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1.发明申请WHOLE-CELL CATALYTIC SYSTEM COMPRISING A HYDANTOINASE, A RACEMASE AND A CARBAMOYLASE 审中-公开包含HYDANTOINASE，RACEMASE和CARBAMOYLASE的全细胞催化体系公开(公告)号：US20100143981A1
公开(公告)日：2010-06-10
申请号：US12517504
申请日：2007-12-04
申请人： Monika Rusnak-Müller , Oliver May , Petrus Johannes Hermsen , Henricus Martinus Maria Gerardus Straatman , Wolfgang Skranc , Wilhelmus Hubertus Joseph Boesten , Dannis Heemskerk , Ben De Lange , Georgios Sarakinos
发明人： Monika Rusnak-Müller , Oliver May , Petrus Johannes Hermsen , Henricus Martinus Maria Gerardus Straatman , Wolfgang Skranc , Wilhelmus Hubertus Joseph Boesten , Dannis Heemskerk , Ben De Lange , Georgios Sarakinos
IPC分类号： C12P13/04 , C12N1/21 , C12N15/74 , C07D233/72 , C07C205/01
CPC分类号： C12P13/04 , C07C229/30 , C07C229/32 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/74 , C07D233/78 , C12P13/22 , C12P13/222 , C12P17/10 , C12P41/00 , C12P41/009
摘要： The present invention relates to a whole cell catalytic system for the preparation of an enantiomerically enriched α-amino acid from a corresponding hydantoin wherein hydantoinase, L-carbamoylase and hydantoin racemase are coexpressed in a recombinant micro-organism wherein the genes coding for these three enzymes are located on a single replicon. The present invention further relates to the use of such a whole cell catalytic system according in the preparation of an enantiomerically enriched L-α-amino acid from a corresponding hydantoin.
摘要翻译： 本发明涉及一种用于从相应的乙内酰脲制备对映异构体富集的α-氨基酸的全细胞催化体系，其中将乙内酰脲酶，L-氨基甲酰基酶和乙内酰脲消旋酶共表达于重组微生物中，其中编码这三种酶的基因 位于单个复制器上。 本发明还涉及根据从对应的乙内酰脲制备对映体富集的L-α-氨基酸的这种全细胞催化体系的用途。
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公开(公告)号：US08420683B2
公开(公告)日：2013-04-16
申请号：US12601304
申请日：2008-06-03
IPC分类号： A61K31/4166 , C07D233/76
CPC分类号： C07D209/42 , C07D209/52 , C07D233/76 , C07D233/78 , C07D233/80
摘要： The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.
摘要翻译： 本发明涉及5-取代的乙内酰脲，制备5-取代的乙内酰脲的方法和5-取代的乙内酰脲在制备对映体富集的α-氨基酸中的用途。 此外，本发明涉及使用新的5-取代的乙内酰脲制备药物活性产物如培哚普利和雷米普利。
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公开(公告)号：US20100174092A1
公开(公告)日：2010-07-08
申请号：US12601304
申请日：2008-06-03
IPC分类号： C07D235/02 , C07D233/72
CPC分类号： C07D209/42 , C07D209/52 , C07D233/76 , C07D233/78 , C07D233/80
摘要： The present invention relates to 5-substituted hydantoins, a process for the preparation of 5-substituted hydantoins and the use of 5-substituted hydantoins in the preparation of enantiomerically enriched α-amino acids. Furthermore, the present invention relates to the preparation of pharmaceutically active products such as perindopril and ramipril using the novel 5-substituted hydantoins.
摘要翻译： 本发明涉及5-取代的乙内酰脲，制备5-取代的乙内酰脲的方法和5-取代的乙内酰脲在制备对映体富集的α-氨基酸中的用途。 此外，本发明涉及使用新的5-取代的乙内酰脲制备药物活性产物如培哚普利和雷米普利。
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4.发明授权Process of preparing L and D .alpha.-amino acids by enzyme treatment of DL-.alpha.-amino acid amide 失效通过酶处理DL- {60-氨基酸酰胺制备L和D {60-氨基酸的方法
公开(公告)号：US4080259A
公开(公告)日：1978-03-21
申请号：US756969
申请日：1977-01-04
CPC分类号： C12P13/04 , C12N9/80 , Y10S435/874 , Y10S435/877
摘要： A method of producing enzyme preparations having L-.alpha.-amino acyl amidase activity comprising cultivating a micro-organism selected from the group consisting of Pseudomonas putida, Pseudomonas reptilivora, and Pseudomonas arvilla in a nutrient medium and separating an enzyme preparation from said nutrient medium.A process of preparing L-.alpha.-amino acid and D-.alpha.-amino acid amide from DL-.alpha.-amino acid amide by contacting said DL-.alpha.-amino acid amide with an enzyme preparation obtained by cultivating a micro-organism selected from the group consisting of Pseudomonas putida, Pseudomonas reptilivora, and Pseudomonas arvilla in the presence of a nutrient medium and separating the L-.alpha.-amino acid and D-.alpha.-amino acid amide thus formed.
