公开(公告)号：US20220403343A1

公开(公告)日：2022-12-22

申请号：US17779275

申请日：2019-11-26

Applicant: THE UNIVERSITY OF WESTERN AUSTRALIA ,  MONASH UNIVERSITY

Inventor： Ryan LISTER ,  Sam BUCKBERRY ,  Jose POLO ,  Xiaodong LIU

IPC: C12N5/074

Abstract: The present invention relates to methods for producing an induced pluripotent stem (iPSC), the method comprising the following steps in order: culturing a somatic cell in a first culture condition adapted to promote the reprogramming of the cell towards a pluripotent state; culturing the cell in a second culture condition adapted to promote a hypomethylated DNA state in the cell; and culturing the cell in a third culture condition adapted to promote a primed pluripotent state, thereby producing an iPSC from a somatic cell. The invention also relates to cells and compositions resulting from those methods.

公开(公告)号：US20220162550A1

公开(公告)日：2022-05-26

申请号：US17534594

申请日：2021-11-24

Applicant: Monash University

Inventor： Jose POLO ,  Xiaodong LIU ,  Jia Ping TAN

IPC: C12N5/0735

Abstract: The present invention relates to stem cells derived from a multi-layered cellular structure or blastocyst structure, compositions comprising the same, and methods for obtaining the same.

公开(公告)号：US20240209323A1

公开(公告)日：2024-06-27

申请号：US18601343

申请日：2024-03-11

Applicant: Monash University

Inventor： Jose POLO ,  Xiaodong LIU ,  Jia Ping TAN

IPC: C12N5/074

CPC classification number: C12N5/0696 ,  C12N5/0607 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/415 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2506/03 ,  C12N2510/02

Abstract: The invention provides methods and compositions for producing a multi-layered cellular structure or blastocyst-like structure from a cell population of reprogrammed somatic cells.

公开(公告)号：US20220259566A1

公开(公告)日：2022-08-18

申请号：US17534592

申请日：2021-11-24

Applicant: Monash University

Inventor： Jose POLO ,  Xiaodong LIU ,  Jia Ping TAN

IPC: C12N5/074

Abstract: The invention provides methods and compositions for producing a multi-layered cellular structure or blastocyst-like structure from a cell population of reprogrammed somatic cells.