公开(公告)号：US06909919B2

公开(公告)日：2005-06-21

申请号：US10236310

申请日：2002-09-06

申请人： Mudit Jain ,  Qingsheng Zhu ,  Rodney W. Salo

发明人： Mudit Jain ,  Qingsheng Zhu ,  Rodney W. Salo

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： For chronic monitoring of the effects of pacing and/or drug therapy in treating CHF, a strain gauge element is disposed at the distal end of a cardiac lead and is effective to produce a signal relating to the amount of flexure being induced into the lead by the beating action of the heart.

摘要翻译： 为了慢性监测起搏和/或药物治疗在治疗CHF中的作用，应变计元件设置在心脏引线的远端，并且有效地产生与通过引导引入的弯曲量相关的信号 心跳的动作。

公开(公告)号：US20080208274A1

公开(公告)日：2008-08-28

申请号：US12150296

申请日：2008-04-25

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

摘要翻译： 公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

公开(公告)号：US07366567B2

公开(公告)日：2008-04-29

申请号：US11088231

申请日：2005-03-23

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/365

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

公开(公告)号：US20120041506A1

公开(公告)日：2012-02-16

申请号：US13281096

申请日：2011-10-25

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/368 ,  A61N1/365

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

摘要翻译： 公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

公开(公告)号：US08050761B2

公开(公告)日：2011-11-01

申请号：US12150296

申请日：2008-04-25

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/365 ,  A61N1/08

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

摘要翻译： 公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

公开(公告)号：US06829506B2

公开(公告)日：2004-12-07

申请号：US09915088

申请日：2001-07-25

申请人： Joseph M. Pastore ,  Qingsheng Zhu ,  Rodney W. Salo

发明人： Joseph M. Pastore ,  Qingsheng Zhu ,  Rodney W. Salo

IPC分类号： A61N1362

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A method and apparatus for linear stimulation of the heart to resynchronize contraction for improved hemodynamic benefit. Linear stimulation may be accomplished using a linear source, which may comprise an elongated electrode or plurality of electrodes arranged so as to linearly stimulate the heart. A linear source may be coupled to the left ventricle, and one or more additional electrodes may be positioned so as to stimulate a separate region of the left ventricle or one or more additional chambers of the heart as well. Application of an electrical stimulus by the linear source may function to stimulate a larger region of the heart, thereby enhancing the resynchronization effect as well as providing other hemodynamic benefits.

摘要翻译： 用于线性刺激心脏以重新同步收缩以改善血液动力学益处的方法和装置。 线性刺激可以使用线性源实现，线性源可以包括细长电极或多个电极，其布置成线性刺激心脏。 线性源可以耦合到左心室，并且可以定位一个或多个附加电极，以便也刺激心脏的左心室或一个或多个另外的腔室的单独区域。 通过线性源的电刺激的应用可以起到刺激心脏的较大区域的作用，从而增强再同步效应以及提供其它血液动力学优点。

公开(公告)号：US08406878B2

公开(公告)日：2013-03-26

申请号：US13281096

申请日：2011-10-25

申请人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

发明人： Qingsheng Zhu ,  Joseph M. Pastore ,  Rodney W. Salo

IPC分类号： A61N1/362

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： A method for treating patients after a myocardial infarction which includes pacing therapy is disclosed. A cardiac rhythm management device is configured to deliver pre-excitation pacing to one or more sites in proximity to an infarcted region of the ventricular myocardium. Such pacing acts to minimize the remodeling process to which the heart is especially vulnerable immediately after a myocardial infarction.

摘要翻译： 公开了一种治疗包括起搏治疗在内的心肌梗死后患者的方法。 心律管理装置被配置为将预激励起搏递送到心室心肌梗塞区域附近的一个或多个部位。 这种起搏用于最小化在心肌梗死后心脏特别脆弱的重塑过程。

公开(公告)号：US07039462B2

公开(公告)日：2006-05-02

申请号：US10172825

申请日：2002-06-14

申请人： Joseph M. Pastore ,  Rodney W. Salo ,  Quan Ni ,  Qingsheng Zhu ,  Jiang Ding

发明人： Joseph M. Pastore ,  Rodney W. Salo ,  Quan Ni ,  Qingsheng Zhu ,  Jiang Ding

IPC分类号： A61N1/39 ,  A61B5/05

CPC分类号： A61N1/3925 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/36542

摘要： A cardiac rhythm management device is configured to detect mechanical oscillations in cardiac rhythm. Upon detection of such oscillations, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

公开(公告)号：US07225024B2

公开(公告)日：2007-05-29

申请号：US10677144

申请日：2003-09-30

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/365 ,  A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： A cardiac management implantable device that has an intravascular device body, and one or more chemical sensors coupled with the intravascular device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种具有血管内装置体的心脏管理可植入装置，以及与血管内装置本体结合的一个或多个化学传感器。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。

公开(公告)号：US08131364B2

公开(公告)日：2012-03-06

申请号：US12984161

申请日：2011-01-04

申请人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

发明人： Qingsheng Zhu ,  Ronald W. Heil, Jr. ,  Mudit Jain

IPC分类号： A61N1/00

CPC分类号： A61B5/14546 ,  A61B5/14532 ,  A61N1/0568

摘要： An apparatus includes an implantable device, such as a chronically implantable device that has a device body. One or more chemical sensors are coupled with the device body. A drug eluting substance is disposed at a location including at least one of on, directly adjacent, or near the one or more chemical sensors, where the drug eluting substance prevents fibrotic growth on the one or more chemical sensors.

摘要翻译： 一种装置包括可植入装置，例如具有装置主体的长期可植入装置。 一个或多个化学传感器与装置本体结合。 药物洗脱物质被布置在包括一个或多个化学传感器中的至少一个，直接相邻或接近的位置，其中药物洗脱物质防止在一个或多个化学传感器上的纤维化生长。