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1.发明申请Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone 失效具有减毒的日本脑炎病毒基因的减毒嵌合黄病毒作为骨架公开(公告)号：US20090104702A1
公开(公告)日：2009-04-23
申请号：US12292518
申请日：2008-11-20
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
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2.发明授权Attenuated chimeric flavivirus bearing attenuated Japanese encephalitis virus gene as backbone 失效具有减毒的日本脑炎病毒基因的减毒嵌合黄病毒作为骨架公开(公告)号：US07749734B2
公开(公告)日：2010-07-06
申请号：US11793277
申请日：2005-12-22
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
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3.发明申请Attenuated Chimeric Flavivirus Bearing Attenuated Japanese Encephalitis Virus Gene as Backbone 失效减毒的嵌合黄病毒携带减毒的日本脑炎病毒基因作为骨干公开(公告)号：US20080138363A1
公开(公告)日：2008-06-12
申请号：US11793277
申请日：2005-12-22
申请人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Morita Kouichi , Takeshi Nabeshima , Shinichi Miyake , Toshiuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
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4.发明授权Attenuated chimeric flavivirus bearing attenuated japanese encephalitis virus gene as backbone 失效减毒的日本脑炎病毒基因的减毒嵌合黄病毒为骨架公开(公告)号：US08492532B2
公开(公告)日：2013-07-23
申请号：US12292518
申请日：2008-11-20
申请人： Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
发明人： Kouichi Morita , Takeshi Nabeshima , Shinichi Miyake , Toshiyuki Onishi , Isao Fuke , Toyokazu Ishikawa , Hideo Goda , Masahide Ishibashi , Michiaki Takahashi
CPC分类号： A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2770/24134 , C12N2770/24161 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： A nucleic acid molecule containing nucleotide sequences that encode the capsid protein, pre-membrane protein and non-structural protein of Japanese encephalitis virus, and a nucleotide sequence that encodes the envelop protein of a second flavivirus, wherein the nucleotide sequence(s) that encode(s) the pre-membrane protein and/or non-structural protein of Japanese encephalitis virus contain(s) nucleotide mutations that produce one or more amino acid mutations that attenuate the virus.
摘要翻译： 含有编码日本脑炎病毒的衣壳蛋白，膜前蛋白质和非结构蛋白质的核苷酸序列的核酸分子和编码第二黄病毒的包膜蛋白的核苷酸序列，其中编码的核苷酸序列 日本脑炎病毒的膜前蛋白质和/或非结构蛋白质含有产生一种或多种减弱病毒的氨基酸突变的核苷酸突变。
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5.发明申请PROMOTER FOR INTRODUCING A GENE INTO A LYMPHOCYTE OR BLOOD CELL AND APPLICATION THEREOF 有权将基因引入淋巴细胞或血液细胞的推广者及其应用公开(公告)号：US20090214579A1
公开(公告)日：2009-08-27
申请号：US12195665
申请日：2008-08-21
申请人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
发明人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
CPC分类号： C12N15/85 , A61K2039/53 , C12N2710/16522 , C12N2830/008 , C12N2830/60
摘要： It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
摘要翻译： 旨在提供用于在免疫活性细胞和/或血细胞例如淋巴细胞中选择性和强烈诱导表达的启动子。 在本发明中，通过发现HHV6MIE启动子，HHV7MIE启动子和HHV7U95启动子在免疫活性细胞和/或血细胞如T淋巴细胞中意外诱导特异性表达，实现了目的。 通过利用启动子，可以实现DNA疫苗的选择性递送等。
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6.发明申请Promoter for Introducing a Gene into a Lymphocyte or Blood Cell and Application Thereof 有权将基因引入淋巴细胞或血细胞的启动子及其应用公开(公告)号：US20100005536A1
公开(公告)日：2010-01-07
申请号：US11991637
申请日：2006-09-05
申请人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
发明人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
IPC分类号： A01K67/027 , C12N15/11 , C12N5/00 , C12N5/06 , A61K31/711 , A61K39/00 , A61K31/7105 , C12P21/00
CPC分类号： C12N15/85 , A61K2039/53 , C12N2710/16522 , C12N2830/008 , C12N2830/60
摘要： It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
摘要翻译： 旨在提供用于在免疫活性细胞和/或血细胞例如淋巴细胞中选择性和强烈诱导表达的启动子。 在本发明中，通过发现HHV6MIE启动子，HHV7MIE启动子和HHV7U95启动子在免疫活性细胞和/或血细胞如T淋巴细胞中意外诱导特异性表达，实现了目的。 通过利用启动子，可以实现DNA疫苗的选择性递送等。
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公开(公告)号：US20090208516A1
公开(公告)日：2009-08-20
申请号：US12195647
申请日：2008-08-21
申请人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
发明人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
CPC分类号： C12N15/85 , A61K2039/53 , C12N2710/16522 , C12N2830/008 , C12N2830/60
摘要： It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
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公开(公告)号：US08013139B2
公开(公告)日：2011-09-06
申请号：US12195647
申请日：2008-08-21
申请人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
发明人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
CPC分类号： C12N15/85 , A61K2039/53 , C12N2710/16522 , C12N2830/008 , C12N2830/60
摘要： It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
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9.发明授权Promoter for introducing a gene into a lymphocyte or blood cell and application thereof 有权将基因导入淋巴细胞或血细胞的启动子及其应用公开(公告)号：US08013140B2
公开(公告)日：2011-09-06
申请号：US12195665
申请日：2008-08-21
申请人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
发明人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
CPC分类号： C12N15/85 , A61K2039/53 , C12N2710/16522 , C12N2830/008 , C12N2830/60
摘要： It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
摘要翻译： 旨在提供用于在免疫活性细胞和/或血细胞例如淋巴细胞中选择性和强烈诱导表达的启动子。 在本发明中，通过发现HHV6MIE启动子，HHV7MIE启动子和HHV7U95启动子在免疫活性细胞和/或血细胞如T淋巴细胞中意外诱导特异性表达，实现了目的。 通过利用启动子，可以实现DNA疫苗的选择性递送等。
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公开(公告)号：US08008467B2
公开(公告)日：2011-08-30
申请号：US11991637
申请日：2006-09-05
申请人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
发明人： Masaya Takemoto , Yasuko Mori , Koichi Yamanishi , Isao Fuke , Yasuyuki Gomi , Michiaki Takahashi
CPC分类号： C12N15/85 , A61K2039/53 , C12N2710/16522 , C12N2830/008 , C12N2830/60
摘要： It is intended to provide a promoter for inducing expression selectively and strongly in an immunocompetent cell and/or a blood cell such as a lymphocyte. In the invention, the object was achieved by finding that HHV6 MIE promoter, HHV7 MIE promoter and HHV7 U95 promoter unexpectedly induce a specific expression in an immunocompetent cell and/or a blood cell such as a T lymphocyte. By utilizing the promoters, a selective delivery of a DNA vaccine or the like can be realized.
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