公开(公告)号：US07521580B1

公开(公告)日：2009-04-21

申请号：US12032955

申请日：2008-02-18

Applicant: Muhammed Majeed ,  Rajinder Kumar Bammi ,  Natarajan Sankaran ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Susmitha Anand ,  Geetha Kanhangad-Gangadharan

Inventor： Muhammed Majeed ,  Rajinder Kumar Bammi ,  Natarajan Sankaran ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Susmitha Anand ,  Geetha Kanhangad-Gangadharan

IPC: C07C49/203 ,  C07C49/215 ,  A61K31/12

CPC classification number: C07C49/248 ,  A61K31/12 ,  C07C45/74

Abstract: Disclosed are novel, synthetic analogues of (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione and the therapeutic applications for cystic fibrosis thereof in correcting altered CFTR trafficking and the associated impaired chloride (Cl−) ion transport. Introduction of branched-alkyl groups ortho to the phenolic groups gave rise to clinical compounds with vastly improved trafficking of delF508CFTR and with no cytotoxicity.

Abstract translation: 公开了（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮的新型合成类似物，以及用于其改变的囊性纤维化的治疗应用 CFTR贩运和相关的氯化物（Cl - ）离子迁移。 引入酚基团邻位的支链烷基产生临床化合物，其具有大大改善的delF508CFTR的运输并且没有细胞毒性。

公开(公告)号：US07014874B1

公开(公告)日：2006-03-21

申请号：US10605578

申请日：2003-10-09

Applicant: Muhammed Majeed ,  Rajinder Kumar Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Nagabhushanam Kalyanam

Inventor： Muhammed Majeed ,  Rajinder Kumar Bammi ,  Vladimir Badmaev ,  Subbalakshmi Prakash ,  Nagabhushanam Kalyanam

IPC: A61K35/78

CPC classification number: A61K36/8962

Abstract: The invention discloses a method to prepare concentrates from Allium sativum Linn. (Garlic) bulbs naturally enriched with an unique composition of organic selenium compounds and the use of such concentrates in nutritional supplement compositions for human and animal use. The resulting compositions provide a safe and efficacious means of providing supplemental amounts of the essential trace mineral nutrient selenium for diverse health benefits.

Abstract translation: 本发明公开了一种从葱属中制备浓缩物的方法。 （大蒜）灯泡天然富含有机硒化合物的独特组合物，以及这些浓缩物用于人类和动物使用的营养补充剂组合物中的用途。 所得组合物提供了一种安全有效的手段，提供补充量的必需痕量矿物营养硒，以获得不同的健康益处。

公开(公告)号：US08383594B2

公开(公告)日：2013-02-26

申请号：US11835165

申请日：2007-08-07

Applicant: Muhammed Majeed ,  Renukeshwar H Chandramouli ,  Kalyanam Nagabhushanam ,  Rattan Sood ,  Subbalakshmi Prakash ,  Susmitha Anand

Inventor： Muhammed Majeed ,  Renukeshwar H Chandramouli ,  Kalyanam Nagabhushanam ,  Rattan Sood ,  Subbalakshmi Prakash ,  Susmitha Anand

IPC: A61K38/08 ,  A61K8/64

CPC classification number: A61Q19/08 ,  A61K8/64 ,  A61Q19/00

Abstract: The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.

Abstract translation: 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。

公开(公告)号：US20100034762A1

公开(公告)日：2010-02-11

申请号：US12208024

申请日：2008-09-10

Applicant: Muhammed Majeed ,  Atul Namdevrao Jadhav ,  Jyotish Shanker Srivastava ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Beena Bhat

Inventor： Muhammed Majeed ,  Atul Namdevrao Jadhav ,  Jyotish Shanker Srivastava ,  Subbalakshmi Prakash ,  Kalyanam Nagabhushanam ,  Beena Bhat

IPC: A61Q17/04 ,  C07H17/02 ,  C07C69/76 ,  C07C63/04 ,  C07D311/78 ,  A61P35/00 ,  A61K31/7088 ,  A61K31/235 ,  A61K31/19 ,  A61K31/35

CPC classification number: A61K8/97 ,  A61K8/375 ,  A61K8/60 ,  A61K2800/522 ,  A61Q17/04 ,  A61Q19/02 ,  C07C67/58 ,  C07D307/33 ,  C07D493/06 ,  C07H13/08 ,  Y02P20/544 ,  C07C69/84

Abstract: Improved methods to prepare aqueous extracts of gallic acid esters including 1-O-galloyl-β-D-glucose (β-glucogallin) and other mucic acid gallates from the fruits of Emblica officinalis, wherein enrichment of gallic acid esters is achieved by Supercritical Fluid Extraction (SCFE) procedure, are disclosed. The use of such standardized extracts of gallic acid esters (greater than 40% w/w of gallic acid esters) in the manufacture of medicaments with diverse health benefits, is also disclosed.

