布。 公开号WO97 / 21828 日期1996年6月19日提供了用于从酵母细胞中制备糖原或富含糖原的提取物的方法和含有它们的化妆品组合物的方法。 给定量的来自特定培养物的酵母细胞或作为发酵过程的残留物回收的酵母细胞通过在碳源的存在下在两相中培养来进行细胞内糖原的富集操作。 然后停止酵母细胞的代谢。 然后将酵母细胞的膜至少部分地分解成游离细胞内物质，并且释放的细胞内物质经历至少一个沉淀以沉淀糖原。 含有糖原的化妆品组合物与皮肤病学可接受的赋形剂混合配制。