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1.发明申请Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives 有权制备3-氨基四氢呋喃，其盐和衍生物的手性和外消旋形式的方法公开(公告)号：US20080255377A1
公开(公告)日：2008-10-16
申请号：US11733772
申请日：2007-04-11
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
IPC分类号： C07D307/02
CPC分类号： C07D307/22
摘要： A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.
摘要翻译： 描述了（S）-3-氨基 - 四氢呋喃和（R）-3-氨基 - 四氢呋喃的合成的新方法。 该方法适用于取代的手性3-氨基四氢呋喃衍生物。
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2.发明授权Processes for the manufacture of chiral and racemic forms of 3-aminotetrahydrofurans, their salts and derivatives 有权用于制造手性和外消旋形式的3-氨基四氢呋喃，其盐和衍生物的方法公开(公告)号：US07514573B2
公开(公告)日：2009-04-07
申请号：US11733772
申请日：2007-04-11
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Sivaprskash Kurumanghat Balakrishnan , Savita Ganjihal , Rajendran Ramanujam , Rattan Sood , Subbalakshmi Prakash
IPC分类号： C07D307/22
CPC分类号： C07D307/22
摘要： A novel process for the synthesis of (S)-3-Amino-tetrahydrofuran and (R)-3-Amino-tetrahydrofuran is described. The process is applicable for substituted chiral-3-aminotetrahydrofuran derivatives.
摘要翻译： 描述了（S）-3-氨基 - 四氢呋喃和（R）-3-氨基 - 四氢呋喃的合成的新方法。 该方法适用于取代的手性3-氨基四氢呋喃衍生物。
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公开(公告)号：US10421734B1
公开(公告)日：2019-09-24
申请号：US16185018
申请日：2018-11-09
IPC分类号： C07D307/22 , C07C271/16 , C07C233/69 , C07C233/83
摘要： Disclosed is simple, novel, scalable and environment friendly process for the preparation of enantiopure 3-amino tetrahydrofuran and its salts.
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4.发明申请OLEANOYL PEPTIDE COMPOSITION AND A METHOD OF TREATING SKIN AGING 有权OLEANOYL PEPTIDE COMPOSITION和一种治疗皮肤老化的方法公开(公告)号：US20110091398A1
公开(公告)日：2011-04-21
申请号：US12979667
申请日：2010-12-28
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
CPC分类号： A61K8/64 , A61K2800/57 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/04 , A61Q19/08 , C07K7/06
摘要： The present invention relates to a composition containing peptide of SEQ ID No. 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
摘要翻译： 本发明涉及与齐墩果酸连接的含有SEQ ID No.1的肽的组合物和治疗皮肤老化的方法。 该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。
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5.发明授权Peptides modified with triterpenoids and small organic molecules: synthesis and use in cosmeceuticals 有权用三萜类化合物和小有机分子修饰的肽：合成和用于药妆品公开(公告)号：US08383594B2
公开(公告)日：2013-02-26
申请号：US11835165
申请日：2007-08-07
申请人： Muhammed Majeed , Renukeshwar H Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
发明人： Muhammed Majeed , Renukeshwar H Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
摘要翻译： 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。
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公开(公告)号：US08987212B2
公开(公告)日：2015-03-24
申请号：US12979667
申请日：2010-12-28
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand Tathapudi
CPC分类号： A61K8/64 , A61K2800/57 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/04 , A61Q19/08 , C07K7/06
摘要： The present invention relates to a composition containing peptide of SEQ ID NO: 1 linked to oleanolic acid and a method of treating skin aging. The composition effectively reduces signs of ageing due to oxidation, collagen insufficiency and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin, fine expression lines, reduced skin thickness, hyperpigmentation, under eye dark circles, and premature ageing.
