公开(公告)号：US20140206575A1

公开(公告)日：2014-07-24

申请号：US14242906

申请日：2014-04-02

Applicant: MorphoSys AG

Inventor： Stefanie Urlinger ,  Thomas Tiller ,  Ingrid Schuster ,  Yvonne Stark

IPC: C07K16/00 ,  C12N15/10

CPC classification number: G01N33/6854 ,  C07K16/005 ,  C07K2317/55 ,  C07K2317/567 ,  C12N15/1037 ,  C40B40/08

Abstract: The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select against any antigen using, for example, phage display.

Abstract translation: 本公开使得可变重链和可变轻链对的收集部分包含预先选择用于与显影性相关的功能性质的种系蛋白序列，其中所述集合可以用于使用例如， 噬菌体展示。

公开(公告)号：US09541559B2

公开(公告)日：2017-01-10

申请号：US14242906

申请日：2014-04-02

Applicant: MorphoSys AG

Inventor： Stefanie Urlinger ,  Thomas Tiller ,  Ingrid Schuster ,  Yvonne Stark

IPC: C40B40/08 ,  G01N33/68 ,  C07K16/00 ,  C12N15/10

CPC classification number: G01N33/6854 ,  C07K16/005 ,  C07K2317/55 ,  C07K2317/567 ,  C12N15/1037 ,  C40B40/08

Abstract: The present disclosure enables collections of variable heavy chain and variable light chain pairs comprising, in part, germline protein sequences that are pre-selected for functional properties relevant to developability, wherein the collections may be used to select against any antigen using, for example, phage display.

Abstract translation: 本公开使得可变重链和可变轻链对的收集部分包含预先选择用于与显影性相关的功能性质的种系蛋白序列，其中所述集合可以用于使用例如， 噬菌体展示。