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1.发明申请Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives 有权制备3-氨基四氢呋喃，其盐和衍生物的手性和外消旋形式的方法公开(公告)号：US20080255377A1
公开(公告)日：2008-10-16
申请号：US11733772
申请日：2007-04-11
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
IPC分类号： C07D307/02
CPC分类号： C07D307/22
摘要： A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.
摘要翻译： 描述了（S）-3-氨基 - 四氢呋喃和（R）-3-氨基 - 四氢呋喃的合成的新方法。 该方法适用于取代的手性3-氨基四氢呋喃衍生物。
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2.发明授权Processes for the manufacture of chiral and racemic forms of 3-aminotetrahydrofurans, their salts and derivatives 有权用于制造手性和外消旋形式的3-氨基四氢呋喃，其盐和衍生物的方法公开(公告)号：US07514573B2
公开(公告)日：2009-04-07
申请号：US11733772
申请日：2007-04-11
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
IPC分类号： C07D307/22
CPC分类号： C07D307/22
摘要： A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.
摘要翻译： 描述了（S）-3-氨基 - 四氢呋喃和（R）-3-氨基 - 四氢呋喃的合成的新方法。 该方法适用于取代的手性3-氨基四氢呋喃衍生物。
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公开(公告)号：US10421734B1
公开(公告)日：2019-09-24
申请号：US16185018
申请日：2018-11-09
IPC分类号： C07D307/22 , C07C271/16 , C07C233/69 , C07C233/83
摘要： Disclosed is simple, novel, scalable and environment friendly process for the preparation of enantiopure 3-amino tetrahydrofuran and its salts.
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公开(公告)号：US10407401B1
公开(公告)日：2019-09-10
申请号：US16055054
申请日：2018-08-04
IPC分类号： C07D311/30
摘要： Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.
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5.发明授权Synthesis of 4-aryl 4-acyl piperidine, its salts and analogs using indium metal 有权使用铟金属合成4-芳基-4-酰基哌啶，其盐和类似物公开(公告)号：US08853407B1
公开(公告)日：2014-10-07
申请号：US14099913
申请日：2013-12-07
IPC分类号： C07D211/82 , C07D211/32
CPC分类号： C07D211/32 , C07D211/82
摘要： A novel process for the synthesis of 4-aryl 4-acyl piperidine derivatives using indium metal is described. Specifically, a novel process for the synthesis of 4-acetyl 4-phenyl piperidine and its salts using indium metal is described.
摘要翻译： 描述了使用铟金属合成4-芳基4-酰基哌啶衍生物的新方法。 具体地说，描述了使用铟金属合成4-乙酰基4-苯基哌啶及其盐的新方法。
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6.发明授权公开(公告)号：US08003614B2
公开(公告)日：2011-08-23
申请号：US11749184
申请日：2007-05-16
IPC分类号： A61K38/05
CPC分类号： C07K5/06191 , A61K8/64 , A61K38/00 , A61Q7/00
摘要： Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent/reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.
摘要翻译： 公开了通过L-硒代甲硫氨酸或Se-甲基-L-硒代半胱氨酸与L-谷氨酸的适当连接的异构肽的新型合成方法。 该新颖的合成方法产生L-硒代甲硫氨酸或Se-甲基-L-硒代半胱氨酸的异构肽，其显示出（i）增强的水溶性; （ii）提高水中溶解度; （iii）提高生物利用度; （iv）优异的血管内皮生长因子促进活性; （v）优异的抗5α-还原酶活性; （vi）防止/减少“头发下降”并促进“头发生长”的能力，从而保持“头发护理”的完美的体内平衡。 还公开了包含通过L-硒代甲硫氨酸或Se-甲基-L-硒代半胱氨酸与L-谷氨酸的适当连接获得的异构体肽的药妆组合物和药物组合物。 还公开了具有几种其它氨基酸的其它二肽及其用途。
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公开(公告)号：US20210106543A1
公开(公告)日：2021-04-15
申请号：US17071637
申请日：2020-10-15
摘要： The present invention discloses a composition comprising 70%-80% w/w tetrahydrocurcuminoids, 10%-20% w/w hexahydrocurcuminoids and 5%-10% w/w octahydrocurcuminoids and its therapeutic application. More specifically, the present invention discloses the use of a composition comprising 70%-80% w/w tetrahydrocurcuminoids, 10%-20% w/w hexahydrocurcuminoids and 5%-10% w/w octahydrocurcuminoids in the therapeutic management of metabolic syndrome in mammals.
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8.发明授权公开(公告)号：US10588844B2
公开(公告)日：2020-03-17
申请号：US16135240
申请日：2018-09-19
摘要： The present disclosure provides oleanoyl tripeptide to prevent skin aging. More specifically the invention discloses the anti-collagenase, anti-elastase, enhancement of TGF-β secretion in fibroblasts, UV protection, oxidative stress protection, and other properties of the oleanoyl-KVK tripeptide which aids in preventing skin aging.
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9.发明申请公开(公告)号：US20190083378A1
公开(公告)日：2019-03-21
申请号：US16135240
申请日：2018-09-19
CPC分类号： A61K8/645 , A61K2800/56 , A61K2800/57 , A61Q19/08
摘要： The present disclosure provides oleanoyl tripeptide to prevent skin aging. More specifically the invention discloses the anti-collagenase, anti-elastase, enhancement of TGF-β secretion in fibroblasts, UV protection, oxidative stress protection, and other properties of the oleanoyl-KVK tripeptide which aids in preventing skin aging.
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10.发明授权公开(公告)号：US08193156B1
公开(公告)日：2012-06-05
申请号：US13175016
申请日：2011-07-01
IPC分类号： A61K38/05
CPC分类号： C07K5/06191 , A61K8/64 , A61K38/00 , A61Q7/00
摘要： Disclosed is a novel synthetic method for isomeric peptides through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid. The novel synthetic method produces isomeric peptides of L-selenomethionine or Se-Methyl-L-selenocysteine that exhibit (i) enhanced water solubility; (ii) enhanced rate of dissolution in water; (iii) enhanced bioavailability; (iv) excellent vascular endothelial growth factor promoting activity; (v) excellent anti-5-alpha-reductase activity; (vi) capabilities to prevent/reduce “hair fall” and promote “hair growth”, thereby maintaining a perfect homeostasis for “hair care”. Cosmeceutical and pharmaceutical compositions comprising the isomeric peptides obtained through an appropriate linkage of L-selenomethionine or Se-Methyl-L-selenocysteine with L-glutamic acid are also disclosed. Other dipeptides with several other amino acids and uses thereof are also disclosed.
摘要翻译： 公开了通过L-硒代甲硫氨酸或Se-甲基-L-硒代半胱氨酸与L-谷氨酸的适当连接的异构肽的新型合成方法。 该新颖的合成方法产生L-硒代甲硫氨酸或Se-甲基-L-硒代半胱氨酸的异构肽，其显示出（i）增强的水溶性; （ii）提高水中溶解度; （iii）提高生物利用度; （iv）优异的血管内皮生长因子促进活性; （v）优异的抗5α-还原酶活性; （vi）防止/减少“头发下降”并促进“头发生长”的能力，从而保持“头发护理”的完美的体内平衡。 还公开了包含通过L-硒代甲硫氨酸或Se-甲基-L-硒代半胱氨酸与L-谷氨酸的适当连接获得的异构体肽的药妆组合物和药物组合物。 还公开了具有几种其它氨基酸的其它二肽及其用途。
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