公开(公告)号：US09090911B2

公开(公告)日：2015-07-28

申请号：US14304919

申请日：2014-06-14

Applicant: Monash University

Inventor： Scott Leslie O'Neill ,  Conor James McMeniman ,  Karyn Nicole Johnson ,  Elizabeth Ann McGraw ,  Luciano A. Moreira ,  Peter Anthony Ryan ,  Brian Herbert Kay ,  Jeremy Colin Brownlie

IPC: C12N1/00 ,  A01N63/00 ,  A01N65/00 ,  A61K39/00 ,  A61K39/02 ,  C12N15/87 ,  A01K67/033 ,  C12N15/01 ,  C12R1/01

CPC classification number: C12N15/87 ,  A01K67/033 ,  A01K67/0337 ,  A01K2227/70 ,  A01K2227/706 ,  A01K2267/02 ,  A01N63/00 ,  C12N15/01 ,  C12R1/01

Abstract: A modified arthropod, an arthropod-modifying bacterium, and use thereof as an agent for control of diseases transmitted by arthropods, particularly mosquitoes, is provided. More specifically, an isolated arthropod-adapted Wolbachia bacterium capable of modifying one or more biological properties of a mosquito host is provided. The modified arthropod may be characterized as having a shortened life-span, a reduced ability to transmit disease, a reduced susceptibility to a pathogen, a reduced fecundity, and/or a reduced ability to feed from a host, when compared to a corresponding wild-type arthropod.

Abstract translation: 提供了一种改良的节肢动物，节肢动物修饰细菌及其作为控制由节肢动物，特别是蚊子传播的疾病的药剂的用途。 更具体地，提供能够改变蚊子宿主的一种或多种生物学特性的分离的节肢动物适应的沃尔巴克氏杆菌细菌。 修饰的节肢动物的特征可以在于与相应的野生型相比具有缩短的寿命，降低的传播能力，降低的对病原体的易感性，降低的繁殖力和/或降低的从宿主进食的能力 型节肢动物

公开(公告)号：US20140298501A1

公开(公告)日：2014-10-02

申请号：US14304919

申请日：2014-06-14

Applicant: Monash University

Inventor： Scott Leslie O'Neill ,  Conor James McMeniman ,  Karyn Nicole Johnson ,  Elizabeth Ann McGraw ,  Luciano A. Moreira ,  Peter Anthony Ryan ,  Brian Herbert Kay ,  Jeremy Colin Brownlie

IPC: C12N15/87 ,  A01K67/033

CPC classification number: C12N15/87 ,  A01K67/033 ,  A01K67/0337 ,  A01K2227/70 ,  A01K2227/706 ,  A01K2267/02 ,  A01N63/00 ,  C12N15/01 ,  C12R1/01

Abstract: A modified arthropod, an arthropod-modifying bacterium, and use thereof as an agent for control of diseases transmitted by arthropods, particularly mosquitoes, is provided. More specifically, an isolated arthropod-adapted Wolbachia bacterium capable of modifying one or more biological properties of a mosquito host is provided. The modified arthropod may be characterized as having a shortened life-span, a reduced ability to transmit disease, a reduced susceptibility to a pathogen, a reduced fecundity, and/or a reduced ability to feed from a host, when compared to a corresponding wild-type arthropod.

Abstract translation: 提供了一种改良的节肢动物，节肢动物修饰细菌及其作为控制由节肢动物，特别是蚊子传播的疾病的药剂的用途。 更具体地，提供能够改变蚊子宿主的一种或多种生物学特性的分离的节肢动物适应的沃尔巴克氏杆菌细菌。 修饰的节肢动物的特征可以在于与相应的野生型相比具有缩短的寿命，降低的传播能力，降低的对病原体的易感性，降低的繁殖力和/或降低的从宿主进食的能力 型节肢动物