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公开(公告)号：US20120251531A1
公开(公告)日：2012-10-04
申请号：US13431489
申请日：2012-03-27
IPC分类号： A61K39/395 , C07K19/00 , C07K16/28
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/52 , C07K2317/56 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/30 , Y10S435/81
摘要： The invention relates to engineered polypeptides comprising Fc variants and their uses. More specifically, Fc variants are described exhibiting reduced effector function. These variants cause a benefit for a patient suffering from a disease which could be treated with an antibody for which it is desirable to reduce the effector function elicited by antibodies.
摘要翻译： 本发明涉及包含Fc变体及其用途的工程化多肽。 更具体地，描述了表现出降低的效应子功能的Fc变体。 这些变体对患有可以用希望减少由抗体引起的效应子功能的抗体治疗的疾病患者造成益处。
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公开(公告)号：US08969526B2
公开(公告)日：2015-03-03
申请号：US13431489
申请日：2012-03-27
IPC分类号： C07K16/00 , A61K39/395 , A61K39/40 , C07K1/00
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/52 , C07K2317/56 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/30 , Y10S435/81
摘要： The invention relates to engineered polypeptides comprising Fc variants and their uses. More specifically, Fc variants are described exhibiting reduced effector function. These variants cause a benefit for a patient suffering from a disease which could be treated with an antibody for which it is desirable to reduce the effector function elicited by antibodies.
摘要翻译： 本发明涉及包含Fc变体及其用途的工程化多肽。 更具体地，描述了表现出降低的效应子功能的Fc变体。 这些变体对患有可以用希望减少由抗体引起的效应子功能的抗体治疗的疾病患者造成益处。
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公开(公告)号：US20080248510A1
公开(公告)日：2008-10-09
申请号：US12056310
申请日：2008-03-27
申请人： Ulrich Brinkmann , Peter Bruenker , Claudia Ferrara Koller , Martin Lanzendoerfer , Joerg Thomas Regula , Tilman Schlothauer , Stefan Seeber , Anne Zeck
发明人： Ulrich Brinkmann , Peter Bruenker , Claudia Ferrara Koller , Martin Lanzendoerfer , Joerg Thomas Regula , Tilman Schlothauer , Stefan Seeber , Anne Zeck
IPC分类号： G01N33/53 , G01N33/566 , C12P21/04 , C07K14/00
CPC分类号： C07K14/70535 , G01N2333/70535
摘要： The present invention relates to the field of human immunoglobulin receptors, specifically the glycostructure of a human Fc gamma receptor IIIa recombinantly expressed in human embryonic kidney cells and Chinese hamster ovary cells.
摘要翻译： 本发明涉及人免疫球蛋白受体的领域，特别涉及人胚胎肾细胞和中国仓鼠卵巢细胞中重组表达的人Fcγ受体IIIa的糖结构。
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公开(公告)号：US20110045510A1
公开(公告)日：2011-02-24
申请号：US12934678
申请日：2009-03-31
IPC分类号： G01N33/543 , G01N33/566
CPC分类号： G01N33/566 , G01N33/74 , G01N2333/65
摘要： The current invention reports an immunoassay for the determination of PEGylated insulin-like-growth-factor employing an anti-(polyethylene glycol) antibody and an anti-digoxygenin antibody for the detection of an insulin-like-growth-factor/insulin-like-growth-factor-binding-protein-complex.
摘要翻译： 本发明报道了使用抗（聚乙二醇）抗体和抗 - 地高辛素抗体测定胰岛素样生长因子/胰岛素样生长因子的聚乙二醇化胰岛素样生长因子的免疫测定， 生长因子结合蛋白复合物。
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