摘要翻译： 本发明涉及与齐墩果酸连接的含有SEQ ID NO：1的肽的组合物和治疗皮肤老化的方法。 该组合物有效地减少由于氧化，胶原蛋白不足和丝氨酸蛋白酶如弹性蛋白酶和胶原酶的过度活动导致皮肤皱纹，细纹，减少皮肤厚度，色素沉着过度，眼睛黑眼圈和过早老化等现象。
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7.发明申请Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceutical 审中-公开用三萜类化合物和小有机分子修饰的肽：合成和用于药妆公开(公告)号：US20140206842A1
公开(公告)日：2014-07-24
申请号：US13746633
申请日：2013-01-22
申请人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
发明人： Muhammed Majeed , Kalyanam Nagabhushanam , Renukeshwar H. Chandramouli , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
IPC分类号： C07K1/107
CPC分类号： C07K1/1077 , C07K7/06
摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the Synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
摘要翻译： 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上出现细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。
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8.发明申请Peptides Modified with Triterpenoids and Small Organic Molecules: Synthesis and use in Cosmeceuticals 有权用三萜类化合物和小有机分子修饰的肽：在化妆品中的合成和应用公开(公告)号：US20100034758A1
公开(公告)日：2010-02-11
申请号：US11835165
申请日：2007-08-07
申请人： Muhammed Majeed , Renukeshwar H. Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
发明人： Muhammed Majeed , Renukeshwar H. Chandramouli , Kalyanam Nagabhushanam , Rattan Sood , Subbalakshmi Prakash , Susmitha Anand
摘要： The present invention relates to the Synthesis of Triterpenoid peptides and mechanism of action for Anti ageing and skin care. The present invention is directed towards anti-aging skin care compositions comprising peptides which are made by linking herbal actives to a pentapeptide for enhanced anti ageing activity by regenerating the dermal matrix. In detail, the present invention relates to the synthesis of Triterpenoid peptides, providing an enhanced and synergistic activity for reducing the consequences of ageing such as appearance of fine expression lines and wrinkles on the skin by cosmetic modes of application. The Triterpenoid peptides of the present invention with its novel dual action mode can be used for skin ageing & collagen insufficiency. Its Triterpenoid group acts by preventing oxidation and excess activity of serine proteases like elastase and collagenase that result in wrinkling of skin. With added peptides which boost the collagen and other matrix protein, Triterpenoid peptides provide a complete protection against pre mature ageing and functions as a best anti ageing ingredient.
摘要翻译： 本发明涉及三萜类肽的合成及抗衰老和皮肤护理的作用机理。 本发明涉及抗衰老皮肤护理组合物，其包含通过将草药活性物质与五肽连接而制成的肽，以通过再生真皮基质来增强抗衰老活性。 详细地说，本发明涉及三萜类肽的合成，提供增强的和协同的活性，以减少老化的后果，例如通过美容方式在皮肤上表现出细小的表达线和皱纹。 具有其新颖双作用模式的本发明的三萜类肽可用于皮肤老化和胶原蛋白不足。 其三萜类化合物通过防止丝氨酸蛋白酶如弹性蛋白酶和胶原酶的氧化和过度活性而起作用，导致皮肤起皱。 通过添加增强胶原蛋白和其他基质蛋白质的肽，三萜类肽提供了完全保护，防止成熟老化，并作为最好的抗衰老成分。
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公开(公告)号：US10407401B1
公开(公告)日：2019-09-10
申请号：US16055054
申请日：2018-08-04
IPC分类号： C07D311/30
摘要： Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.
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10.发明授权公开(公告)号：US08394852B2
公开(公告)日：2013-03-12
申请号：US12872675
申请日：2010-08-31
IPC分类号： A61K31/34
CPC分类号： C07D307/58 , A23L31/00 , A23L33/10 , A61K31/341
摘要： Optimal compositions of derivatives of 5-methyl-3(2H)-furanone compounds and phenylpropanoid polyketides related to inotilone, that exert biological response modification in health and disease, and their method of preparation, are disclosed. Methods of treating degenerative conditions stemming from over-expression of inducible nitric oxide synthase (iNOS) using these compositions are also disclosed.
摘要翻译： 本发明公开了5-甲基-3（2H） - 呋喃酮化合物和苯丙素类聚酮化合物与艾吐子酮有关的衍生物的最佳组合物，其在健康和疾病中发挥生物反应修饰及其制备方法。 还公开了使用这些组合物治疗由诱导型一氧化氮合酶（iNOS）过表达引起的退行性病症的方法。
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