摘要翻译： 一种生产具有L-α-氨基酰基酰胺酶活性的酶制剂的方法，包括在营养培养基中培养选自恶臭假单胞菌，复制假单胞菌和假单胞菌的微生物，并从所述营养培养基中分离酶制剂。
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5.发明授权Polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same 失效具有α-H-α-氨基酸酰胺消旋酶活性的多肽和编码其的核酸公开(公告)号：US07371555B2
公开(公告)日：2008-05-13
申请号：US10732011
申请日：2003-12-09
申请人： Wilhelmus Hubertus Joseph Boesten , Petronella Catharina Raemakers-Franken , Theodorus Sonke , Gerrit Jan Willem Euverink , Pieter Grijpstra
发明人： Wilhelmus Hubertus Joseph Boesten , Petronella Catharina Raemakers-Franken , Theodorus Sonke , Gerrit Jan Willem Euverink , Pieter Grijpstra
CPC分类号： C12P41/007 , C07K2319/00 , C12N9/90 , C12P13/02 , C12P13/04
摘要： The invention relates to isolated polypeptides having α-H-α-amino acid amide racemase activity and nucleic acids encoding the same. The invention also relates to vectors and host cells comprising the nucleic acids according to the invention. The invention also relates to methods of producing and using the polypeptides according to the invention. The invention also relates to a method for isolating polypeptides having α-H-α-amino acid amide racemase activity, for isolating nucleic acids encoding the same and for isolating microorganisms comprising polypeptides having α-H-α-amino acid amide racemase activity. The invention also relates to new microorganisms comprising polypeptides having α-H-α-amino acid amide racemase activity.
摘要翻译： 本发明涉及具有α-H-α-氨基酸酰胺消旋酶活性的分离多肽和编码该多肽的核酸。 本发明还涉及包含根据本发明的核酸的载体和宿主细胞。 本发明还涉及生产和使用根据本发明的多肽的方法。 本发明还涉及用于分离具有α-H-α-氨基酸酰胺消旋酶活性的多肽的方法，用于分离编码该多肽的核酸，并用于分离包含具有α-H-α-氨基酸酰胺消旋酶活性的多肽的微生物。 本发明还涉及包含具有α-H-α-氨基酸酰胺消旋酶活性的多肽的新微生物。
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6.发明授权Process for the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives 有权（4-羟基-6-氧代 - 四氢吡喃-2-基）乙腈及其衍生物的制备方法公开(公告)号：US07423162B2
公开(公告)日：2008-09-09
申请号：US10554294
申请日：2004-04-28
IPC分类号： C07D309/30
CPC分类号： C07D309/30
摘要： The invention relates to a process for the preparation of (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile from 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one, wherein X stands for a leaving group, by reacting 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one with a cyanide ion in water and by subsequent lowering of the pH to a pH between 0 and 5. (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile and other compounds obtainable from (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile may suitably be used in the preparation of a pharmaceutical preparation, more in particular in the preparation of statins, more in particular in the preparation of Atorvastatine or a salt thereof, for instance its calcium salt. The invention also relates to (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile and other compounds obtainable therefrom.
摘要翻译： 本发明涉及从6-X取代的甲基-4-羟基 - 四氢 - 吡喃-2-酮制备（4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙腈的方法， 其中X代表离去基团，通过使6-X取代的甲基-4-羟基 - 四氢 - 吡喃-2-酮与氰化物离子在水中反应，随后将pH降低至0至5之间的pH。 （4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙腈和从（4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙腈获得的其它化合物可适当地用于制备 药物制剂，更特别是制备他汀类药物，更特别是制备阿托伐他汀或其盐，例如其钙盐。 本发明还涉及（4-羟基-6-氧代 - 四氢 - 吡喃-2-基） - 乙腈及其可得的其它化合物。
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7.发明申请PROCESS FOR THE PREPARATION OF A HYDROXY-AROMATIC RESIN; HYDROXY-AROMATIC RESIN, AND MODIFICATION THEREOF 审中-公开制备羟基芳族树脂的方法; 羟基芳香树脂及其改性公开(公告)号：US20120022211A1
公开(公告)日：2012-01-26
申请号：US13248672
申请日：2011-09-29
申请人： Jozef Johannes Catherina Jacobus BOONEN , Wilhelmus Hubertus Joseph Boesten , Renier Henricus Maria Kierkels , Mark Martinus Maria Janssen , Rudolfus Antonius Theodorus Maria Van Benthem
发明人： Jozef Johannes Catherina Jacobus BOONEN , Wilhelmus Hubertus Joseph Boesten , Renier Henricus Maria Kierkels , Mark Martinus Maria Janssen , Rudolfus Antonius Theodorus Maria Van Benthem
IPC分类号： C09D161/12 , C09J161/12 , C08G14/08 , C08G8/04 , C08G14/10
CPC分类号： C08G12/36 , C08G8/04 , C08G12/32 , C09D161/24 , C09D161/28
摘要： The invention relates to a hydroxy-aromatic resin, prepared by bringing together and reacting a hydroxy-aromatic compound and glyoxylic acid.The invention further relates to use of the resin in adhesives, laminates, and coatings.