Abstract translation: 改进的方法，用于制备没食子酸酯的含水提取物，其中包括从Emblica officinalis的果实中含有1-O-葡萄糖基-β-D-葡萄糖（β-葡萄糖苷）和其他没有酸的粘酸盐，其中富马酸酯的富集通过超临界流体 提取（SCFE）程序。 还公开了在制造具有多种健康益处的药物中使用没食子酸酯（大于40％w / w的没食子酸酯）的标准提取物。

公开(公告)号：US20070231345A1

公开(公告)日：2007-10-04

申请号：US11754646

申请日：2007-05-29

Applicant: Muhammed Majeed ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Subbalakshmi Prakash

IPC: A61K36/324 ,  A61K31/56

CPC classification number: A61K31/28 ,  A61K31/56 ,  A61K33/04 ,  A61K36/324 ,  A61K45/06 ,  A61K2300/00

Abstract: The current invention discloses a medicament and its use in a method for therapeutically managing hyperproliferative diseases of the skin in particular, psoriasis of the skin, scalp and nails. The medicament includes a dual inhibitor of 5-lipoxygenase and human leukocyte elastase singly or in combination with a bioavailable organic selenium nutritional supplement. In particular, the medicament includes (a) an oral formulation of acetyl-11-keto-beta-boswellic acid in combination with a bioavailable organic selenium supplement dispersed in a pharmaceutical carrier; and (b) a topical formulation of acetyl-11-keto-beta-boswellic acid alone dispersed in a pharmaceutical carrier. The said medicament is shown to be effective for the therapeutic management of clinical psoriasis based on its ability to (i) provide relief of clinical symptoms and (ii) the ability to clear psoriatic lesions as evaluated in 3 months, open, prospective, multi-center, phase III Clinical study.

Abstract translation: 本发明公开了一种药物及其用于治疗性地治疗皮肤过度增生性疾病，特别是皮肤，头皮和指甲的牛皮癣的方法中的用途。 药物包括单独的或与生物可利用的有机硒营养补充剂组合的5-脂氧合酶和人白细胞弹性蛋白酶的双重抑制剂。 特别地，药物包括（a）乙酰基-11-酮基-β-乳糖酸与分散在药物载体中的生物可利用的有机硒补充剂的口服制剂; 和（b）分散在药物载体中的乙酰基-11-酮-β-乳糖酸的局部制剂。 所述药物被证明对于治疗性治疗临床银屑病是有效的，其基于其能力（i）缓解临床症状，以及（ii）如3个月，开放，预期，多发， 中心，III期临床研究。

公开(公告)号：US07253324B1

公开(公告)日：2007-08-07

申请号：US11626225

申请日：2007-01-23

Applicant: Muhammed Majeed ,  Samuel Manoharan Thomas ,  Kalyanam Nagabhushanam ,  Sivaprakash Kurumanghat Balakrishnan ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Samuel Manoharan Thomas ,  Kalyanam Nagabhushanam ,  Sivaprakash Kurumanghat Balakrishnan ,  Subbalakshmi Prakash

IPC: C07C37/00

CPC classification number: C07C39/27 ,  C07C37/055 ,  C07C39/14 ,  C07C39/19 ,  C07C39/21 ,  C07C41/26 ,  C07C43/23 ,  C07C51/377 ,  C07C253/30 ,  C07C65/21 ,  C07C255/53 ,  C07C39/24

Abstract: Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.