摘要翻译： 本发明涉及通过使羟基 - 芳族化合物和乙醛酸结合在一起而制备的羟基 - 芳族树脂。 本发明还涉及在粘合剂，层压材料和涂料中使用树脂。
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8.发明申请PROCESS FOR THE PREPARATION OF A HYDROXY-AROMATIC RESIN: HYDROXY-AROMATIC RESIN, AND MODIFICATION THEREOF 审中-公开羟基芳族树脂的制备方法：羟基芳族树脂及其改性公开(公告)号：US20090326164A1
公开(公告)日：2009-12-31
申请号：US12301679
申请日：2007-06-01
申请人： Jozef Johannes Catherina Jacobus Boonen , Wilhelmus Hubertus Joseph Boesten , Renier Henricus Maria Kierkels , Mark Martinus Maria Janssen , Rudolfus Antonius Theodorus Maria Van Benthem
发明人： Jozef Johannes Catherina Jacobus Boonen , Wilhelmus Hubertus Joseph Boesten , Renier Henricus Maria Kierkels , Mark Martinus Maria Janssen , Rudolfus Antonius Theodorus Maria Van Benthem
IPC分类号： C08G8/04
CPC分类号： C08G12/36 , C08G8/04 , C08G12/32 , C09D161/24 , C09D161/28
摘要： The invention relates to a hydroxy-aromatic resin, prepared by bringing together and reacting a hydroxy-aromatic compound and glyoxylic acid,The invention further relates to use of the resin in adhesives, laminates, and coatings.
摘要翻译： 本发明涉及通过使羟基 - 芳族化合物和乙醛酸聚合和反应制备的羟基 - 芳族树脂。本发明还涉及在粘合剂，层压材料和涂料中使用该树脂。
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公开(公告)号：US07713724B2
公开(公告)日：2010-05-11
申请号：US10515800
申请日：2003-05-23
申请人： Wilhelmus Hubertus Joseph Boesten , Joannes Gerardus Theodorus Kierkels , Friso Bernard Jan Assema , Luis Miguel Ruiz Pérez , Dolores González Pacanowska , Jesús González López , Santiago De La Escalera Hueso
发明人： Wilhelmus Hubertus Joseph Boesten , Joannes Gerardus Theodorus Kierkels , Friso Bernard Jan Assema , Luis Miguel Ruiz Pérez , Dolores González Pacanowska , Jesús González López , Santiago De La Escalera Hueso
摘要： The invention relates to isolated polypeptides with hydantoin recemase activity, that do not suffer from substrate inhibition. Such polypeptides arc for instance isolated polypeptides with at least 87% identity with SEQ ID: NO. 2 or SEQ ED: NO. 4. The invention also relates to nucleic acid sequences encoding these polypeptides. The invention also relates to processes for the racemisation of enantiomerically enriched hydantoin compounds and to processes for the preparation of enantiomarically enriched I)-or I-α amino acids.
摘要翻译： 本发明涉及具有乙内酰脲接收活性的分离的多肽，其不受底物抑制。 这样的多肽例如与SEQ ID NO：具有至少87％同一性的分离的多肽。 2或SEQ ED：NO。 本发明还涉及编码这些多肽的核酸序列。 本发明还涉及对映体富集的乙内酰脲化合物的外消旋化方法以及制备对映体富集的I） - 或I-α氨基酸的方法。
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公开(公告)号：US20080249329A1
公开(公告)日：2008-10-09
申请号：US12088159
申请日：2006-09-26
IPC分类号： C07C229/52
CPC分类号： C07C67/10 , C07C229/36 , C07C69/78
摘要： The invention relates to a sulphonic acid salt of an amino acid alkyl ester The invention further relates to a process for the esterification of an organic acid into the corresponding organic acid ester comprising bringing the organic acid into contact with a strong acid and a solution comprising dialkylcarbonate in a reaction mixture. The invention further relates to the use of a sulphonic acid salt of an amino acid alkyl ester in the synthesis of a β-lactam antibiotic.
摘要翻译： 本发明涉及氨基酸烷基酯的磺酸盐本发明还涉及将有机酸酯化成相应的有机酸酯的方法，包括使有机酸与强酸和包含二烷基碳酸酯的溶液接触 在反应混合物中。 本发明还涉及氨基酸烷基酯的磺酸盐在β-内酰胺抗生素的合成中的用途。
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