Abstract translation: 通过用氯化铝/ N，N-二甲基苯胺络合物处理，烷氧基芳族化合物方便地脱苄基化成相应的酚类化合物。 芳族聚O-脱甲基是本发明的独特特征。 该方法适用于多酚如白藜芦醇，氧化藜芦醇，Gnetol的制造。

公开(公告)号：US20050123559A1

公开(公告)日：2005-06-09

申请号：US10710778

申请日：2004-08-02

Applicant: Muhammed Majeed ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Subbalakshmi Prakash

IPC: A61K31/198 ,  A61K31/704 ,  A61K33/04 ,  A61K36/324

CPC classification number: A61K31/704 ,  A61K31/198 ,  A61K36/324 ,  A61K2300/00

Abstract: The invention describes compositions and methods for the management of hyperproliferative skin conditions such as psoriasis. The preferential composition contains a natural leukotriene inhibitor selected from Boswellia serrata gum resin, its extractives, isolates or derivatives in combination with a bioavailable organic selenium nutritional supplement. These compositions are administered orally and topically to the individual human or animal in need of treatment at optimal levels to manifest the desired benefits, with no untoward side effects

Abstract translation: 本发明描述了用于治疗过度增生性皮肤病症如牛皮癣的组合物和方法。 优选组合物含有天然白三烯抑制剂，其选自芥子油树胶，其提取物，分离物或衍生物与生物可利用的有机硒营养补充剂组合。 将这些组合物口服和局部给予需要以最佳水平治疗的个体人或动物，以表现出期望的益处，而没有不利的副作用

公开(公告)号：US06436991B1

公开(公告)日：2002-08-20

申请号：US09860778

申请日：2001-05-21

Applicant: Muhammed Majeed ,  Vladimir Badmaev ,  Rajinder Kumar Bammi ,  Subbalakshmi Prakash ,  Sankaran Natarajan

Inventor： Muhammed Majeed ,  Vladimir Badmaev ,  Rajinder Kumar Bammi ,  Subbalakshmi Prakash ,  Sankaran Natarajan

IPC: A01N3710

CPC classification number: C07C69/734

Abstract: Ferulate compounds derived from extracts from the plant Commiphora wightii are used in compositions and methods for prevention and treatment of abnormal cell growth and proliferation in inflammation, neoplasia and cardiovascular disease.

Abstract translation: 来自植物蓟马提取物的化合物的化合物用于预防和治疗炎症，瘤形成和心血管疾病中异常细胞生长和增殖的组合物和方法。

公开(公告)号：US20110091398A1

公开(公告)日：2011-04-21

申请号：US12979667

申请日：2010-12-28

Applicant: Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Renukeshwar H. Chandramouli ,  Rattan Sood ,  Subbalakshmi Prakash ,  Susmitha Anand Tathapudi

Inventor： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Renukeshwar H. Chandramouli ,  Rattan Sood ,  Subbalakshmi Prakash ,  Susmitha Anand Tathapudi

IPC: A61K8/64 ,  C07K7/06 ,  A61K8/97 ,  A61Q19/08 ,  A61Q17/04 ,  A61Q19/02

CPC classification number: A61K8/64 ,  A61K2800/57 ,  A61K2800/78 ,  A61Q19/00 ,  A61Q19/007 ,  A61Q19/04 ,  A61Q19/08 ,  C07K7/06

Abstract: The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.

Abstract translation: 本发明涉及与齐墩果酸连接的含有SEQ ID No.1的肽的组合物和治疗皮肤老化的方法。 该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。

公开(公告)号：US20110054018A1

公开(公告)日：2011-03-03

申请号：US12872675

申请日：2010-08-31

Applicant: Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

Inventor： Muhammed Majeed ,  Kalyanam Nagabhushanam ,  Samuel Manoharan Thomas ,  Subbalakshmi Prakash

IPC: A61K31/341 ,  C07D307/58 ,  C07D407/10 ,  A61P9/10 ,  A61P25/16 ,  A61P35/00

CPC classification number: C07D307/58 ,  A23L31/00 ,  A23L33/10 ,  A61K31/341

Abstract: Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed.

Abstract translation: 本发明公开了5-甲基-3（2H） - 呋喃酮化合物和苯丙素类聚酮化合物与艾吐子酮相关的衍生物的最佳组合物，其在健康和疾病中发挥生物反应修饰及其制备方法。 还公开了使用这些组合物治疗由诱导型一氧化氮合酶（iNOS）过表达引起的退行性病症的方法。